A Recent Achievement in the Discovery and Development of Vaccines and Therapeutic Agents in the Race for COVID-19 Protection and Treatment

Abstract

Currently, the coronavirus disease 2019 (COVID-19) is a big challenge to the healthcare systems in the world. Several researchers in the world have immediately carried out clinical investigations for the discovery of vaccines and drugs. Different studies have shown that antiviral measures including small bioactive compounds targeting multifaceted molecular communications take in COVID-19 infection. The drug development archived in this review emphasizes mainly on drugs that are effective for the Management of MERS-CoV, SARS-CoV, and other RNA viruses. The investigation of therapeutic agents for COVID-19 includes anti-inflammatory agents, antibodies, and nucleic acid-based treatments targeting virus gene expression as well as different sorts of vaccines. Numerous patents revealed techniques of these biologics with the potential for treating and preventing coronavirus infections, which may apply to COVID-19. Phase 3 clinical trials such as Sputnik V, AZD1222, mRNA-1273, BNT162b2, Ad5-nCoV, Anti-COVID antibodies, Kevzara; Actemra, Jakafi; Baricitinib, and some others were undergoing in the race for Covid-19 treatment. However, there’s still a lack of a review on vaccines and drugs for COVID-19 management. Therefore, this review summarizes different studies that are ongoing in the race for Covid-19 protection and treatment.

Real-world evidence with a retrospective cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments

“…Moreover, other studies suggested that some NSAID could have antiviral activity in coronaviruses, including SARS-CoV-2 [ 25 ], an activity demonstrated here for ibuprofen. Similarly, tranmadol is an opioid analgesic used to treat moderate to severe pain, that was initially deemed as bad prognosis [ 26 ], but further studies suggested a potential therapeutic effect [ 27 ].…”

Avaliação do conhecimento, conscientização, atitudes e perspectivas de pacientes sobre a COVID-19 e suas medidas de prevenção em consultórios odontológicos

“…Pesquisadores, laboratórios e farmacêuticas trabalharam incessantemente em busca de medicamentos e vacinas eficazes contra a doença que matava, e ainda mata, milhares de pessoas ao redor mundo diariamente (KIFLE et al, 2021;PEIFFER-SMADJA et al, 2021). A primeira dose da vacina contra a COVID-19 foi aplicada no Reino Unido em 08 de dezembro de 2020 (LOPEZ BERNAL et al, 2021).…”