A relationship between dengue virus serotype and the clinical severity in paediatric patients from Gondokusuman region, Yogyakarta between 1995 and 1999

Poeranto, Sri; Sutaryo, Sutaryo; Josef, Hari Kusnanto; Juffrie, Mohammad

doi:10.15557/pimr.2016.0033

Cited by 4 publications

(6 citation statements)

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“…When two or more papers described the same cohort (e.g., interim analysis), the one that had a larger sample size was selected. Most included studies started recruitment after 1997, but three studies [ 33 , 34 , 60 ] had a recruitment time window straddling 1997, and one of these was a re-analysis of a prospective cohort that was active between 1995 and 1999. [ 34 ] Eighteen studies [ 10 – 13 , 15 , 21 , 23 , 25 , 26 , 28 , 29 , 31 , 33 – 35 , 38 , 59 , 60 ] included children only while others included both adults and children or adults only.…”

Section: Resultsmentioning

confidence: 99%

“…Most included studies started recruitment after 1997, but three studies [ 33 , 34 , 60 ] had a recruitment time window straddling 1997, and one of these was a re-analysis of a prospective cohort that was active between 1995 and 1999. [ 34 ] Eighteen studies [ 10 – 13 , 15 , 21 , 23 , 25 , 26 , 28 , 29 , 31 , 33 – 35 , 38 , 59 , 60 ] included children only while others included both adults and children or adults only. The definition of children varied from those under 12 years (e.g., Sri Lanka) to less than 18 years of age (e.g., Philippines).…”

Section: Resultsmentioning

confidence: 99%

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Plasma leakage in dengue: a systematic review of prospective observational studies

et al. 2021

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Plasma leakage is a precursor to life-threatening complications of dengue, but this group is poorly defined and not often reported in literature. Patients with Dengue haemorrhagic fever (DHF) as defined in the 1997 World Health Organization classification are often reported, and they all have plasma leakage, but some patients with plasma leakage do not meet the definition of DHF. The study aims to estimate the frequency of plasma leakage and DHF (as a surrogate of plasma leakage) in dengue and its variations based on virus serotype, geography, patient gender and pre-existing immunity to dengue. PUBMED, Scopus, EMBASE, CINAHL and Web of Science were searched for prospective observational studies reporting on plasma leakage or DHF. Quality of data was assessed using the NIH quality assessment tool for cohort studies. Forty-three studies that recruited 15,794 confirmed dengue patients were eligible. Cumulative frequency of plasma leakage was 36.8% (15 studies, 1642/4462, 95% CI 35.4–38.2%), but surprisingly the estimated cumulative frequency of DHF was higher (45.7%, 32 studies, 4758/10417, 95% CI 44.7–46.6%), indicating that current medical literature over-reports DHF or under-reports plasma leakage. Therefore, a reliable estimate for the proportion of dengue patients developing plasma leakage cannot be derived from existing medical literature even after applying rigorous inclusion criteria to select homogenous studies. Plasma leakage is an important marker of “at-risk” dengue patients and standardizing its definition, diagnosis and reporting should be a priority in research and global policy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Plasma leakage in dengue: a systematic review of prospective observational studies

et al. 2021

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“…A full assessment of the 120 references resulted in the exclusion of 53 references due to the following: full texts were unavailable, and the available abstracts did not include adequate information to satisfy our outcome, the full text did not include adequate or complete serotype data, and nonstandard methods were used for serotyping. This resulted in 67 eligible studies, of which 13 references were from national journals . An additional 11 studies were included from reference list .…”

Section: Resultsmentioning

confidence: 99%

“…In total, 78 eligible studies were included for DENV serotype analysis . Of all the eligible studies, four studies were conducted based on mosquito isolates while the remaining studies assessed DENV isolates from human samples . Sixty two studies investigated dengue cases among local inhabitants of Indonesia,…”

