A retrospective case study of clinical profile of hospitalized children with type 1 diabetes mellitus at a tertiary health care center in northern India

Prasad, Durga; Arpita,; Awasthi, Sanjay

doi:10.1016/j.cegh.2013.02.002

Cited by 9 publications

(19 citation statements)

References 7 publications

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“…6 The mean age at presentation in our series was 7.96 year+ 3.63. This is in agreement with other studies from India, that by Durga Prasad et al 7 (mean age + SD 8.12 + 3.7). In the current study, it was observed that majority of the study population (71.76%) were above 5 years of age and only 28.24% in 0-5 years age group.…”

Section: Discussionsupporting

confidence: 94%

Clinico-Laboratory Characteristics and Immediate Outcome in Children With Diabetes Mellitus

Padma¹,

Krishnan²

2019

jemds

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BACKGROUND Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycaemia resulting from an absolute or relative deficiency of insulin. The burden of childhood diabetes is rising all over the world. METHODS This is a descriptive study conducted at a tertiary care hospital. Eighty-five children with diabetes mellitus admitted during the study period were included. Clinical details, laboratory parameters were collected from the medical records and the data was analysed using statistical tests. RESULTS Eighty-five children less than 12 years were included in this study. Female: male ratio was 1.43:1. Age wise distribution was 0-5 years (28.24%), 5-10 years (40%), 10-12 years (31.76%). Majority of them were from lower socioeconomic class (71.76%). Family history of diabetes mellitus was present in forty-one children. Majority of them presented with osmotic symptoms like polyuria (82.35%), polydipsia (80%). Forty-six children presented with diabetic ketoacidosis. Type 1 diabetes was diagnosed in 88.24% of the subjects. There were two children with Type 2 diabetes mellitus. The mean RBS at presentation was 470.42±125.02 and the mean HbA1c was 11.05 ± 1.98. There was no statistically significant difference in the duration of onset of symptoms to diagnosis between the ketotic and non ketotic group. The BMI was in the range 10 to 25, with mean value 15.09 ± 3.39. There was no mortality among the subjects. CONCLUSIONS Type 1 diabetes is still the predominant form of diabetes among children. Osmotic symptoms like polyuria, polydipsia are the most common presenting symptoms. Younger children are more prone to have diabetic ketoacidosis. Awareness of diabetes care is essential for the successful management of the disease.

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Section: Discussionsupporting

confidence: 94%

Clinico-Laboratory Characteristics and Immediate Outcome in Children With Diabetes Mellitus

Padma¹,

Krishnan²

2019

jemds

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“…8 Other research conducted at King George's Medical University Hospital, India showed that pediatric patients with type 1 diabetes mellitus who suffered from diabetic ketoacidosis, commonly suffered from hyponatremia. 9 However, in this study, hypernatremia patients were dominated by a diagnosis of acute diarrhea severe dehydration. These results are different from research conducted at M. Djamil Academic Hospital Padang, acute diarrhea with severe dehydration in pediatric patients showed that the most electrolyte disorders experienced was hyponatremia.…”

Section: Demographic Profile Of Patientsmentioning

confidence: 58%

Electrolytes Profile of Critically Ill Patients Admitted To Pediatric Intensive Care Unit (PICU) Dr. Soetomo General Hospital

