A Rebuttal to the Commentary of J. W. Hay and Z.‐Y. Zhou.Haemophilia2009; DOI:10.1111/j.1365‐2516.2009.02117.x: “Commentary on Knightet al.: A systematic review of the cost‐effectiveness of rFVIIa and APCC in the treatment of minor/moderate bleeding episodes for haemophilia patients with inhibitors”

Abstract

and àKMHO, Brighton, UK Dear Editor, As authors of ''A systematic review of the costeffectiveness of rFVIIa and APCC in the treatment of minor/moderate bleeding episodes for haemophilia patients with inhibitors'' [1], we wish to respond to and refute serious criticisms of our scientific and ethical conduct via this rebuttal to the Commentary on our paper made by Drs J. W. Hay and Z.-Y. Zhou in this issue of Haemophilia [2].While we fully accept the importance and need for open debate in the medical literature, Hay and Zhou cast aspersion on the scientific credibility of our systematic review methods, and levelled the serious allegation of data manipulation in a commentary that was unfairly damning in tone and frequently incorrect in its statements.