A restricted cell population propagates glioblastoma growth after chemotherapy

Chen, Jian; Li, Yanjiao; Yu, Tzong-Shiue; McKay, Renée M.; Burns, Dennis K.; Kernie, Steven G.; Parada, Luis F.

doi:10.1038/nature11287

Cited by 2,012 publications

(1,791 citation statements)

References 19 publications

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“…The prognosis of astrocytoma differs according to features such as age, disease stage, and histological type. GBM is the most malignant astrocytoma, with a median overall survival (OS) of approximately 12 months and a 5‐year OS of 4.8%‐5.4%,1, 2, 3 while patients suffering from anaplastic astrocytoma have a median OS of 38 months and a 5‐year OS of 25.9%‐41.1% 1, 4. A deeper understanding of the prognostic factors of GBM may provide new ideas for the prevention and management of this disease.…”

Section: Introductionmentioning

confidence: 99%

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

et al. 2018

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The relationship between marital status and glioblastoma multiforme (GBM) has not been addressed in depth. Here, we aimed to investigate the association between marital status and survival in GBM. We searched the Surveillance, Epidemiology, and End Results (SEER) database and extracted the data of eligible patients diagnosed with GBM after 2004. Marital status was classified as married, divorced/separated, widowed, and single. A Kaplan‐Meier test was conducted to compare the survival curves of different groups. Multivariate Cox regression was performed to evaluate overall survival (OS) and cause‐specific survival (CSS) in different groups. Subgroup analysis was applied according to demographics, typical education and income levels in the locale, and insurance status. A total of 30 767 eligible patients were included. The median OS values were 9, 7, 3, 9 months in married, divorced/separated, widowed, and single patients, respectively. After adjustment for other covariates, married patients had better OS and CSS than other patients had. In addition to marital status, demographic factors, disease progression factors, local educational level, and insurance status were also associated with survival in GBM. Furthermore, subgroup analyses revealed the protective effect of marriage in most of the comparisons. Notably, the protective effect of marriage becomes more and more apparent as time goes on. The advantageous effect of marriage on GBM survival is especially prominent in patients who are male, older than 60 years of age, White, or living in middle‐income counties. In conclusion, marital status is an independent prognostic factor for GBM.

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Section: Introductionmentioning

confidence: 99%

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

et al. 2018

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“…A minor cell population, constituted of multipotent tumor-initiating stem-like cells (GSCs), has been recently implicated in GBM recurrence and resistance to conventional treatments [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

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Kumar

et al. 2016

Journal of Controlled Release

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Release, 238 . pp. 43 57. ISSN 0168 3659 It is advisable to refer to the publisher's version if you intend to cite from the work.http://dx.doi.org/10. 1016/j.jconrel.2016.07.032 For more information about UCLan's research in this area go to http://www.uclan.ac.uk/researchgroups/ and search for . This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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“…These confusing data are particularly troublesome in the case of the esophagus and the common premalignant lesion Barrett's Esophagus (BE). First there have been reports of fast cycling cells with stem cell capacity in animal models and some of them indicate a residual stem cell population is needed while others do not [11][12][13][14][15] . Second some additional reports have implicated endodermal (including epithelial) embryonic markers in man but their relevance to human stem cells remains unclear 16 .…”

Section: Introductionmentioning

confidence: 99%

Identification of Lineage-Uncommitted, Long-Lived, Label-Retaining Cells in Healthy Human Esophagus and Stomach, and in Metaplastic Esophagus

et al. 2013

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Background & Aims:The existence of slowly-cycling, adult stem cells has been challenged by the identification of actively cycling cells. We investigated the existence of uncommitted, slowly cycling cells by tracking 5-iodo-2'-deoxyuridine (IdU) label-retaining cells (LRCs) in normal esophagus, Barrett's esophagus (BE), esophageal dysplasia, adenocarcinoma, and healthy stomach tissues from patients.Methods: Four patients (3 undergoing esophagectomy, 1 undergoing esophageal endoscopic mucosal resection for dysplasia and an esophagectomy for esophageal adenocarcinoma) received intravenous infusion of IdU (200 mg per m 2 body surface area, maximum dose of 400 mg) over a 30-min period; the IdU had a circulation t 1/2 of 8hs. Tissues were collected at 7, 11, 29 and 67 days following infusion, from regions of healthy esophagus, BE, dysplasia, adenocarcinoma, and healthy stomach; they were analyzed by in situ hybridization, flow cytometry, and immunohistochemical analyses. Results:No LRCs were found in dysplasias or adenocarcinomas, but there were significant numbers of LRCs in the base of glands from BE tissue, in the papillae of the basal layer of the esophageal squamous epithelium, and in the neck/isthmus region of healthy stomach. These cells cycled slowly, because IdU was retained for at least 67 days and co-labeling with Ki-67 was infrequent. In glands from BE tissues, most cells did not express defensin-5, Muc-2, or chromogranin A, indicating that they were not lineage committed. Some cells labeled for endocrine markers and IdU at 67 days; these cells represented a small population (<0.1%) of epithelial cells at this timepoint. The epithelial turnover time of the healthy esophageal mucosa was approximately 11 days (twice that of the intestine). Conclusions:LRCs of human esophagus and stomach have many features of stem cells (long lived, slow cycling, uncommitted, and multipotent), and can be found in a recognized stem cell niche. Further analyses of these cells, in healthy and metaplastic epithelia is required.4

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A restricted cell population propagates glioblastoma growth after chemotherapy

Cited by 2,012 publications

References 19 publications

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

Effect of marital status on survival in glioblastoma multiforme by demographics, education, economic factors, and insurance status

A combined microRNA-based targeted therapeutic approach to eradicate glioblastoma stem-like cells

Identification of Lineage-Uncommitted, Long-Lived, Label-Retaining Cells in Healthy Human Esophagus and Stomach, and in Metaplastic Esophagus

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