A retrospective analysis: seasonal decline in implantation rates (IR) and its correlation with increased levels of volatile organic compounds (VOC)

Worrilow, Kathryn C.; Huynh, H.T.; Bower, J.B.; Schillings, Wendy; Peters, Albert J.

doi:10.1016/s0015-0282(02)03482-9

Cited by 24 publications

(15 citation statements)

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“…Due to the poor air quality, high VOC levels, and the hot and humid weather in Guangzhou, the filters may became saturated earlier than anticipated, and thereby certain VOCs may not be removed. We hypothesize that the summertime seasonal elevations in temperature and humidity may also initiate the desorption of trapped VOCs from the carbon filters installed in the laboratory air handling system, and reduce the adsorption efficacy of the system [25]. …”

Section: Discussionmentioning

confidence: 99%

Better IVF outcomes following improvements in laboratory air quality

Khoudja

et al. 2012

J Assist Reprod Genet

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BackgroundIt has been proved that air quality is crucial for the success of IVF because of the presence of volatile organic compounds (VOCs), microbes, and perfumes, all of which can be harmful to embryo development in vitro. Therefore IVF laboratories are equipped with high efficiency particulate air (HEPA), and activated carbon filters plus positive pressure for air particulate control, with or without CODA system. Here we introduce a new technology using specially treated Honeycomb matrix media aligned in the Landson ™ series system for our laboratory air purification and its impact on IVF outcome.MethodsAir samples were collected outside and inside the laboratory, and intra-incubator at three different time points, before and after changing carbon filters and after Landson system installation, and we correlated air compounds measure variation with IVF outcome from 1403 cycles.ResultsAn improvement of air quality was confirmed with passages of total VOCs from 0.42 mg/m3, 30.48 mg/m3, 9.62 mg/m3, to 0.1 mg/m3, 2.5 mg/m3, 2.19 mg/m3 through 0.07 mg/m3, 0.16 mg/m3, 0.29 mg/m3, outside the laboratory, inside laboratory and intra-incubator respectively at three separated air sampling times. A clear decrease was observed in some VOCs such as formaldehyde, ethylene, acethylene, propylene, SO2, pentane, NOx, benzene, Hallon-1211, CFC and alcohol.At the same time a significant difference (P < 0.05) was found between the third testing time TT3 after carbon filter change and Landson system installation and the first testing time TT1 before carbon filter change in fertilization rate 83.7 % vs 70.1 %, embryo cleavage rate 97.35 % vs 90.8 %, day 5 blastocyst formation rate 51.1 % vs 41.7 %, and pregnancy/implantation rates 54.6 %, 34.4 % vs 40.6 %, 26.4 %.ConclusionAir purification by the new technology of Landson ™ series significantly improved IVF laboratory air quality, and embryo quality, thus increased pregnancy and implantation rates.

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Section: Discussionmentioning

confidence: 99%

Better IVF outcomes following improvements in laboratory air quality

Khoudja

et al. 2012

J Assist Reprod Genet

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“…On being a very specific and delicate application, it is impossible to reach any categorical or overall conclusions as regards their incidence on embryos, particularly when taking into account the high toxicity of acrolein and its effect on the molecular mechanisms of cellular replication (Hall et al, 1998). Certain COVs can be absorbed by culture media (isopropanol) (Cohen et al, 1997) and even affect the implantation rate (Worrilow et al, 2002). In any case, it would be necessary to conduct a viability study on samples at different concentrations and exposure results, with the controversy that this would provoke.…”

Section: Discussionmentioning

confidence: 99%

The design of an in vitro fertilization (IVF) laboratory and its importance in risk prevention: applicability of UV radiation

Gea-Izquierdo¹,

Velasco

Escudero

et al. 2009

Braz. arch. biol. technol.

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This study addressed the environmental control of an IVF laboratory and the potential repercussions that the presence of certain physical, chemical and biological agents could have on workers' health or on the tasks they carried out. The design of the laboratory and its facilities contributed to an improvement in work qualityand minimised the environmental-related risks. The preventive measures adopted had an influence on the carried out actions.

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“…The research highlighted the significant contribution made by patients, healthcare workers, and various clinical processes [20]. External environmental events, even those outside of the immediate proximity of a clinical space, were also found to greatly impact positive outcomes [21][22][23][24][25][26][27][28]. By removing airborne chemical and biological pathogens to below-detection levels, the LAS-APS provides unprecedented control over air quality and significant positive impact on clinical outcomes [25][26][27][28].…”

Section: Genesis Of Las-aps Air Filtration Paradigmmentioning

confidence: 94%

Comprehensive and Live Air Purification as a Key Environmental, Clinical, and Patient Safety Factor: A Prospective Evaluation

Stawicki¹,

Brisendine²,

Levicoff³

et al. 2019

Vignettes in Patient Safety - Volume 4 [Working Title]

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Healthcare organizations strive to provide optimal patient experience by improving care quality and enhancing clinical outcomes, while containing associated costs. In the United States, the Center for Disease Control (CDC) estimates that more than 1.7 million people suffer from an infectious complication annually, representing between 5 and 10% of all hospital admissions and costs ranging between $35B and $88B. Most infectious surface fomites originate from air. Consequently, reducing airborne pathogens should be associated with reduced surface fomites. This study represents the first comprehensive evaluation of infectious and aerosolized pathogens and their speciation, location and concentration within a typical hospital setting. The study provides data regarding the relationship between airborne pathogens and air filtration methodologies in the context of the molecular and microbial epidemiology of illness and infections in the clinical setting. The results demonstrated that using a transformational air purification system provided comprehensive remediation of airborne pathogens and significantly reduced surface-oriented infectious fomites. Overall reduction of airborne and surface bacterial and fungal pathogens responsible for illness and infections will result in a reduction of associated illnesses and HAI rates and improved patient care metrics including stay duration and readmission rates. Improvements in these outcome metrics should correlate to risk mitigation and cost avoidance.

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A retrospective analysis: seasonal decline in implantation rates (IR) and its correlation with increased levels of volatile organic compounds (VOC)

Cited by 24 publications

References 0 publications

Better IVF outcomes following improvements in laboratory air quality

Better IVF outcomes following improvements in laboratory air quality

The design of an in vitro fertilization (IVF) laboratory and its importance in risk prevention: applicability of UV radiation

Comprehensive and Live Air Purification as a Key Environmental, Clinical, and Patient Safety Factor: A Prospective Evaluation

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