A real-time 4-bit imaging electrical impedance sensing biopsy needle for prostate cancer detection

Everitt, Alicia C.; Manwaring, Preston; Halter, Ryan J.

doi:10.1117/12.2293799

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…The TRUS-array is sonolucent and all electrodes are goldplated on a flexible polyamide substrate. Further details of the BP electrodes are given in [25]. A needle guide (Fig.…”

Section: A Fused-data Treit Systemmentioning

confidence: 99%

Phantom Studies of Fused-Data TREIT Using Only Biopsy-Probe Electrodes

Murphy

Everitt

et al. 2020

IEEE Trans. Med. Imaging

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Transrectal electrical impedance tomography (TREIT) is a novel imaging modality being developed for prostate biopsy guidance and cancer characterization. We describe a novel fuseddata TREIT (fd-TREIT) system and approach developed to improve imaging robustness and evaluate it on challenging clinically-representative phantoms. The new approach incorporates 8 electrodes (in 2 rows) on a biopsy probe (BP) and 12 electrodes on the face of a transrectal ultrasound (TRUS) probe and includes a biopsy gun, instrument tracking, 3D-printed needle guide, and EIT hardware and software. The approach was evaluated via simulation, a series of prostateshaped gel phantoms, and an ex vivo bovine tissue sample using only absolute reconstructions. The simulations surprisingly found that using only biopsy-probe electrode measurements, i.e. omitting TRUS-probe electrode measurements, significantly improves robustness to noise thus leading to simpler modeling and significant decreases in computational times (~13x speed-up/reconstructions in ~27 minutes). The gel phantom experiments resulted in reconstructions with area under the curve (AUC) values extracted from receiver operator characteristic curves of > 0.85 for 4 out of the 5 tests, and when incorporating inclusion boundaries resulted in absolute reconstructions yielding 1.9% and 12.2% average percent errors for 3 consistent tests and all 5 tests, respectively. Ex vivo bovine tests revealed qualitatively that the fd-TREIT approach can largely discriminate a complex adipose and muscle interface in a realistic setting using data from 9 biopsy probe states (biopsy core locations). The algorithms developed here on challenging phantoms suggest strong promise for this technology to aid in imaging during routine 12-core biopsies.

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“…The TRUS-array is sonolucent and all electrodes are goldplated on a flexible polyamide substrate. Further details of the BP electrodes are given in [25]. A needle guide (Fig.…”

Section: A Fused-data Treit Systemmentioning

confidence: 99%

Phantom Studies of Fused-Data TREIT Using Only Biopsy-Probe Electrodes

Murphy

Everitt

et al. 2020

IEEE Trans. Med. Imaging

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“…Twenty gold-plated electrodes (size 1.5 mm × 2.0 mm) configured in a 4 × 5 grid were printed on a 1 mil polyamide substrate and secured with a pressure sensitive adhesive over the active element of the TRUS probe; the electrode array is sonolucent to provide multi-modal imaging with both TRUS and TREIT (Wan et al 2012). Four gold-plated electrodes (size 4 mm × 0.6 mm) were similarly printed on 1 mil thick polyamide substrate and secured around the BP (Everitt et al 2018). A 3D FEM mesh that matched the probe and electrode dimensions, which had roughly 500k nodes and 3M elements, (figure 2(B)) was produced using gmsh (Geuzaine and Remacle 2009).…”

Section: Experiments and Modeling Detailsmentioning

confidence: 99%

Fused-data transrectal EIT for prostate cancer imaging

Murphy

Wu²,

Halter³

2018

Physiol. Meas.

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The measured tank experiments represent important steps in the development of an algorithm that can combine EIT from multiple locations and from multiple probes-data that could be collected during a routine TRUS-guided 12-core biopsy. Overall, this result is a step towards a clinically deployable impedance imaging approach to scanning the entire prostate, which could significantly help to improve prostate cancer diagnosis.

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“…5 Although EIT does not show as much detail as computerized tomography (CT), it can detect cancer in advance by monitoring the impedance difference between normal cells and cancer cells. [6][7][8][9] Nowadays, EIT is popular in clinic trials and applications, 10 such as the real-time and long-term bedside monitoring of human lungs, including monitoring pleural effusion clearance, 11 calculating respiratory system compliance, 12 and identifying abnormal pneumatosis in the pleural cavity under mechanical ventilation. 13 The 16-electrode and 32-electrode versions are often used, mainly depending on the size of the measured object and the requirement for accuracy.…”

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confidence: 99%

A woven electrode with convex structure for electrical impedance tomography

Zhang

Zhong

Wang

et al. 2021

Textile Research Journal

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We developed a silver/silver chloride (Ag/AgCl) woven electrode, which was woven in a convex high-density structure. The convex structure can decrease the motion artifacts caused by the slippage between human skin and the electrode. The high density can reduce the noise caused by the change of contact resistance. The model of the electrode–skin interface was proposed, and its equivalent circuit model was built, which can present an intuitive understanding of electrode design principles. Furthermore, AgCl particles were electrochemically deposited on the Ag electrode in terms of 23 schemes to optimize the deposition uniformity. The effects of deposition time, electrolyte concentration, and current/voltage magnitude were investigated. According to the result, the best combination is a constant current method, with the current at 0.01 A, the deposition time set to 300 s, and the electrolyte concentration as 0.05 M. The resistances of the deposited electrodes are qualified for impedance monitoring due to their small resistance. A bioimpedance system was assembled followed by the electrical impedance tomography mechanism. The frequency response and bioimpedance–time relationship were measured and analyzed in our bioimpedance system. The result reveals that the frequency response from [Formula: see text] to[Formula: see text] Hz presents a stable state for the convex woven electrode. The woven electrode system has a wider stable frequency band than the wet electrode. The bioimpedance of wet electrodes is stable in the initial time, whereas that of woven electrodes decreases with time. However, the wet electrode bioimpedance increases with time after 3 h, and the woven electrode bioimpedance is stable after 3 h. Both the interface capacitance and resistance have very important roles in the bioimpedance system. The woven electrode is better in long-term monitoring than the wet electrode. In addition, convex electrode bioimpedance presents less noise than the plain electrode. Therefore, the convex electrode is the best choice for the bioimpedance monitoring system.

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A real-time 4-bit imaging electrical impedance sensing biopsy needle for prostate cancer detection

Cited by 4 publications

References 19 publications

Phantom Studies of Fused-Data TREIT Using Only Biopsy-Probe Electrodes

Phantom Studies of Fused-Data TREIT Using Only Biopsy-Probe Electrodes

Fused-data transrectal EIT for prostate cancer imaging

A woven electrode with convex structure for electrical impedance tomography

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