A retrospective study :myelodysplastic syndrome with t(9;22)(q34; q11)/BCR-ABL1 predicts a poor prognosis

Abstract

This study further verified this conclusion by reviewing and comparing prognostic and clinical features of 69 cases with MDS with and without the Ph chromosome. Our research shows that MDS with Ph chromosomes had high white blood cell (WBC) counts (P = 0.007), and both overall survival (OS) and leukemia-free survival (LFS) are short, especially in MDS Ph with additional abnormalities, and Ph chromosome aberration was an independent risk factor for OS and LFS in MDS patients. Importantly, we observed that the Revision of the International Prognostic Scoring System scores (IPSS-R) in the isolated Ph group was significantly lower than that in the abnormal chromosome without Ph group, but OS in the abnormal chromosome without Ph group was longer than that in the isolated Ph group, so Ph chromosome aberration may be an important predictor of poor prognosis in MDS patients, and if it can be included in IPSS-R, it will be a supplement to the current scoring criteria. This study suggests that patients with the Ph chromosome have a high WBC count, a poor prognosis and a high-risk of progression to leukemia, especially those Ph with additional abnormalities. In addition, Ph chromosome may be an important Prognostic factor for poor prognosis of MDS. If it can be included in the Revised International Prognostic Scoring System in the future, it may be a further complement to the existing criteria.