A rational tissue engineering strategy based on three-dimensional (3D) printing for extensive circumferential tracheal reconstruction

Park, Jeong Hun; Park, Ju Young; Nam, Inn‐Chul; Ahn, Minjun; Lee, Jae Yeon; Choi, Seok Hwa; Kim, Sung Won; Cho, Dong‐Woo

doi:10.1016/j.biomaterials.2018.09.031

Cited by 48 publications

(35 citation statements)

References 29 publications

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“…In contrast to physical methods, this procedure seems to be more favorable, because it minimizes the ECM damage [104][105][106]. To date, dECM from heart, lungs, kidneys, urethra, trachea, bones, cartilage, and bladders has been obtained [9,103,[105][106][107][108]. However, limited number of autologous tissues/organs and risk of infection associated with allogenous as well as xenogenous ones still represent big problems for scientists [109].…”

Section: Decellularized Extracellular Matrix (Decm)mentioning

confidence: 99%

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Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Decellularized Extracellular Matrix (Decm)mentioning

confidence: 99%

“…Nevertheless, the procedures necessary for production of cell-derived dECM are usually expensive and time-consuming [9]. Despite all these limitations, dECM derived from tissues/organs as well as cell cultures is successfully used either alone or in combination with polymers [105,106,108,109,112,113].…”

Section: Decellularized Extracellular Matrix (Decm)mentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…The silicon ring surface is covered by the layer of stratifying tracheal mucosa decellularized ECM hydrogel and human inferior turbinate mesenchymal stromal cell sheets. The preclinical study in rabbit model for 2 months showed the successful healing of the extensive tracheal defect, with complete re‐epithelization (Park, Park, Nam, et al, ).…”

Section: Progress In Tracheal Tissue Engineeringmentioning

confidence: 99%

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

Dhasmana

Singh

2020

J Tissue Eng Regen Med

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Airway system is a vital part of the living being body. Trachea is the upper respiratory portion that connects nostril and lungs and has multiple functions such as breathing and entrapment of dust/pathogen particles. Tracheal reconstruction by artificial prosthesis, stents, and grafts are performed clinically for the repairing of damaged tissue. Although these (above-mentioned) methods repair the damaged parts, they have limited applicability like small area wounds and lack of functional tissue regeneration. Tissue engineering helps to overcome the abovementioned problems by modifying the traditional used stents and grafts, not only repair but also regenerate the damaged area to functional tissue. Bioengineered tracheal replacements are biocompatible, nontoxic, porous, and having 3D biomimetic ultrastructure with good mechanical strength, which results in faster and better tissue regeneration. Till date, the bioengineered tracheal replacements studies have been going on preclinical and clinical levels. Besides that, still many researchers are working at advance level to make extracellular matrix-based acellular, 3D printed, cell-seeded grafts including living cells to overcome the demand of tissue or organ and making the ready to use tracheal reconstructs for clinical application. Thus, in this review, we summarized the tracheal tissue engineering aspects and their outcomes. K E Y W O R D S biocompatible, chondrocytes, ECM, in vivo, tissue engineering, trachea

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“…After 2 months, there was a complete regeneration of the luminal surface of the construct. Some granulation could be observed at the transplantation site but no severe complications were observed (Park et al, 2018b).…”

Section: Cellular Types Biologic Components and Hydrogelsmentioning

confidence: 91%

3D-bioprinted tracheal reconstruction: an overview

Frejo

Grande

2019

Bioelectron Med

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Congenital tracheomalacia and tracheal stenosis are commonly seen in premature infants. In adulthood, are typically related with chronic obstructive pulmonary disease, and can occur secondarily from tracheostomy, prolong intubation, trauma, infection and tumors. Both conditions are life-threatening when not managed properly. There are still some surgical limitations for certain pathologies, however tissue engineering is a promising approach to treat massive airway dysfunctions. 3D-bioprinting have contributed to current preclinical and clinical efforts in airway reconstruction. Several strategies have been used to overcome the difficulty of airway reconstruction such as scaffold materials, construct designs, cellular types, biologic components, hydrogels and animal models used in tracheal reconstruction. Nevertheless, additional long-term in vivo studies need to be performed to assess the efficacy and safety of tissue-engineered tracheal grafts in terms of mechanical properties, behavior and, the possibility of further stenosis development.

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A rational tissue engineering strategy based on three-dimensional (3D) printing for extensive circumferential tracheal reconstruction

Cited by 48 publications

References 29 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Biomedical grafts for tracheal tissue repairing and regeneration “Tracheal tissue engineering: an overview”

3D-bioprinted tracheal reconstruction: an overview

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