A Relevance Study of Bone Marrow Aspiration and Bone Marrow Biopsy in Haematological and Non Haematological Disorders

Khatik, Dr Daleep Kumar

doi:10.18535/jmscr/v5i4.184

Cited by 3 publications

(7 citation statements)

References 12 publications

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“…However, aspiration was dry tap in 4.17% cases whereas biopsy was cellular. The most common anaemia encountered was megaloblastic anaemia, which was comparable with the studies by Khatik, et al [4], Atchyuta, et al [9], Birare, et al [10], Bashir, et al [11], and Mehra, et al [12]. The second commonest anaemia encountered was aplastic anaemia, which was in concordance with the studies by Khatik, et al [4], Atchyuta, et al [9], and Mehra, et al [12].…”

Section: Resultssupporting

confidence: 89%

“…The majority of cases encountered were haematological disorders accounting for 92% followed by 6% of nonhaematological disorders and 2% were normal bone marrow. These findings were in concordance with various studies by Mahajan, et al [3], Khatik, et al [4] and Goyal, et al [5]. The age range was between 9 to 2020.…”

Section: Discussionsupporting

confidence: 93%

“…The most common MPN encountered in the present study was Chronic Myeloid Leukaemia (CML) accounting for 62.5% of cases, followed by Polycythaemia Vera (PV) in 18.75% of cases, 6.25% cases each of Essential Thrombocythemia (ET), Myelofibrosis (MF) and Myeloproliferative Neoplasm-unclassified (MPN-U). In the studies conducted by Khatik, et al [4] and Atchyuta, et al [9], the most common disorder encountered was CML as in the present study.…”

Section: Resultssupporting

confidence: 60%

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Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Gaurvi¹,

Teerthanath²

2022

Int J Pathol Clin Res

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Context: Bone marrow examination is an important diagnostic tool widely used in various haematological and non-haematological disorders. Bone marrow evaluation may either confirm clinically suspected disease or may provide the previously unsuspected diagnosis.Objectives: To study the spectrum of lesions, comparison and evaluation of diagnostic efficacy of the bone marrow aspiration and bone marrow biopsy findings in various haematological and non-haematological disorders.Design: A prospective study on 100 cases of bone marrow aspiration and biopsy was conducted between January 2019 to June 2020. Conclusion:This study concludes that bone marrow aspiration and biopsy are complementary to each other in diagnosing various haematological and non-haematological disorders. Therefore, simultaneous evaluation of both ensures accurate diagnosis, and further management.

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Section: Resultssupporting

confidence: 89%

Section: Discussionsupporting

confidence: 93%

Section: Resultssupporting

confidence: 60%

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Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Gaurvi¹,

Teerthanath²

2022

Int J Pathol Clin Res

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“…[15] Cases diagnosed on bone marrow biopsy alone in present study were of primary and secondary myelofibrosis in CML this is comparable to the study done by Hota R et al (2017) where the finding were same. [16] In a study by Khatik D (2017), [7] there were 6 (4%) cases diagnosed as multiple myeloma. Male to female ratio was 1:1.…”

Section: Discussionmentioning

confidence: 98%

“…There are very few studies on the bone marrow in this age group patients showing the profile of hematological and non-hematological disorders some of them are Mahajan V et al (2013) and Khatik D et al (2017). [6,7] A few studies have been done on the bone marrow profile across wider age groups in specific disorders like Pancytopenia (Sindhu et al) (2016), [8] NHL infiltration (Musolino A et al) (2010), [9] Hodgkin lymphoma (Moid F et al) (2005), [10] PUO (Ben-Baruch et al) (2012), [11] multiple myeloma (Stifter S et al) (2010), [12] metastasis in the bone marrow (Mehdi SR et al) (2011). [13] Out of the 100 cases of hematological disorders in the present study, the most common diagnosis in this age group is anemia in 53% of the cases followed by Leukemia in 14%.…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Bone Marrow Aspiration and Bone Marrow Trephine Biopsy in Haematological and Non-Haematological Disorders

Goyal¹,

Kundal²,

Singh³

et al. 2018

AIMDR

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Background: This study was conducted in the Department of Pathology, GMC Patiala on 100 patients over period of three years with the objective to study the comparison of the bone marrow aspiration and bone marrow trephine biopsy in haematological and non-haematological disorders in elderly age patients.(Age >50years). Methods: 100 cases with different hematological and non-hematological problems were taken up for the present study with age >50 years. Salah"s bone marrow aspiration needle and Jamshidi's bone marrow biopsy needle were used to collect the samples. For staining Leishmann's and H&E stains were used. Results: Majority of the cases were in the age of 50-60. Majority of haematological disorders comprised of anaemia (62%), leukemia(17.7%), multiple myeloma (7.5%), primary myelofibrosis(2.5%), myeloproliferative disorders(2.5%), hypocellular marrow (2.5%), increased eoisinophils and precurcors(1.2%), NHL (1.2%) lymphocytosis(1.2%) and plasmacytosis (1.2%). Both of the 2 cases of nonhaematological disorders were of metastatic carcinomatous deposists. Conclusion: The bone marrow aspiration and trephine biopsy were comparative in most of the haematological disorders except in primary and secondary myelofibrosis where biopsy provided clue to the diagnosis. Non-haematological disorders showed the same findings.

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Utility of bone marrow aspiration and trephine biopsy in various haematological malignancies

Thakur

Thaker

et al. 2023

Int J Res Med Sci

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Background: The bone marrow examination is a useful and cost-effective diagnostic procedure in haematological practice for the diagnosis of haematological disorders. It may either confirm the clinically suspected disease or may provide the previously unsuspected diagnosis. The bone marrow examination can be done by bone marrow aspiration as well as by performing bone marrow biopsy. The aim of the study is to compare the diagnostic accuracy and rate of concordance between two modalities of bone marrow examination in diagnosis of haematological malignancies. Methods: The study was conducted at haematology section of the Department of Pathology, Government Medical College, Jammu spanned over a period of 2.5 years from June 2020 to December 2022. The clinical data along with physical examination, relevant haematological, biochemical and radiological investigations were also reviewed. After taking the informed consent bone marrow aspiration and bone marrow biopsy were done under aseptic precautions. Results: A total of 250 cases of haematological malignancies were studied over a 2.5 year period. The most common haematological malignancy was found to be leukemia 194 (77.6%) cases, followed by plasma cell dyscrasia with 30 (12%) cases, lymphomas and myeloproliferative disorders each with 11 (4.4%) cases and metastatic deposits 4 (1.6%) cases. In the present study, 64/250 (25.6%) patients underwent BMA and trephine biopsy simultaneously. A positive concordance was seen in 46 (71.8%) of the cases between the two methods and diagnostic discordance was observed in 10 (16.3%) of the cases. Conclusions: Bone marrow aspiration and biopsy both complement each other and should be evaluated simultaneously. This study emphasizes the need for greater vigilance in the early diagnosis and an interdisciplinary approach for the effective management of patients as well as inclusion of trephine biopsy as regular procedure for complete evaluation of patients with haematological malignancies.

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A Relevance Study of Bone Marrow Aspiration and Bone Marrow Biopsy in Haematological and Non Haematological Disorders

Cited by 3 publications

References 12 publications

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Comparative Study of Bone Marrow Aspiration and Bone Marrow Trephine Biopsy in Haematological and Non-Haematological Disorders

Utility of bone marrow aspiration and trephine biopsy in various haematological malignancies

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