A redispersible dry emulsion system with simvastatin prepared via fluid bed layering as a means of dissolution enhancement of a lipophilic drug

Pohlen, Mitja; Pirker, Luka; Luštrik, Matevž; Dreu, Rok

doi:10.1016/j.ijpharm.2018.07.064

Cited by 12 publications

(17 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The liquid emulsion composition (selection of components) and preparation were based on results from a previous article and modified in order to include insoluble matrix formers [ 12 ]. Briefly, 1OG was heated up to 40 °C in order to obtain a clear liquid and mixed with M812 in the ratio of 9:1.…”

Section: Methodsmentioning

confidence: 99%

“…The oil droplet size distribution index (SDI) is a single value index appropriate for modelling, proposed to better represent the bimodal size distribution of droplets obtained after reconstitution. The size distribution index logic is discussed in the related article and is calculated as follows [ 12 ]:

where AUC is the area under curve of the volume-based size distribution peak (expressed in volume percentage), and MAX is the maximum of the peak (expressed as size). The delimitation between the peaks used to calculate the AUC was the minimum value between the peaks.…”

Section: Methodsmentioning

confidence: 99%

“…Different manufacturing techniques have been employed for the solidification of LBDDS, from simple physical adsorption to solid carriers to more cost and energy demanding techniques, such as freeze drying and spray drying [ 10 ]. Among solid LBDDS, dry emulsions have proved to be a viable option for drug dissolution enhancement and the potential lymphatic pathway of absorption, and consequently for the drug bioavailability improvement [ 12 , 13 , 14 ]. Dry emulsions are solid LBDDS, where the outer aqueous phase of a liquid oil in a water (O/W) emulsion is replaced with a solid matrix by means of spray drying, freeze drying or pellet fluid bed coating [ 12 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Among solid LBDDS, dry emulsions have proved to be a viable option for drug dissolution enhancement and the potential lymphatic pathway of absorption, and consequently for the drug bioavailability improvement [ 12 , 13 , 14 ]. Dry emulsions are solid LBDDS, where the outer aqueous phase of a liquid oil in a water (O/W) emulsion is replaced with a solid matrix by means of spray drying, freeze drying or pellet fluid bed coating [ 12 , 15 , 16 ]. Matrix materials are mostly sugars, proteins, cellulose derivatives and inorganic materials [ 12 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dry emulsions are solid LBDDS, where the outer aqueous phase of a liquid oil in a water (O/W) emulsion is replaced with a solid matrix by means of spray drying, freeze drying or pellet fluid bed coating [ 12 , 15 , 16 ]. Matrix materials are mostly sugars, proteins, cellulose derivatives and inorganic materials [ 12 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

2021

Self Cite

View full text Add to dashboard Cite

The objective of this study was to explore the possible use of a new combination of two excipients, i.e., nanocrystalline cellulose (NCC) and macroporous silica (MS), as matrix materials for the compounding of dry emulsion systems and the effects these two excipients have on the characteristics of dry emulsion powders produced by the spray drying process. A previously developed liquid O/W nanoemulsion, comprised of simvastatin, 1-oleoyl-rac-glycerol, Miglyol 812 and Tween 20, was employed. In order to comprehend the effects that these two matrix formers have on the spray drying process and on dry emulsion powder characteristics, alone and in combination, a DoE (Design of Experiment) approach was used. The physicochemical properties of dry emulsion samples were characterised by atomic force microscopy, scanning electron microscopy, mercury intrusion porosimetry, energy-dispersive X-ray spectroscopy and laser diffraction analysis. Additionally, total release and dissolution experiments were performed to assess drug release from multiple formulations. It was found that the macroporous silica matrix drastically improved flow properties of dry emulsion powders; however, it partially trapped the oil—drug mixture inside the pores and hindered complete release. NCC showed its potential to reduce oil entrapment in MS, but because of its rod-shaped particles deposited on the MS surface, powder flowability was deteriorated.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

2021

Self Cite

View full text Add to dashboard Cite

show abstract

Hydrophobic Coating Platforms for High‐Efficiency Loading and Direct Transmembrane Delivery of Fat‐Soluble Osteogenic Drug for Enhanced Osseointegration of Titanium Implants

Chen,

Ning,

Jia

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Compared with water‐soluble osteogenic drugs, fat‐soluble osteogenic drugs exhibit higher bioavailability and drug stability, making them valuable for enhancing the osseointegration of implants. However, existing drug‐loading coatings are primarily designed for water‐soluble drugs, limiting their effectiveness in loading and delivering fat‐soluble osteogenic drugs. This study employed alkali treatment, silanization, and oleic acid acylation to sequentially modify the surface of Ti alloy, aiming to fabricate surfaces capable of efficiently loading and delivering fat‐soluble osteogenic drugs. Results show that the hydrophilicity and loading capacity of fat‐soluble osteogenic drugs strongly depended on the duration of the acylation treatment. Furthermore, the drug release mechanism involved direct diffusion from the coating to the cells in contact, resulting in improved bioavailability, as opposed to diffusion into the surrounding medium and subsequent cellular uptake. In vitro experiments using vitamine D3 (VD3) as a model drug confirmed that the coating effectively promoted bone formation through the highly efficient delivery of VD3. Furthermore, in vivo experiments demonstrated that the VD3‐loaded lipophilic surface significantly enhanced osteogenic capability and improved the osseointegration of titanium implants. This study provides a promising strategy for loading fat‐soluble drugs onto Ti implants and direct experimental evidence demonstrating the significant value of fat‐soluble drugs in promoting implant osseointegration.

show abstract

Relative bioavailability enhancement of simvastatin via dry emulsion systems: Comparison of spray drying and fluid bed layering technology

Pohlen

Zdovc

Trontelj

et al. 2022

European Journal of Pharmaceutics and Biopharmaceutics

Self Cite

View full text Add to dashboard Cite

A redispersible dry emulsion system with simvastatin prepared via fluid bed layering as a means of dissolution enhancement of a lipophilic drug

Cited by 12 publications

References 44 publications

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

The Potential of Macroporous Silica—Nanocrystalline Cellulose Combination for Formulating Dry Emulsion Systems with Improved Flow Properties: A DoE Study

Hydrophobic Coating Platforms for High‐Efficiency Loading and Direct Transmembrane Delivery of Fat‐Soluble Osteogenic Drug for Enhanced Osseointegration of Titanium Implants

Relative bioavailability enhancement of simvastatin via dry emulsion systems: Comparison of spray drying and fluid bed layering technology

Contact Info

Product

Resources

About