A retrospective study comparing D1 limited lymph node dissection and D2 extended lymph node dissection for N3 gastric cancer

Luo, Xiaoning; Zhou, Miaofang; Wei, Tian; Zeng, Ming; Xia, Jianbo; Zhao, Gao-ping; Hu, Honglin; Hao, Xinbao; Han, Liang; Líu, Hao; He, Yi; Zhu, Xiaopeng; Liang, Liang; Wei, Min; Deng, Lili

doi:10.21037/tcr.2020.03.42

Cited by 2 publications

(3 citation statements)

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“…The primary aim of D2 lymphadenectomy is to eliminate an extended spectrum of potentially affected lymph nodes and reduce the chance of residual tumor burden. 1 provides a concise summary of the key characteristics and differences between D1 and D2 lymphadenectomy approaches in terms of the extent of lymph node dissection, number of retrieved lymph nodes, operative time, and postoperative complications) [51][52][53][54][55][56][57][58]. (Table 2 provides a general overview of the short-term outcomes, but it is important to note that these ranges may vary depending on several factors, such as the patient's overall health, tumor stage, and surgical skill.…”

Section: The Effectiveness Of D1 Lymphadenectomy Compared To D2 Lymph...mentioning

confidence: 99%

“… ( Table 1 provides a concise summary of the key characteristics and differences between D1 and D2 lymphadenectomy approaches in terms of the extent of lymph node dissection, number of retrieved lymph nodes, operative time, and postoperative complications) [ 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. …”

Section: Tablementioning

confidence: 99%

“…Comparison of D1 and D2 lymphadenectomy approaches in advanced gastric cancer[51][52][53][54][55][56][57][58].…”

mentioning

confidence: 99%

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Uncovering the Impact of Lymphadenectomy in Advanced Gastric Cancer: A Comprehensive Review

Dinescu,

Gheorman,

Georgescu

et al. 2023

Life

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Gastric cancer is a significant health concern worldwide, and lymphadenectomy plays a crucial role in its treatment. However, there is ongoing debate regarding the optimal approach—D1 or D2 lymphadenectomy. This paper aims to synthesize the available evidence by conducting a comprehensive literature review and comparing the advantages and disadvantages of both techniques. The analysis includes studies, clinical trials, and systematic reviews that assess survival outcomes, morbidity, and quality of life. The selected studies revealed different outcomes associated with D1 and D2 lymphadenectomy, including lymph node harvest, disease control, recurrence rates, and overall survival. Postoperative complications also varied between the two techniques. These findings highlight the complex considerations involved in selecting the most suitable lymphadenectomy approach for individual patients. Therefore, the decision requires an individualized assessment that considers the potential benefits and risks of D1 and D2 techniques. A collaborative approach involving interdisciplinary teams is crucial for developing personalized treatment plans that optimize both oncological outcomes and postoperative quality of life.

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Section: The Effectiveness Of D1 Lymphadenectomy Compared To D2 Lymph...mentioning

confidence: 99%

Section: Tablementioning

confidence: 99%

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Uncovering the Impact of Lymphadenectomy in Advanced Gastric Cancer: A Comprehensive Review

Dinescu,

Gheorman,

Georgescu

et al. 2023

Life

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Lymph Node Dissection of Choice in Older Adult Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

Ramírez-Giraldo,

Avendaño-Morales,

Van-Londoño

et al. 2024

JCM

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Background: Although the current literature has shown an increasing interest in surgical treatment of gastric cancer (GC) in older adults in recent years, there is still no consensus on proper management in this subgroup of patients. This study was designed with the objective of evaluating the current evidence that compares limited lymph node dissection with extended lymph node dissection in older adult patients (≥65 years) coursing with resectable GC. Methods: A systematic review of PubMed, Cochrane library, and ScienceDirect was performed according to PRISMA guidelines. All studies before 2018 were selected using a systematic review by Mogal et al. Studies were eligible for this meta-analysis if they were randomized controlled trials or non-randomized comparative studies comparing limited lymph node dissection versus extended lymph node dissection in patients with resectable GC taken to gastrectomy. Results: Seventeen studies and a total of 5056 patients were included. There were not any statistically significant differences in OS (HR = 1.04, CI95% = 0.72–1.51), RFS (HR = 0.92, CI95% = 0.62–1.38), or CSS (HR = 1.24, CI95% = 0.74–2.10) between older adult patients taken to limited and extended lymphadenectomy in addition to gastrectomy as the current surgical treatment for GC. Although a higher rate of major complications was observed in the extended lymphadenectomy group, this difference was not statistically significant in incidence between both groups of patients (OR = 1.92, CI95% = 0.75–4.91). Conclusions: Limited lymphadenectomy must be considered as the better recommendation for surgical treatment for GC in older adult patients, considering the oncological outcomes and lower rates of complications compared with more radical lymph node dissections.

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A retrospective study comparing D1 limited lymph node dissection and D2 extended lymph node dissection for N3 gastric cancer

Cited by 2 publications

References 23 publications

Uncovering the Impact of Lymphadenectomy in Advanced Gastric Cancer: A Comprehensive Review

Uncovering the Impact of Lymphadenectomy in Advanced Gastric Cancer: A Comprehensive Review

Lymph Node Dissection of Choice in Older Adult Patients with Gastric Cancer: A Systematic Review and Meta-Analysis

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