A research update on the antitumor effects of active components of Chinese medicine ChanSu

Jia, Jinhao; Li, Jie; Zheng, Qiusheng; Li, Defang

doi:10.3389/fonc.2022.1014637

Cited by 24 publications

(15 citation statements)

References 129 publications

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“…Modern research shows that it has various pharmacological activities such as cardiotonic, antitumor, analgesic, anti-inflammatory, and immune regulation ( Zhan et al, 2020 ). Bufadienolides are the most important bioactive substances in Chan Su, including bufalin, bufotalin, cinobufagin, cinobufotalin, telocinobufagin, etc ( Jia et al, 2022 ). They can effectively combat various cancers such as liver cancer, osteosarcoma, colorectal cancer, gastric cancer, lung cancer, and breast cancer.…”

Section: Resultsmentioning

confidence: 99%

Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives

Liao,

Wei,

et al. 2024

Front. Pharmacol.

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Hepatocellular carcinoma (HCC) has a high morbidity and mortality rate, and the survival rate of HCC patients remains low. Animal medicines have been used as potential therapeutic tools throughout the long history due to their different structures of biologically active substances with high affinity to the human body. Here, we focus on the effects and the mechanism of action of animal-derived natural products against HCC, which were searched in databases encompassing Web of Science, PubMed, Embase, Science Direct, Springer Link, and EBSCO. A total of 24 natural products from 12 animals were summarized. Our study found that these natural products have potent anti-hepatocellular carcinoma effects. The mechanism of action involving apoptosis induction, autophagy induction, anti-proliferation, anti-migration, and anti-drug resistance via phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR), Ras/extracellular signal regulated kinases (ERK)/mitogen-activated protein kinase (MAPK), Wnt/β-catenin, and Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways. Huachansu injection and sodium cantharidate have been used in clinical applications with good efficacy. We review the potential of animal-derived natural products and their derivatives in the treatment of HCC to date and summarize their application prospect and toxic side effects, hoping to provide a reference for drug development for HCC.

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Section: Resultsmentioning

confidence: 99%

Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives

Liao,

Wei,

et al. 2024

Front. Pharmacol.

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“…It should be mentioned that all the approved drugs contain the extraction of toad venom but not the isolated active components such as these discussed bufadienolides in this review. For example, while Chansu injection, an approved drug in China for infective diseases, has been evaluated for its potential in cancer treatment, its effectiveness and safety among cancer patients are yet to be proved ( Jia et al, 2022 ). A clinical study, published in 2016 in stage III-IV patients of non-Hodgkin lymphoma, showed that the combination of Chansu injection with EOAP (etoposide, vincristine, cytosine arabinoside and prednisone) failed to improve the therapeutic effect when compared to EOAP group ( Niu et al, 2016 ).…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…These compounds are structurally related, and specially, all of them can be regarded as bufalin’s derivatives, with minor differences at certain position, which are shown and highlighted in Figure 2 . It appears that TVAs have broad-spectrum anticancer potential ( Liu et al, 2019 ; Niu et al, 2021 ; Jia et al, 2022 ). Research has indicated that they, either by single use or as a mixture when combined with other agents, are effective in treating acute myeloid leukemia ( Hirasaki et al, 2022 ), lung cancer ( Xie et al, 2018 ; Li et al, 2021b ; Meng et al, 2021 ), colorectal cancer ( Li et al, 2019 ; Bai et al, 2021 ; Meng et al, 2021 ), liver cancer ( Zhang et al, 2012 ; Zhao et al, 2019 ; Zhang et al, 2020b ; Yang et al, 2021b ), breast cancer ( Zhu et al, 2018 ), oral cancer ( Jo et al, 2021 ), gastric cancer ( Xiong et al, 2019 ), Ehrlich ascites carcinoma ( Giri et al, 2018 ), melanoma ( Pan et al, 2019 ; Zhang et al, 2020c ; Kim et al, 2020 ), nasopharyngeal carcinoma ( Pan et al, 2020 ; Hou et al, 2022 ), osteosarcoma ( Cao et al, 2017 ; Dai et al, 2018b ; Zhang et al, 2019a ), cholangiocarcinoma ( Ren et al, 2019 ), myeloma ( Baek et al, 2015 ), etc.…”

Section: Bufadienolides In Toad Venom and Their Therapeutic Implicati...mentioning

confidence: 99%

Toad venom-derived bufadienolides and their therapeutic application in prostate cancers: Current status and future directions

Zhou

Han

et al. 2023

Front. Chem.

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Cancer is the second leading cause of death worldwide. Specially, the high incidence rate and prevalence of drug resistance have rendered prostate cancer (PCa) a great threat to men’s health. Novel modalities with different structures or mechanisms are in urgent need to overcome these two challenges. Traditional Chinese medicine toad venom-derived agents (TVAs) have shown to possess versatile bioactivities in treating certain diseases including PCa. In this work, we attempted to have an overview of bufadienolides, the major bioactive components in TVAs, in the treatment of PCa in the past decade, including their derivatives developed by medicinal chemists to antagonize certain drawbacks of bufadienolides such as innate toxic effect to normal cells. Generally, bufadienolides can effectively induce apoptosis and suppress PCa cells in-vitro and in-vivo, majorly mediated by regulating certain microRNAs/long non-coding RNAs, or by modulating key pro-survival and pro-metastasis players in PCa. Importantly, critical obstacles and challenges using TVAs will be discussed and possible solutions and future perspectives will also be presented in this review. Further in-depth studies are clearly needed to decipher the mechanisms, e.g., targets and pathways, toxic effects and fully reveal their application. The information collected in this work may help evoke more effects in developing bufadienolides as therapeutic agents in PCa.

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“…Cancer is a common disease globally that seriously affects human health. Recent studies have illuminated that CBF suppressed the growth of a wide variety of tumor cells, including liver cancer, osteosarcoma, melanoma, colorectal cancer, acute promyelocytic leukemia, nasopharyngeal carcinoma, multiple myeloma, breast cancer, and gastric carcinoma [ 15 ]. The anticancer activities and related mechanisms of CBF are listed in Table 1 .…”

Section: Pharmacological Activities Of Cbfmentioning

confidence: 99%

Pharmacological Effects of Cinobufagin

2023

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Cinobufagin (CBF) is a bufadienolide, which is a major active ingredient of toad venom. In recent years, CBF has attracted increasing attention due to its highly potent and multiple pharmacological activities. To better understand the status of research on CBF, we collated recent studies on CBF to provide a valuable reference for clinical researchers and practitioners. According to reports, CBF exhibits extensive pharmacological properties, including antitumor, analgesic, cardioprotection, immunomodulatory, antifibrotic, antiviral, and antiprotozoal effects. Studies on the pharmacological activity of CBF have mainly focused on its anticancer activity. It has been demonstrated that CBF has a therapeutic effect on liver cancer, osteosarcoma, melanoma, colorectal cancer, acute promyelocytic leukemia, nasopharyngeal carcinoma, multiple myeloma, gastric cancer, and breast cancer. However, the direct molecular targets of CBF are currently unknown. In addition, there are few reports on toxicological and pharmacokinetic of CBF. Subsequent studies focusing on these aspects will help promote the development and application of CBF in clinical practice.

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A research update on the antitumor effects of active components of Chinese medicine ChanSu

Cited by 24 publications

References 129 publications

Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives

Animal-derived natural products for hepatocellular carcinoma therapy: current evidence and future perspectives

Toad venom-derived bufadienolides and their therapeutic application in prostate cancers: Current status and future directions

Pharmacological Effects of Cinobufagin

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