Background: The COVID-19 pandemic placed frontline nurses under great pressure, influencing their physical and psychological wellbeing. Resilience has been recognized as a protective factor in times of crisis. Purpose: Investigate the degree of resilience, and associated factors, of nurses practicing at a major public hospital and COVID-19 main referral center in Lebanon. Methods: A cross-sectional online survey investigating nurses’ demographic characteristics, job satisfaction, turnover intentions, exposure to violence, and resilience levels. Multiple linear regression was used to determine factors related to resilience. Findings: The study had a response rate of 86% and a mean resilience score of 66.91 (SD = 13.34). Nurses’ resilience is positively associated with job satisfaction and male gender and negatively associated with intention to quit and exposure to violence. Discussion: Enhancing the resilience of nurses improves their job satisfaction and retention at time of crisis, and would help support the effectiveness and efficiency of care services.