Section: Resultsmentioning

confidence: 99%

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Harapan

Michie

Yohan

et al. 2019

Reviews in Medical Virology

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Although epidemiological and molecular epidemiological (serotype, genotype, and lineage information) data are available for several major cities in Indonesia, there is yet to be a comprehensive national study of dengue in Indonesia over time. This study was conducted to provide a comprehensive epidemiology of circulating dengue viruses (DENV) in Indonesia between 1973 and 2016. This was conducted through a systematic review of the literature and phylogenetic analysis of available DENV sequences. Available data from National Disease Surveillance System have indicated an increasing trend of dengue incidence in Indonesia over the past 50 years. Incidence rates appear to be cyclic, peaking approximately every 6 to 8 years. In contrast, the case fatality rate has decreased approximately by half with each decade since 1980.Over this 50-year time span, serotype shifts, genotype displacement within DENV-1 and DENV-2, and introduction of DENV-1 and DENV-3 genotype from other countries occurred. These events were associated with increased incidence of dengue cases. Our study also provides a valuable national snapshot of DENV genetic diversity in Indonesia that may contribute to development of more effective dengue vaccine compositions for the region.

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“…A study conducted by Endy et al 45 showed that cross-reactive memory humoral immune responses appear beneficial in symptomatic secondary DENV-3 infection but not in secondary DENV-2 or DENV-1 infection. Poeranto et al 67 showed that only DENV-3 could cause severe clinical manifestations in primary infection. In addition, a secondary infection caused by DENV-1, which is considered to induce mild symptoms, involves the risk of severe manifestation, especially if DENV-2 was the cause of the primary infection.…”

Section: Resultsmentioning

confidence: 99%

Clinical manifestation and laboratory parameters associated with progression to severe dengue in children: a systematic review and meta-analysis

Sandinirwan

Muslim

Leo

et al. 2023

Preprint

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Background: The ingenuity to predict the progression to severe dengue is crucial in managing dengue patients. The previous meta-analysis has been performed on adults, and none has been performed specifically on children. We conducted a systematic review and meta-analysis to determine the clinical manifestations and laboratory parameters associated with the progression to severe dengue according to WHO criteria. Methods: We focused on searching six medical databases for studies published from Jan 1, 2000, to Dec 31, 2020. The meta-analysis used random-effects or fixed-effects models to estimate pooled effect sizes. We also assessed the heterogeneity and publication bias. This study was registered with PROSPERO, CRD42021224439. Results: We included 49 of papers in the systematic review, and we encased the final selected 39 papers comprising 23 potential predictors in the meta-analyses. Among 23 factors studied, seven clinical manifestations demonstrated association with disease progression in children, including neurological signs, gastrointestinal bleeding, clinical fluid accumulation, hepatomegaly, vomiting, abdominal pain, and petechiae. Six laboratory parameters are associated during the early days of illness, including elevated hematocrit, elevated aspartate aminotransferase [AST], elevated alanine aminotransferase [ALT], low platelet count, low albumin levels, and elevated activated partial thromboplastin time. Dengue virus serotype 2 (DENV-2) and secondary infections were also associated with severe disease progression. Conclusion: This finding supports the use of the warning signs described in the WHO 2009 guidelines. In addition, monitoring serum albumin, AST/ALT levels, identifying infecting dengue serotypes, and immunological status could improve the risk prediction of disease progression. Keywords: children, dengue, risk prediction, severity, warning sign.

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A relationship between dengue virus serotype and the clinical severity in paediatric patients from Gondokusuman region, Yogyakarta between 1995 and 1999

Cited by 4 publications

References 0 publications

Plasma leakage in dengue: a systematic review of prospective observational studies

Plasma leakage in dengue: a systematic review of prospective observational studies

Dengue viruses circulating in Indonesia: A systematic review and phylogenetic analysis of data from five decades

Clinical manifestation and laboratory parameters associated with progression to severe dengue in children: a systematic review and meta-analysis

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