A rationalized and innovative perspective of nanotechnology and nanobiotechnology in chronic wound management

Kumar, Arun; Behl, Tapan; Chadha, Swati

doi:10.1016/j.jddst.2020.101930

Cited by 19 publications

(6 citation statements)

References 157 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, conductive biomaterials have demonstrated excellent performance in managing diabetic wounds though different pathways. Still, considering the variety and complexity of chronic wounds, the usage of conductive biomaterials, their combination with other reagents and specific implementation approaches need to be further explored [ 246 ].…”

Section: Application Of Conductive Biomaterials In Wound Healingmentioning

confidence: 99%

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

2021

View full text Add to dashboard Cite

Conductive biomaterials based on conductive polymers, carbon nanomaterials, or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity to human skin, good antioxidant and antibacterial activities, electrically controlled drug delivery, and photothermal effect. However, a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking. In this review, the design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized. The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies (electrotherapy, wound dressing, and wound assessment) were reviewed. The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound (infected wound and diabetic wound) and for wound monitoring is discussed in detail. The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.

show abstract

Section: Application Of Conductive Biomaterials In Wound Healingmentioning

confidence: 99%

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

2021

View full text Add to dashboard Cite

show abstract

“…Many biopolymers with a biodegradable nature can perform as described previously such as PCL, chitin, silk fibroin, and PLA [ 183 , 184 , 185 , 186 , 187 ]. However, the use of chitosan for controlled drug delivery has been of great interest in nanomedicine research [ 188 ].…”

Section: Drug Delivery Applications Of Bioengineered Thermo-responmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

View full text Add to dashboard Cite

Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

show abstract

“…The reconnecting of skin edges using sutures and surgical adhesives is the primary objective of wound healing (WH). On the other hand, the secondary purpose describes how a wound heals when the skin borders are not forced Gels 2023, 9, 394 2 of 21 together and the wound must close and fill with granulating tissues [7].Wound can be defined as a tear in the skin or other bodily tissues resulting from an accident or surgical incision [8][9][10]. These may be caused by a variety of forms of trauma, and it is crucial that wounds be cleansed and dressed properly in order to prevent the spread of infection and additional harm [11].…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Silico Characterization of Curcumin-Loaded Chitosan–PVA Hydrogels: Antimicrobial and Potential Wound Healing Activity

Chopra

Bibi

Mohanta

et al. 2023

Gels

View full text Add to dashboard Cite

Curcumin has been used in traditional medicine forages. The present study aimed to develop a curcumin-based hydrogel system and assess its antimicrobial potential and wound healing (WH) activity on an invitro and in silico basis. A topical hydrogel was prepared using chitosan, PVA, and Curcumin in varied ratios, and hydrogels were evaluated for physicochemical properties. The hydrogel showed antimicrobial activity against both gram-positive and gram-negative microorganisms. In silico studies showed good binding energy scores and significant interaction of curcumin components with key residues of inflammatory proteins that help in WH activity. Dissolution studies showed sustained release of curcumin. Overall, the results indicated wound healing potential of chitosan–PVA–curcumin hydrogel films. Further in vivo experiments are needed to evaluate the clinical efficacy of such films for wound healing.

show abstract

A rationalized and innovative perspective of nanotechnology and nanobiotechnology in chronic wound management

Cited by 19 publications

References 157 publications

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Conductive Biomaterials as Bioactive Wound Dressing for Wound Healing and Skin Tissue Engineering

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

In Vitro and In Silico Characterization of Curcumin-Loaded Chitosan–PVA Hydrogels: Antimicrobial and Potential Wound Healing Activity

Contact Info

Product

Resources

About