A refocus on the advances of single-cell biomedicine

Wang, William Yang; Wang, Xiangdong

doi:10.1007/s10565-020-09551-3

Cited by 4 publications

(6 citation statements)

References 22 publications

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“…It would be valuable to define the critical regulatory notes within the TEC gene expression network, explore their expression by multiomics, and, most importantly, to integrate regulatory nodes' expres-sion with patients' clinical phenomes by way of clinical transomics. 34,35 With the rapid development of biotechnologies, a deep understanding of the crosstalk between tumor cells and TECs at the early stage of tumorigenesis will help discover more precise and potent biomarkers and improve clinical outcomes for cancer treatment.…”

Section: To the Editormentioning

confidence: 99%

Role of endothelial cells in tumor microenvironment

Yang

Guo²,

et al. 2021

Clinical & Translational Med

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Section: To the Editormentioning

confidence: 99%

Role of endothelial cells in tumor microenvironment

Yang

Guo²,

et al. 2021

Clinical & Translational Med

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“…The deep understanding of single‐cell molecular and morphological phenomes provides new insights into the pathogenesis of human diseases and unites biological and medical science in the discipline of single‐cell biomedicine. 4 , 5 , 6 Single‐cell systems biomedicine was further advanced by multi‐dimensional and molecular explorations of single‐cell nuclear elements, signal networks, inter‐organelle communication, and metabolism using single‐cell multi‐omics and trans‐omics. 7 , 8 , 9 , 10 More recently, human single‐cell atlases have had a great impact on disease diagnosis and therapy, by discovering new cell subsets, disease‐specific biomarkers, and therapeutic targets, monitoring dynamic responses to therapy and predicting prognosis.…”

mentioning

confidence: 99%

“…With the rapid development of single‐cell technologies, single‐cell biology science has shown an impact on the identification and development of disease‐specific biomarkers. The deep understanding of single‐cell molecular and morphological phenomes provides new insights into the pathogenesis of human diseases and unites biological and medical science in the discipline of single‐cell biomedicine 4–6 . Single‐cell systems biomedicine was further advanced by multi‐dimensional and molecular explorations of single‐cell nuclear elements, signal networks, inter‐organelle communication, and metabolism using single‐cell multi‐omics and trans‐omics 7–10 .…”

mentioning

confidence: 99%

Initiative of clinical single‐cell biomedicine in clinical and translational medicine

Liu

Powell

et al. 2023

Clinical & Translational Med

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With rapid developments of single‐cell sequencing and multi/trans‐omics, clinical single‐cell biomedicine is a new and emergent discipline to integrate single‐cell molecular and clinical phenomes and uncover new disease‐specific diagnoses and therapy. The journal of Clinical and Translational Medicine (CTM) launches the first CTM initiative of clinical single‐cell biomedicine (cscBioMed) to promote the discovery and development of single‐cell‐based biology and medicine, speed the translation from single‐cell biology into clinical application, and improve early diagnosis and therapy for human diseases. The cscBioMed initiative is speeding translational processes from circulating single‐cell RNA sequencing into routine measures in clinical biochemistry of haematology, from spatial transcriptomics into single‐cell pathology, and from single‐cell‐based biomarkers and targets into clinical diagnostics and target drugs. With a clear goal, we expect that cscBioMed will benefit human health by establishing a clinical single‐cell dynamic monitoring and early predicting system and by improving diagnosis and treatment.

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“…With rapid development of single‐cell technologies, single‐cell biology science has shown impact for identification and development of disease‐specific biomarkers. The deep understanding of single‐cell molecular and morphological phenomes provides new insights for the pathogenesis of human diseases and unites biological and medical science in the discipline of single‐cell biomedicine 4–6 . Single‐cell systems biomedicine was further advanced by multi‐dimensional and molecular explorations of single‐cell nuclear elements, signal networks, inter‐organelle communication, and metabolism using single‐cell multi‐omics and trans‐omics 7–10 .…”

mentioning

confidence: 99%

Initiative of clinical single‐cell biomedicine in clinical and translational medicine

Liu

Powell

et al. 2023

Clinical and Translational Dis

Self Cite

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Background: With rapid developments of single-cell sequencing and multi/trans-omics, clinical single-cell biomedicine is a new and emergent discipline to integrate single-cell molecular and clinical phenomes and uncover new disease-specific diagnosis and therapy. Aims: The journal of Clinical and Translational Medicine (CTM) launches the first CTM initiative of Clinical Single-Cell Biomedicine (cscBioMed) to promote the discovery and development of single-cellbased biology and medicine, speed the translation from single-cell biology into clinical application, and improve early diagnosis and therapy for human diseases. Materials & Methods: The cscBioMed initiative is speeding translational processes from circulating single-cell RNA sequencing (scRNA-seq) into routine measures in clinical biochemistry of hematology, from spatial transcriptomics into single-cell pathology, from single-cell-based biomarkers and targets into clinical diagnostics and target drugs. Conclusion: With a clear goal, we expect that cscBioMed will benefit the human health by establishing a clinical single-cell dynamic monitoring and early predicting system and by improving diagnosis and treatment. Single-cell-based research has been developing for decades and has resulted in a new discipline of single-cell biology. 1-3 With rapid development of single-cell technologies, single-cell biology science has shown impact for identification and development of disease-specific biomarkers. The deep understanding of single-cell molecular and morphological phenomes provides new insights This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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A refocus on the advances of single-cell biomedicine

Cited by 4 publications

References 22 publications

Role of endothelial cells in tumor microenvironment

Role of endothelial cells in tumor microenvironment

Initiative of clinical single‐cell biomedicine in clinical and translational medicine

Initiative of clinical single‐cell biomedicine in clinical and translational medicine

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