A report on the incidence of intestinal 99mTc-methylene diphosphonate uptake of bone scans and a review of the literature

Ergün, Eser Lay; Kıratlı, Pınar Özgen; Günay, Emel Ceylan; Erbaş, Belkıs

doi:10.1097/01.mnm.0000237991.44948.13

Cited by 25 publications

(18 citation statements)

References 11 publications

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“…Standard SPECT examination does not allow for full quantity assessment of regional accumulation of osteotropic isotope activity [4–6]. Quantitative evaluation of bone metabolism is possible with the use of SPECT/CT technique [5–7]. The obtained results demonstrate that the radioisotopic method of spine examination SPECT/CT with 99m Tc-MDP is helpful for defining bone metabolism and therapy effects.…”

Section: Discussionmentioning

confidence: 99%

Radioisotopic assessment of bone metabolism of the operated vertebra after inter-process stabilizer implantation in the lumbar segment of the spine

Radek¹,

Radek²,

Rysz³

et al. 2017

aoms

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IntroductionLack of efficacy of pharmacotherapy and physiotherapy in spinal pain syndrome is an indication for intervertebral stabilizer implantation between the processes in the lumbar segment of the spine.Material and methodsThe group consisted of 32 patients qualified after radioisotopic single-photon emission computed tomography/computed tomography (SPECT/CT) examinations with assessment of bone metabolism and mineral density. For comparative purposes, the L2 vertebra was defined as normal. Parameters defined in the area of operated vertebrae were comparable to L2. Imaging examinations and a pain intensity test were performed before and 12 months after the procedure.ResultsIn SPECT, osteotropic isotope (OI) activity in spinous bodies and processes was close to L2 values. Density assessed in CT of analysed vertebrae was close to L2. In the control examination, activity of OI in spinous bodies and processes was higher in the procedure area. Under the stabilizer, there was a strong positive correlation with the L2 parameters. The differences were statistically significant (p = 0.0002). The increase of OI activity in the elements above the stabilizer was variable. In the control examination, there was higher density of spinous processes and bodies above and under the stabilizer. The difference, compared to the L2 density, was statistically significant.ConclusionsThe radioisotopic method with SPECT/CT allows for the precise assessment of bone metabolism in the spine. After the procedure, a negative correlation was observed between bone metabolism changes and pain intensity test results.

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Section: Discussionmentioning

confidence: 99%

Radioisotopic assessment of bone metabolism of the operated vertebra after inter-process stabilizer implantation in the lumbar segment of the spine

Radek¹,

Radek²,

Rysz³

et al. 2017

aoms

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“…Selon une étude portant sur 2144 patients, environ 1 % des patients présentaient des fixations intestinales et le côlon ascendant constituait le site de fixation le plus fréquent. Ces fixations ectopiques sont en général intermittentes et peuvent très bien ne correspondre à aucune pathologie digestive [3]. L'acte réflexe devant cette situation inattendue de fixation du cadre colique est de procéder à un contrôle de qualité de la trousse radiopharmaceutique ayant servi à explorer le patient surtout si des fixations ectopiques autres qu'intestinales ont été visualisées.…”

Section: Discussionunclassified

Fixation intestinale de radiobiphosphonates dans un cas de maladie de Crohn

et al. 2015

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“…This uptake in soft-tissue is believed to be due to chemisorption of Tc-99m MDP on the surface of calcium salts, including hydroxyapatite crystals. [2] Probable mechanisms of increased soft-tissue calcium deposition are as follows:[2]…”

Section: Discussionmentioning

confidence: 99%

Technetium-99m-methylene Diphosphonate Uptake in Hepatic Necrosis Secondary to Respiratory Failure

Mahajan¹,

Digamber²,

Sharma³

2013

World J Nucl Med

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Tc-99m methylene diphosphonate (MDP) bone scintigraphy has long been used for the evaluation of benign as well as malignant skeletal conditions. However, non-osseous tracer uptake on a bone scan is an unusual finding. On one hand, there is a need for awareness of the pathophysiologic basis underlying such uptake, as it may be of critical clinical relevance in the evaluation of the patient. On the other hand, some alterations in biodistribution may be of little clinical significance, but have deleterious consequences on the quality of the bone study. Recognition of these abnormalities will reduce errors and provide important clinical information. We described a case of 57-year-old male patient with history of carcinoma base of tongue, where a 99mTc-MDP bone Scintigraphy was performed for metastasis survey. It revealed avascular necrosis of head of right femur. In addition incidentally demonstrated diffuse increased pathologic uptake of Tc-99m-MDP in the liver and multiple foci in bilateral lungs. This article reviews several possible reasons for such diffuse hepatic uptake. In the present case diffuse hepatic necrosis secondary to respiratory failure due to bilateral miliary pulmonary metastasis is considered to be the cause of the diffuse liver uptake of 99mTc-MDP.

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A report on the incidence of intestinal 99mTc-methylene diphosphonate uptake of bone scans and a review of the literature

Cited by 25 publications

References 11 publications

Radioisotopic assessment of bone metabolism of the operated vertebra after inter-process stabilizer implantation in the lumbar segment of the spine

Radioisotopic assessment of bone metabolism of the operated vertebra after inter-process stabilizer implantation in the lumbar segment of the spine

Fixation intestinale de radiobiphosphonates dans un cas de maladie de Crohn

Technetium-99m-methylene Diphosphonate Uptake in Hepatic Necrosis Secondary to Respiratory Failure

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