A Recent Update: Antimicrobial Agents Containing Pyrazole Nucleus

Abstract

Objective: In this review, we report antimicrobial candidates containing pyrazole nucleus integrated with various functionalities.Methods: research results by numerous scientists have been summarized from international journals indexed in reputed database such as Scopus and Web of Science.Results: Pyrazole derivatives are much of interest as potent bioactive molecules. They have shown large bioactivities especially antimicrobial performance against broad spectrum of bacterial strains.Conclusion: Several designed pyrazole derivates possessed good to superior antimicrobial activities.

Unprecedented, catalyst‐free, and rapid one‐pot, three‐component green synthesis of substituted 3‐hydroxy‐2‐oxindoles in water

“…In the domain of biologically important heterocyclic compounds, 3-substituted 3-hydroxy-2-oxindoles molecular frameworks hold a significant space, as this molecular framework is not only found in a varied range of natural products but also in pharmaceutically important compounds which possess a broad spectrum of biological activities [14][15][16][17][18][19]. Furthermore, pyrazole heterocycle is pharmaceutically important that has been explored as a potential chemotherapeutic agent in medicinal chemistry [15][16][17][18][19][20][21][22][23]. Recently, Pablo et al reported that 3-(4-Pyrazolyl)oxindoles obtained by reaction of 5-aminopyrazoles with isatins possess potent antibacterial properties [24].…”

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“…Pyrazoles are an important class of compounds found naturally and synthesized chemically and consist of a five-membered ring with two nitrogen and three carbon atoms 8 . Because of this unique structure, they act as a scaffold and exhibit various biological activities such as anticancer, anti-inflammatory, antifungal, analgesic, antioxidant, antidepressant, hypoglycemic etc [9][10][11][12] . They also serve as lead compounds for pharmaceutical development for various applications 13 .…”

Synthesis of Antimicrobial Benzimidazole–Pyrazole Compounds and Their Biological Activities

“…Additionally, benzimidazoles treat mitochondrial dysfunction in Alzheimer’s disease [ 22 ], possess neurotropic, psychoactive, analgesic effects [ 23 ], anticoagulant proprieties [ 24 ] and are efficient agents in Diabetes mellitus [ 25 ]. Additionally, pyrazole compounds possess a diversity of biological activities as analgesic [ 26 , 27 , 28 ], anticonvulsivant [ 29 , 30 ], antitumor [ 31 , 32 , 33 , 34 ], antidiabetic [ 35 , 36 ], antimicrobial [ 37 , 38 , 39 , 40 , 41 , 42 , 43 ], antipyretic [ 44 , 45 ], antiviral [ 46 , 47 ], antimalarial [ 48 , 49 ], local anesthetic [ 50 ] and so forth.…”