A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review

Sohaimi, Norfitriah Mohamed; Hair-Bejo, M.

doi:10.5455/ovj.2021.v11.i4.6

Cited by 17 publications

(13 citation statements)

References 76 publications

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“…While the fiber-1 protein is crucial for viral replication and assembly independent of virulence potential as opposed to infectivity, and the fiber-2 protein is more crucial for FAdV pathogenicity than the hexon protein. In tissue tropism, the hexon protein is crucial ( 163 ).…”

Section: Diagnosis Of Aviadenovirusmentioning

confidence: 99%

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

et al. 2022

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Infection with fowl adenoviruses (FAdVs) can result in a number of syndromes in the production of chicken, including inclusion body hepatitis (IBH), hepatitis-hydropericardium syndrome (HHS), and others, causing enormous economic losses around the globe. FAdVs are divided into 12 serotypes and five species (A–E; 1–8a and 8b−11). Most avian species are prone to infection due to the widespread distribution of FAdV strains. The genus aviadenovirus, which is a member of the adenoviridae family, is responsible for both IBH and HHS. The most popular types of transmission are mechanical, vertical, and horizontal. Hepatitis with basophilic intranuclear inclusion bodies distinguishes IBH, but the buildup of translucent or straw-colored fluid in the pericardial sac distinguishes HHS. IBH and HHS require a confirmatory diagnosis because their clinical symptoms and postmortem abnormalities are not unique to those conditions. Under a microscope, the presence of particular lesions and inclusion bodies may provide clues. Traditional virus isolation in avian tissue culture is more delicate than in avian embryonated eggs. Additionally, aviadenovirus may now be quickly and precisely detected using molecular diagnostic tools. Preventive techniques should rely on efficient biosecurity controls and immunize breeders prior to production in order to protect progeny. This current review gives a general overview of the current local and global scenario of IBH, and HHS brought on by FAdVs and covers both their issues and preventative vaccination methods.

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Section: Diagnosis Of Aviadenovirusmentioning

confidence: 99%

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

et al. 2022

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“…The external capsid side of the hexon monomer consists of loops L1, L2, and L4, which are responsible for the antibodies’ binding, and the internal capsid side consists of two conservative pedestal domains, P1 and P2, which participate in the hexon trimer formation. The L3 loop is buried internally and stabilizes the interface between the P1 and P2 conservative regions ( 35 – 37 ). Most amino acid variations, including mutations, deletions, and additions, are located at the HVRs in the three intertwined loops L1, L2, and L4.…”

Section: Discussionmentioning

confidence: 99%

The Role of Hexon Amino Acid 188 Varies in Fowl Adenovirus Serotype 4 Strains with Different Virulence

et al. 2022

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“…The FAdV-4 capsid consists of four major structural proteins: hexon, penton base, fiber-1, and fiber-2 [10]. Functional analysis of these proteins is essential for understanding the infectivity and virulence of FAdV-4.…”

Section: Introductionmentioning

confidence: 99%

Recombinant fiber-1 protein of fowl adenovirus serotype 4 induces high levels of neutralizing antibodies in immunized chickens

et al. 2023

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Virulent fowl adenovirus serotype 4 (FAdV-4) causes hydropericardium syndrome (HPS) with high mortality in chickens, leading to significant economic losses to the poultry industry. The development of an effective vaccine is essential for successful disease control. Here, we produced recombinant fiber-1 protein of FAdV-4, isolated from a Japanese HPS outbreak strain, JP/LVP-1/96, using a baculovirus expression system and evaluated its immunogenicity and protective efficacy. Recombinant fiber-1 protein induced high levels of neutralizing antibodies in immunized chickens, which were maintained for a minimum of 10 weeks. After being challenged with the virulent FAdV-4 strain JP/LVP-1/96, the immunized chickens did not exhibit clinical signs of infection or histopathological changes, there was a significant reduction in the viral load in various organs and total serum proteins, and albumin levels did not decline. These results suggest that the recombinant fiber-1 protein produced in this study can serve as a subunit vaccine to control HPS in chickens.

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A recent perspective on fiber and hexon genes proteins analyses of fowl adenovirus towards virus infectivity - A review

Cited by 17 publications

References 76 publications

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

Epidemiology, pathology, prevention, and control strategies of inclusion body hepatitis and hepatitis-hydropericardium syndrome in poultry: A comprehensive review

The Role of Hexon Amino Acid 188 Varies in Fowl Adenovirus Serotype 4 Strains with Different Virulence

Recombinant fiber-1 protein of fowl adenovirus serotype 4 induces high levels of neutralizing antibodies in immunized chickens

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