A Retrospective analysis on Oral Squamous Cell Carcinoma Patients Indicated for Chemotherapy

Abstract

Neo adjuvant chemotherapy has been studied in oral cavity with the aim of improving locoregional control and overall survival rates as an organ preservation tool in the resettable cancers. It is usually given post operative to improve the quality of life and to increase the survival rates. This study was conducted by reviewing the records of patients visiting the Oral Oncology department in Saveetha Dental College and hospitals, between 1 st June 2019 -1 st April 2020. Among 57 carcinoma patients (maxillary, mandibular, buccal carcinoma) 16 (28%) patients were treated with the chemotherapy post operatively. There was male predominance with 9 males (57%) and 7 females (43%) in this study. The mean age of the patient's undergoing chemotherapy was 40-50 years, ranging from 20 to 60 years of age. Among various sites of carcinoma patients subjected to chemotherapy, maxillary carcinoma accounted to 8 patients (50%) mandibular carcinoma-5 patients (31.25%), buccal mucosa carcinoma-3 patients (18.75%) Chi-square test was done on association between gender and number of patients with carcinoma in different sites and found not statistically significant [chi square value-0.2320, p value-0.314 (p>0.05)]. Chi-square test was done to find the association between age and type of carcinoma and was found to be statistically not significant [chi square value-0.529, p value-0.612(p>0.05)]. From this study we can conclude that chemotherapy treatment was commonly undergone by men and patients in the 4th decade of life. Maxillary carcinoma patients underwent chemotherapy more commonly as compared to mandibular carcinoma patients or buccal carcinoma patients. Association between age and incidence of chemotherapy treatment, gender and incidence of chemotherapy treatment was found statistically not significant.