Octavia

Setyaningtyas

Edwar

2020

IJAR

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Introduction: Fluid and electrolyte disorders can be affected by various conditions or diseases. Electrolyte disorders are often found in pediatric patients with critically ill conditions and are associated with increased morbidity also mortality that requires extra care in the Pediatric Intensive Care Unit (PICU). Objective: To describe the electrolyte profile of critically ill patients with electrolyte disorders admitted to the Pediatric Intensive Care Unit (PICU) Dr. Soetomo General Hospital. Materials and Methods: The study was conducted prospectively with a descriptive method in patients with electrolyte disorders aged 1 month -18 years old admitted to PICU Dr. Soetomo General Hospital, Surabaya in a period from August to November 2018. Data on patient age, gender, electrolyte profile (sodium, potassium, calcium, chloride), and origin before PICU admission were recorded. Results and Discussion: From 37 patients with electrolyte disorders showed that patients were dominated by the male in 56.8% (n=21), in the age group of infants or 1-12 months old in 45.9% (n=17). Common main diagnosis in most patients were digestive system disorders in 27% (n=10), followed by central nervous system, respiratory system, kidney and cardiovascular disorders, and the origin before PICU admission were from Emergency Room (ER) in 62.2% (n=23). There were found 97 incidences of electrolyte disorders. Most frequent electrolyte disorders were hypocalcemia in 59.5% (n=22), hypokalemia in 54.1% (n=20), hyponatremia in 40.5% (n=15) and the least was hypochloremia in 35.1% (n=13). Mean serum sodium level was 138.18 ± 12.071, serum potassium level was 3.608 ± 1.2247, serum calcium level was 8.057 ± 1.9473 and serum chloride level was 101.45 ± 13.266. Conclusions: Critically ill patients admitted in PICU tend to experience low electrolyte levels. ABSTRAK Pendahuluan: Gangguan cairan dan elektrolit dapat dipengaruhi oleh berbagai kondisi atau penyakit. Gangguan elektrolit sering ditemukan pada pasien anak dengan kondisi sakit kritis dan dikaitkan dengan peningkatan morbiditas serta mortalitas yang memerlukan perawatan ekstra di Pediatric Intensive Care Unit (PICU). Tujuan: Untuk menggambarkan profil elektrolit pada pasien sakit kritis yang dirawat di PICU RSUD Dr. Soetomo, Surabaya. Metode dan Bahan: Penelitian ini dilakukan secara prospektif dengan metode deskriptif pada pasien dengan gangguan elektrolit berusia 1 bulan -18 tahun yang dirawat di PICU Rumah Sakit Umum Daerah (RSUD) Dr. Soetomo, Surabaya dalam periode dari bulan Agustus 2018 hingga November 2018. Data berupa usia, jenis kelamin, profil elektrolit serum (natrium, kalium, kalsium, klorida), dan asal pasien dicatat. Hasil dan Pembahasan: Dari 37 pasien, menunjukkan bahwa pasien didominasi oleh laki-laki sebesar 56,8% (n = 21), pada kelompok usia bayi atau usia 1-12 bulan sebesar 45,9% (n = 17). Diagnosis utama terbanyak pada pasien adalah gangguan sistem pencernaan sebesar 27% (n = 10), diikuti oleh gangguan sistem saraf, pernapasan, ginjal, dan sistem kardiovaskular. Asal pas...

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“…In contrast to this, other studies showed a slightly upward trend in the severity of DKA. 15,[18][19][20] Data from our study has shown that there is no significant association between the severity of ketoacidosis and the demographic variables like age, gender, socioeconomic status and family history of diabetes. This is supported by report from other studies.…”

Section: Graph 1 Profile Of Symptomsmentioning

confidence: 91%

Diabetic Ketoacidosis in Children- Clinical Profile and Outcome

Padma¹,

Antony²

2017

jebmh

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BACKGROUND Diabetic ketoacidosis is a potentially life-threatening condition, which accounts for the majority of diabetes-related morbidity and mortality in children with type 1 diabetes mellitus. Early diagnosis and prompt management substantially reduces the mortality. The aim of the study is to assess the clinical characteristics and early outcome in children with diabetic ketoacidosis. MATERIALS AND METHODS This is a descriptive study done in a tertiary care hospital. Fifty two episodes of diabetic ketoacidosis in children of age ≤12 years admitted during the period 2011 to 2016 were included in the study. Clinical details, investigations and complications were recorded in a pro forma and data was analysed using statistical tests. RESULTS Fifty two episodes of diabetic ketoacidosis were included in the study. Thirty three (63.5%) children presented with DKA at first diagnosis of diabetes, whereas 19 (36.5%) were DKA among children with established diabetes. Mean age at presentation was 9.048 ± 3.24. Female-to-male ratio was (1.36:1). The mean duration of onset of symptom before hospitalisation was 10.10 ± 9.52. Most commonly observed presenting symptoms were polyuria (63.46%), polydipsia (65.38%), tiredness (61.54%), vomiting (36.54%) and pain abdomen (32.69%). Mild DKA occurred frequently than moderate and severe forms. Among these children, 40.4% had infection as the predisposing factor. Demographic variables like age, gender, socioeconomic status, family history of diabetes did not have any significant association with the severity of DKA. The clinical parameters like tachypnoea, Kussmaul breathing, shock, altered sensorium at presentation and dehydration had significant association with the severity of DKA. Similarly, hypoglycaemia, hypokalaemia, hyponatraemia, acute kidney injury and cerebral oedema had significant association with the severity of DKA. All the patients recovered with therapy. No mortality was reported. CONCLUSION Diabetic ketoacidosis can be the initial presentation of diabetes mellitus or can occur in children with established diabetes mellitus. The mortality can be reduced by timely diagnosis and proper management. Diabetes education programs and follow up care of the patients should be strengthened to reduce the incidence of DKA.

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A retrospective case study of clinical profile of hospitalized children with type 1 diabetes mellitus at a tertiary health care center in northern India

Cited by 9 publications

References 7 publications

Clinico-Laboratory Characteristics and Immediate Outcome in Children With Diabetes Mellitus

Clinico-Laboratory Characteristics and Immediate Outcome in Children With Diabetes Mellitus

Electrolytes Profile of Critically Ill Patients Admitted To Pediatric Intensive Care Unit (PICU) Dr. Soetomo General Hospital

Diabetic Ketoacidosis in Children- Clinical Profile and Outcome

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