A renaissance in low-level laser (light) therapy – LLLT

Mandel, Arkady; Hamblin, Michael R.

doi:10.1515/plm-2012-0044

Cited by 14 publications

(15 citation statements)

References 26 publications

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“…LLLT is defined as a drug‐free, noninvasive and safe form of light therapy based on nonionizing radiation inducing nonthermal responses involving endogenous chromophores, finally resulting in photophysical and photochemical biological events .…”

Section: Low‐level Laser Therapymentioning

confidence: 99%

“…Moreover, it is well known that a less than optimal key parameters setting could finally result in reduced effectiveness or even in a negative outcome. Such heterogeneous results are due to LLLT intrinsic biphasic dose response, directly correlating with the characteristics of the used wavelength and the amount of energy absorbed by the photoacceptors, as well as the energy density (light fluence) .…”

Section: Low‐level Laser Therapymentioning

confidence: 99%

“…The biological biphasic dose response to light stimulation is described by the “Arndt‐Schulz law”, stating that while a weak stimulus can have positive effect, a stronger stimulation should result in the same biological response inhibition or even suppression. Its biological importance has been widely demonstrated using both in vitro and in vivo models, as well as in clinical trials .…”

Section: Low‐level Laser Therapymentioning

confidence: 99%

“…Another setting to be take into account when defining LLLT operational setting, is light irradiation modality, as pulsed light stimulation results in biological and clinical effects different from that obtained with continuous wave light stimulation. Such difference is mainly due to the observation that pulsed light could better penetrate melanin and other skin barriers, thus allowing deeper tissues targeting .…”

Section: Low‐level Laser Therapymentioning

confidence: 99%

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Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways

Migliario

Sabbatini

Mortellaro

et al. 2018

Journal of Biophotonics

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Lasers devices are widely used in various medical fields (eg, surgery, dermatology, dentistry, rehabilitative medicine, etc.) for different applications, ranging from surgical ablation of tissues to biostimulation and pain relief. Laser is an electromagnetic radiation, which effects on biological tissues strongly depends on a number of physical parameters. Laser wavelength, energy output, irradiation time and modality, temperature and tissue penetration properties have to be set up according to the clinical target tissue and the desired effect. A less than optimal operational settings, in fact, could result in a null or even lethal effect. According to the first law of photobiology, light absorption requires the presence of a specific photoacceptor that after excitation could induce the activation of downstream signaling pathways. Low-level lasers operating in the red/near infrared portion of the light spectra are generally used for biostimulation purposes, a particular therapeutic application based on the radiant energy ability to induce nonthermal responses in living cells. Biostimulation process generally promotes cell survival and proliferation. Emerging evidences support a low-level laser stimulation mediated increase in "good" reactive oxygen species, able to activate redox sensitive signal transduction pathways such as Nrf-2, NF-kB, ERK which act as key redox checkpoints.

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Section: Low‐level Laser Therapymentioning

confidence: 99%

Section: Low‐level Laser Therapymentioning

confidence: 99%

Section: Low‐level Laser Therapymentioning

confidence: 99%

Section: Low‐level Laser Therapymentioning

confidence: 99%

See 2 more Smart Citations

Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways

Migliario

Sabbatini

Mortellaro

et al. 2018

Journal of Biophotonics

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“…Several studies have revealed that PBM in a pulsed‐wave mode of operation is substantially better able to penetrate through the melanin and other skin barriers, supporting the hypothesis that pulsing is beneficial in reaching deep target tissue . While CW and standard pulsed lasers are limited to <1–2 cm therapeutic efficient penetration, super‐pulsed IR laser technology is able to show therapeutic efficacy at up to 10 cm into tissue and benefits target tissues, such as bones, tendons, ligaments, and cartilage …”

Section: Laser Parameters For Effective Treatmentmentioning

confidence: 99%

Photobiomodulation in oral medicine: a review

Pandeshwar

Roa

Das

et al. 2015

J of Invest & Clin Dent

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Photobiomodulation (PBM) or low-level laser therapy (LLLT) in dentistry is an evolving science, with an increasing number of controlled clinical studies exploring its potential as a treatment modality. The present study provides an outline of the biologic mechanism of PBM and summarizes the findings of clinical studies of PBM for specific applications in oral medicine. Controversies and drawbacks associated with PBM, which require further research, are also identified. Current literature reports the potential of PBM in various applications in oral medicine. Furthermore, well-documented research confirms its efficacy in certain conditions, such as oral mucositis, recurrent herpes simplex infection, and burning mouth syndrome. The absence of any reported adverse effects is an advantage over conventional therapeutic modalities. While PBM has proved to be effective for some specific applications, it is not a panacea. The paucity in standardized studies, coupled with ambiguity over the laser parameters, has limited its credibility as a therapeutic modality.

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The Role of Veterinary Technicians and Nurses in Laser Therapy

Houyoux

Kortelainen²

2017

Laser Therapy in Veterinary Medicine

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A renaissance in low-level laser (light) therapy – LLLT

Cited by 14 publications

References 26 publications

Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways

Near infrared low‐level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways

Photobiomodulation in oral medicine: a review

The Role of Veterinary Technicians and Nurses in Laser Therapy

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