Substantial advances in Information and Communication Technologies (ICT) bring out novel concepts, solutions, trends, and challenges to integrate intelligent and autonomous systems in critical infrastructures. A new generation of ICT environments (such as smart cities, Internet of Things,edge-fog-social-cloudcomputing, and big data analytics) is emerging; it has different applications to critical domains (such as transportation, communication, finance, commerce, and healthcare) and different interconnections via multiple layers of public and private networks, forming a grid of critical cyberphysical infrastructures. Protecting sensitive and private data and services in critical infrastructures is, at the same time, a main objective and a great challenge for deploying secure systems. It essentially requires setting up trusted security policies. Unfortunately, security solutions should remain compliant and regularly updated to follow and track the evolution of security threats. To address this issue, we propose an advanced methodology for deploying and monitoring the compliance of trusted access control policies. Our proposal extends the traditional life cycle of access control policies with pertinent activities. It integrates formal and semiformal techniques allowing the specification, the verification, the implementation, the reverse-engineering, the validation, the risk assessment, and the optimization of access control policies. To automate and facilitate the practice of our methodology, we introduce our systemSVIRVROthat allows managing the extended life cycle of access control policies. We refer to an illustrative example to highlight the relevance of our contributions.