A repeated measures cognitive affective bias test in rats: comparison with forced swim test

Aliphon, Benjamin; Dai, Twain; Moretti, Jessica; Penrose-Menz, Marissa; Mulders, Wilhelmina; Blache, Dominique; Rodger, Jennifer

doi:10.1007/s00213-022-06281-8

Cited by 4 publications

(1 citation statement)

References 54 publications

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“…To determine if motor changes in FST and TST reflect these effects, a comparative analysis with cognitive affective bias (CAB) tests could be beneficial. Despite one study that reported no correlation between FST results and CAB (Aliphon et al, 2022 ), further research is required to investigate this relationship.…”

Section: Depression-related Constructsmentioning

confidence: 96%

Rodent tests of depression and anxiety: Construct validity and translational relevance

Gencturk,

Unal

2024

Cogn Affect Behav Neurosci

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Behavioral testing constitutes the primary method to measure the emotional states of nonhuman animals in preclinical research. Emerging as the characteristic tool of the behaviorist school of psychology, behavioral testing of animals, particularly rodents, is employed to understand the complex cognitive and affective symptoms of neuropsychiatric disorders. Following the symptom-based diagnosis model of the DSM, rodent models and tests of depression and anxiety focus on behavioral patterns that resemble the superficial symptoms of these disorders. While these practices provided researchers with a platform to screen novel antidepressant and anxiolytic drug candidates, their construct validity—involving relevant underlying mechanisms—has been questioned. In this review, we present the laboratory procedures used to assess depressive- and anxiety-like behaviors in rats and mice. These include constructs that rely on stress-triggered responses, such as behavioral despair, and those that emerge with nonaversive training, such as cognitive bias. We describe the specific behavioral tests that are used to assess these constructs and discuss the criticisms on their theoretical background. We review specific concerns about the construct validity and translational relevance of individual behavioral tests, outline the limitations of the traditional, symptom-based interpretation, and introduce novel, ethologically relevant frameworks that emphasize simple behavioral patterns. Finally, we explore behavioral monitoring and morphological analysis methods that can be integrated into behavioral testing and discuss how they can enhance the construct validity of these tests.

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Section: Depression-related Constructsmentioning

confidence: 96%

Rodent tests of depression and anxiety: Construct validity and translational relevance

Gencturk,

Unal

2024

Cogn Affect Behav Neurosci

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Innovating translational models of affective disorders

Robinson,

Bangasser

2023

Psychopharmacology

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Benincasa Hispida Reversed D-galactose-induced oxidative Stress And Neurodegeneration-Mediated Cognitive Impairment In Aged Rats.

RC,

2023

Preprint

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Introduction: Age-related cognitive impairment is a common issue that is frequently brought on by oxidative stress and neurodegeneration in the brain. D-gal is a sugar moiety that has been linked to aging and cognitive disorders. This disease's prevalence is expected to rise linearly by 2050. Material & methods: Benincasa hispida, commonly known as wax gourd or winter melon, is a widely consumed vegetable with various medicinal properties. it belongs to the family of Cucurbitaceae. This study evaluates the neuroprotective role of a hydro-ethanolic seed extract of Benincasa hispida(BH) against D-gal-induced aging in rats. Healthy male rats were divided into six groups: The control group received normal saline, donepezil (2 mg/kg b.w.t., i.p.); D-gal (300 mg/kg b.w.t., i.p.); D-gal +BH (150 mg/kg b.w.t., o.p.); D-gal BH (250 mg/kg b.w.t., o.p.); and D-gal BH (300 mg/kg b.wt. Results and discussion: Behavioural, brain biochemical, and histopathological changes were assessed after treatment. The results of the behavioral study depicted that D-gal significantly reduces spontaneous alternation and locomotor activity, indicating behavioral and cognitive impairment. Biochemical studies showed that D-gal significantly increases oxidative stress in rat brains. Histopathological study showed that D-gal disturbs the normal architecture of hippocampal and cortical cells, indicating degeneration in these brain areas. D-gal and BH co-treatment for 42 days attenuated the behavioral, biochemical, and neuroanatomic damages caused by D-gal; it markedly suppressed the D-gal-induced oxidative stress and AChE activity in the brain and maintained the normal cellular architecture in hippocampal and cortical areas. Conclusion: Thus, this study shows that BH can protect the brain from the adverse effects of D-gal (e.g., memory loss and cognitive impairment) by modulating oxidative stress.

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A repeated measures cognitive affective bias test in rats: comparison with forced swim test

Cited by 4 publications

References 54 publications

Rodent tests of depression and anxiety: Construct validity and translational relevance

Rodent tests of depression and anxiety: Construct validity and translational relevance

Innovating translational models of affective disorders

Benincasa Hispida Reversed D-galactose-induced oxidative Stress And Neurodegeneration-Mediated Cognitive Impairment In Aged Rats.

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