A real options approach to biotechnology investment policy—the case of developing a Campylobacter vaccine to poultry

Lund, Mogens Sandø; Jensen, Jørgen Dejgård

doi:10.1016/j.prevetmed.2016.04.006

Cited by 12 publications

(8 citation statements)

References 17 publications

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“…Vaccine would also help to reduce high cost of post-harvest treatments (Johnson et al., 2017). Nevertheless, the cost of Campylobacter infections treatment to public health systems is high thus the main motivation towards developing a Campylobacter vaccine would be to reduce the high costs of treatment associated with campylobacteriosis, enhance food safety and reduce potential human health risks (Lund and Jensen, 2016). Presently, there are no vaccines approved by any global governing authority to prevent Campylobacter infections (Riddle and Guerry, 2016).…”

Section: Campylobacter Infectionsmentioning

confidence: 99%

Human campylobacteriosis: A public health concern of global importance

Igwaran

Okoh

2019

Heliyon

241

162

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Campylobacter species are among the leading cause of bacterial foodborne and waterborne infections. In addition, Campylobacter is one of the major causative agent of bacterial gastrointestinal infections and the rise in the incidence of Campylobacter infections have been reported worldwide. Also, the emergence of some Campylobacter species as one of the main causative agent of diarrhea and the propensity of these bacteria species to resist the actions of antimicrobial agents; position them as a serious threat to the public health. This paper reviews Campylobacter pathogenicity, infections, isolation and diagnosis, their reservoirs, transmission pathways, epidemiology of Campylobacter outbreaks, prevention and treatment option, antibiotics resistance and control of antibiotics use.

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Section: Campylobacter Infectionsmentioning

confidence: 99%

Human campylobacteriosis: A public health concern of global importance

Igwaran

Okoh

2019

Heliyon

241

162

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“…However, the cost of campylobacteriosis to public health systems and the loss of labor productivity is substantial, therefore the main rationale for developing a Campylobacter vaccine would be to reduce potential human health risks, enhance food safety, and decrease the high costs associated with the disease. For the reasons described above, the need for a Campylobacter vaccine may not be driven by the market itself, but will likely require intervention by government agencies (Lund and Jensen, 2016). …”

Section: Campylobacter Vaccines For Poultry and Humansmentioning

confidence: 99%

“…Unfortunately, vaccination is expensive due to the development and manufacturing processes. These stages are costly, complex, and lengthy, and are coupled with considerable economic and technological uncertainty (Lund and Jensen, 2016). Other disadvantages associated with vaccines is that storage is costly and time limited, and adjustment of the productive capacity is slow, expensive, and overseen by regulation.…”

Section: Campylobacter Vaccines For Poultry and Humansmentioning

confidence: 99%

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

2017

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Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains. As the incidence of antibiotic resistance, emergence of post-infectious diseases, and economic burden associated with Campylobacter increases, it is becoming urgent that novel treatments are developed to reduce Campylobacter numbers in commercial poultry and campylobacteriosis in humans. The purpose of this review is to provide the current status of present and proposed treatments to combat Campylobacter infection in humans and colonization in animal reservoirs. These treatments include anti-Campylobacter compounds, probiotics, bacteriophage, vaccines, and anti-Campylobacter bacteriocins, all of which may be successful at reducing the incidence of campylobacteriosis in humans and/or colonization loads in poultry. In addition to reviewing treatments, we will also address several proposed targets that may be used in future development of novel anti-Campylobacter treatments.

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“…Using this approach in large investment projects is increasingly welcomed by researchers because of the uncertainty of costs and future revenues of investment. Real options valuation is based on theoretical principles and procedures governing the valuation of financial authorities, such as the Black-Sholes method [8,9] or binomial trees [10,11]. The use of these methods in practice is so complex due to the restrictions for the use of these methods.…”

Section: Fuzzy Pay Off Methods For Real Options Valuationmentioning

confidence: 99%

The use of fuzzy real option valuation method to rank Giga Investment Projects on Iran's natural gas reserves

Servati¹,

Ghodsypour²,

Shirazi³

2017

J. Fundam and Appl Sci.

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Giga investments are exposed to numerous systematic and unsystematic (or specific) risks that significantly influence their feasibility and value. In addition to the conventional issues and complexities in evaluating investment projects, factors such as long construction time, high amount of capital required and irreversibility of investment, increase uncertainty of cash flows in these types of projects. As a consequence, decision makers are usually not satisfied with the results of the most popular valuation methodology -discounted cash flow analysisin valuation of Giga investments. The most promising methodology of valuing flexibility in such investment projects is the real options valuation which quantifies the value of embedded flexibilities through option pricing techniques.In this paper, fuzzy real options valuation techniques are used to rank Giga project proposals faced in Iran's gas industry. To this end, different scenarios of project payoff and future uncertainties are quantified, using fuzzy numbers based on findings from earlier real option valuation methods.

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A real options approach to biotechnology investment policy—the case of developing a Campylobacter vaccine to poultry

Cited by 12 publications

References 17 publications

Human campylobacteriosis: A public health concern of global importance

Human campylobacteriosis: A public health concern of global importance

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

The use of fuzzy real option valuation method to rank Giga Investment Projects on Iran's natural gas reserves

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