A report on clinical importance of serum glycoconjugates in oral cancer

Baxi, Bina R.; Patel, Prabhudas S.; Adhvaryu, Siddharth G.

doi:10.1007/bf02873502

Cited by 7 publications

(13 citation statements)

References 13 publications

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“…Our study showed that there is an increase in the both salivary and serum sialic acid levels in the free state as well as in protein-bound state from precancer to cancer and supports the same trend observed in the studies by Baxi et al 4 Patel. 27 Raval et al 28 Rajpura et al 29 Stoyloff J et al 30 Sanjay PR et al 31 This can be explained by the fact that there are alterations in cellular mechanisms pertaining to glycosylation seen during the oncogenesis.…”

Section: Discussionsupporting

confidence: 92%

“…This is attributed to spillage of the sialic acid directly into circulation by the metastasized tumour islands. 30 Iptonma et al 33 Harvey et al 34 Baxi et al 4 Patel et al 27 and Raval G. 35 have found that sialic acid levels increases progressively with metastasis of oral squamous cell carcinoma. Increasing levels of sialic acid causes decreased cell adhesion due to repulsive effects of the negatively-charged sialic acid causing increased cell mobility and lack of cohesion.…”

Section: Discussionmentioning

confidence: 99%

“…One such glycoprotein gaining acceptance as a serological marker for OSCC diagnosis is sialic acid. 4 Recent studies have been directed towards the estimation of levels of Total Sialic Acid (TSA), Free Sialic Acid (FSA), Protein-bound Sialic Acid (PBSA) and Lipid-Associated Sialic Acid (LASA) in premalignant and malignant lesions. 5,6 The present study was an attempt to correlate the FSA and PBSA levels in saliva and serum in groups of subjects with tobacco habit, some of whom may manifest oral premalignant lesions or oral cancer.…”

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confidence: 99%

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Micronuclei and sialic acid as markers of genotoxic damage in tobacco-related oral lesions

et al. 2013

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Background: Carcinogens and co-carcinogens act in an additive, synergistic and antagonistic manner. Tobacco is the most common carcinogen related to oral cancer. The aim of this study was to assess the effect of tobacco on the oral epithelium by evaluating genotoxic damage to cells as quantitated by micronuclei and also the alterations to the cell membrane were correlated by the measurement of free sialic acid and protein-bound sialic acid in saliva and in serum. Materials and Methods:Blood samples collected from 15 untreated oral squamous cell carcinoma patients, 15 patients with oral precancerous conditions, 15 tobacco chewers without clinically evident lesion and 15 non-tobacco chewers. Serum and salivary sialic acid levels both in free and bound form were measured spectrophotometrically. Smear was taken from the same patient from the suspicious site and assessment of micronuclei was done by acridine orange method. Conclusion:Micronuclei, serum and salivary sialic acid levels may be a good marker for prediction of premalignancy and oral squamous cell carcinoma transformation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Micronuclei and sialic acid as markers of genotoxic damage in tobacco-related oral lesions

et al. 2013

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“…Baxi et al .,[21] Baxi et al .,[7] Rao et al .,[23] Raval et al .,[24] Rajpura et al .,[2] and Joshi and Patil[25] demonstrated elevated levels of serum sialic acid in oral cancer group as compared to premalignant and control group. Xing et al .…”

Section: Discussionmentioning

confidence: 99%

Estimation of salivary sialic acid in oral premalignancy and oral squamous cell carcinoma

et al. 2016

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Aims:Oral cancer is the most life-threatening disease of oral tissues. In societies where the incidence of oral cancer is high, clinically recognizable premalignant lesions are particularly common. Diagnosing oral cancers at an early stage is critical in improving the survival rate and reducing the morbidity associated with the disease. Alterations in the sialic acid levels in cancer patients have stimulated interest in this sugar residue as a possible tumor marker.Settings and Design:The purpose of this study was to estimate the salivary sialic acid levels in patients with oral premalignancy and squamous cell carcinoma and to correlate it with their grades to develop a cost-effective and noninvasive diagnostic parameter.Materials and Methods:Unstimulated whole saliva was collected from the groups under study and subjected to biochemical analysis for determination of sialic acid levels.Statistical Analysis Used:The salivary sialic acid levels were correlated with the clinical stage and histological grade by one-way ANOVA (SPSS software version 15).Results:Salivary sialic acid was elevated in oral squamous cell carcinoma (OSCC) compared to oral premalignancy and control group. A statistically significant correlation was observed between the grades of squamous cell carcinoma, grades of dysplasia in premalignancy, and sialic acid level.Conclusion and Clinical Significance:Evaluation of salivary sialic acid levels in premalignant and malignant lesions can serve as a screening tool. The mortality and morbidity of OSCC can be reduced if the lesions are diagnosed in early precancerous states using such noninvasive diagnostic methods for screening and monitoring of the population.

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“…[8] Usefulness of serum sialic acid as a biomarker for various malignancies, including oral cancer is well established and was found to be well correlated with tumor progression or reduction in tumor mass and recurrence or metastasis in oral cancer. [6,[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] Saliva being a biofluid, which is a filtrate of serum from the vasculature that nourishes the salivary glands, any change that occurs in the serum as a result of disease process will be reflected in saliva. [27] However, studies in this direction particularly related to glycoconjugate components, such as sialic acid, are very few in the literature.…”

Section: Introductionmentioning

confidence: 99%

Serum and salivary sialic acid as a biomarker in oral potentially malignant disorders and oral cancer

et al. 2014

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Background: Aberrant glycosylation is the universal feature of cancer and components of various glycoconjugates, such as sialic acid is found to rise in various malignancies. The objective of this study was to evaluate the serum and salivary sialic acid in oral potentially malignant disorders (OPMD) and oral cancer (OC) to investigate the possibility of using this as a diagnostic marker. Materials and Methods: The study included 85 subjects, who were grouped as control (30), OPMD patients (25), and oral cancer patients (30). Serum and unstimulated whole saliva was collected from subjects of all groups and sialic acid estimation was done using spectrophotometry. The results were tabulated and analyzed statistically. Results: The mean serum sialic acid levels in normal, OPMD, and oral cancer group were 7.515, 19.620, and 55.235 mg/dL, respectively, whereas the levels of salivary sialic acid were 1.5113, 2.3302, and 9.0304 mg/dL, respectively. A very highly significant rise (P < 0.005) in serum and salivary sialic acid was observed in the study subjects compared with that of the control. Conclusions: The present study showed a significant and gradual increase in serum and salivary sialic acid from control to oral potentially malignant disorders to oral cancer. From this study we can suggest that sialic acid can be used as a reliable biomarker. As this monosaccharide is observed in saliva in detectable quantity, saliva can be used as a diagnostic medium for screening and early detection of oral cancer.

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A report on clinical importance of serum glycoconjugates in oral cancer

Cited by 7 publications

References 13 publications

Micronuclei and sialic acid as markers of genotoxic damage in tobacco-related oral lesions

Micronuclei and sialic acid as markers of genotoxic damage in tobacco-related oral lesions

Estimation of salivary sialic acid in oral premalignancy and oral squamous cell carcinoma

Serum and salivary sialic acid as a biomarker in oral potentially malignant disorders and oral cancer

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