A retrospective observational study to see the effect of dual trigger on IVF outcomes in poor ovarian responders

Abstract

Background: Poor Responders Patients undergoing IVF treatment were given Dual Trigger for final oocyte maturation. Poor responders are the patients in whom, less number of egg were retrieved. Typically, they were with advanced maternal age and poor ovarian reserve (AFC <5-7 follicle or AMH < 1.2ng/ml) or with a history of previous Poor ovarian reserve (<3 oocytes) with Controlled ovarian stimulation. This study aimed to examine the effectiveness of dual trigger for final oocyte maturation in poor responder patients based on Bologna criteria (2011). Methods: A total of 30 IVF cycles of poor responder patients were retrospectively analyzed. The study group (15 patients) was given dual triggers (HCG and GnRH agonist) for final oocyte maturation whereas in control group final oocyte maturation was performed with HCG only. GnRH antagonist Protocol was used in both the groups. Baseline characteristics, number of oocyte retrieved, the number of M-2 and the quality of embryo of both groups were compared. Results: Both the groups were comparable in baseline characteristics. In our study, there was not much difference in number of oocyte retrieved, but there was higher number of M2 and top quality embryo, compared to control group. Conclusion: Dual trigger might be a superior option for final oocyte maturation as compared to hCG trigger alone in terms of IVF cycles outcomes in poor responders and further large scale randomized prospective studies needed to validate our results.