A retrospective drug utilization evaluation of vancomycin usage in paediatric patients

Hing, Wee Chuan; Bek, Schin; Lin, Raymond Tzer‐Pin; Li, Shu Chuen

doi:10.1111/j.1365-2710.2004.00571.x

Cited by 10 publications

(10 citation statements)

References 27 publications

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“…Although vancomycin is one of the commonly used medications in critically ill pediatric patients (5), there are no benchmark criteria for vancomycin utilization in pediatric patients. Most of the reports on vancomycin use are confined to appropriateness of vancomycin prescription (12)(13)(14), indications (15), and percent of population (5, 16) who received vancomycin. Vancomycin use density per unit patient days has not been systematically studied.…”

Section: Discussionmentioning

confidence: 98%

Drug use density in critically ill children and newborns: Analysis of various methodologies

Valcourt

Norozian²,

Lee³

et al. 2009

Pediatric Critical Care Medicine

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In critically ill children, drug use density of vancomycin is significantly less when evaluated by the DDD method compared with the prescribed daily dose method, a more appropriate method in children. However, the simplest and most accurate method of assessing drug use density is the number of days of drug use method, which allows comparison of drug use density between different pediatric facilities or clinical units.

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Section: Discussionmentioning

confidence: 98%

Drug use density in critically ill children and newborns: Analysis of various methodologies

Valcourt

Norozian²,

Lee³

et al. 2009

Pediatric Critical Care Medicine

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“…It should be noted that many of the neutropenia-type reactions in patients studied in this research were excluded as ADRs because patients were also using antineoplastic drugs that may more frequently lead to the development of this ADR [8], however case reports have increased [3,7] and greater attention has been given to this ADR. In a retrospective study with pediatric patients [25], thrombocytopenia corresponded to 26.3% of ADRs, and was the second most prevalent ADR to vancomycin in that study. More recently, the incidence of this ADR was studied by monitoring patients treated with vancomycin over a five year period and this corroborated the results reported in the present study [26].…”

Section: Resultsmentioning

confidence: 97%

The study of vancomycin use and its adverse reactions associated to patients of a brazilian university hospital

Marinho

Huf

Ferreira³

et al. 2011

BMC Res Notes

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BackgroundVancomycin is an antibiotic of growing importance in the treatment of hospital infections, with particular emphasis on its value in the fight against methicillin-resistant Staphylococcus aureus. However its usage profile must be evaluated to assure maximum benefit and minimum risk.FindingsA cross-sectional retrospective study was carried out among inpatients that received vancomycin in a Brazilian quaternary hospital. The occurrence of adverse reactions reported was evaluated in medical records relating to patients taking vancomycin during a one year period. Males comprised 52% (95% CI: 41.7-60.2%) of the sample population, with a mean age of 50.6 (95% CI: 47.2-54.0) years and mean treatment period of 9.7 (95% CI: 8.0-11.5) Days. It was verified that nephrotoxicity occurred in 18.4% (95% CI: 11.3-27.5) of patients, Red man syndrome occurred in 2% (95% CI 0.2-7.2), while the occurrence of thrombocytopenia was 7.1% (95% CI: 2.9-14.2).ConclusionsIt may be noted that even after 50 years of use, adverse reactions associated with vancomycin continue with high frequency, presenting a public health problem, especially considering its current use in cases of multidrug resistant infections. In this context, we emphasize the importance of intensive pharmacovigilance in hospital as a surveillance tool after drug approval by the sanitary authority.

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“…This is higher than Retrospective drug utilization evaluation in pediatric patients in USA showed that large percentages (30%-50%) of antibiotics administered in the USA are given to prevent infection rather than to treat established disease. This practice accounts for some of the most fragment misuses of these drugs [20]. This could be due to difference in advancement in health service delivery system like advanced laboratories for diagnosis of definitive pathogens to target and expertise on antibiotics like infectious disease specialists which are at very young stage in study area.…”

Section: Discussionmentioning

confidence: 99%

“…Most frequently prescribed antibiotics to children were Ampicillin, Chloramphenicol and Gentamicin [19]. Retrospective drug utilization evaluation in pediatric patients in USA showed that large percentages (30%-50%) of antibiotics administered in the USA are given to prevent infection rather than to treat established disease [20].…”

Section: Introductionmentioning

confidence: 99%

Retrospective Drug Use pattern of Antibiotics in Pediatric Ward of Shenan Gibe Hospital, Oromia Region, Ethiopia

Achalu¹,

Mensa²

2017

JOURNAL OF ANTIBIOTICS RESEARCH

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Background: Antibiotics are one of the most widely used groups of drugs. The development of antimicrobial drugs represents one of the most important advances in therapeutics. Irrational and uncontrolled use of these agents both in developing and developed countries has resulted in an evolution of resistant strains in addition to poor health outcome. Despite this fact antimicrobial agents are vastly over prescribed in inpatient setting and the availability of antimicrobial agents without prescription in many developing countries. The use antimicrobial agents in Infants and children have become a routine practice for the treatment of pediatric illness and it needs study to show the status and pattern of antimicrobial in this age group is critical hence they are most vulnerable population groups to counteract illness. AbstractObjective: To assess the pattern of antibiotics use among hospitalized Pediatric patients in pediatric ward of Shenen Gibe Hospital, May 2015. Methods:A retrospective cross-sectional study design was used to collect data from patient medical history records from previous one year data and Data was collected by using pre-tested structured tool which is adapted from review of different literatures.Result: Three hundred twenty three pediatrics medical history cards with antibiotics were reviewed in this study. Majority of participants 188(58.2%) were males and 197(61%) and belongs to age group 0-4 years with mean age of 3.5 years. Regarding duration of hospitalization for 200 (61.9%) was 5 to 9 days with median duration of 5.7 days. Majority of patients 251(77.7%) were treated empirically. Pneumonia was single most common reason for hospitalization which accounts 125 (38.7%) followed by Sepsis 49 (15.2%) and acute gastro enteritis 41(12.7%). The most commonly used antibiotic combinations were Ceftriaxone + Gentamicin 97(32.8%). Antibiotics were prescribed with correct dose for 294(91%) and correct frequency for 280(86.7%) and 316(97.6%) were treated with injections.

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A retrospective drug utilization evaluation of vancomycin usage in paediatric patients

Cited by 10 publications

References 27 publications

Drug use density in critically ill children and newborns: Analysis of various methodologies

Drug use density in critically ill children and newborns: Analysis of various methodologies

The study of vancomycin use and its adverse reactions associated to patients of a brazilian university hospital

Retrospective Drug Use pattern of Antibiotics in Pediatric Ward of Shenan Gibe Hospital, Oromia Region, Ethiopia

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