A retrospective study on hypophysectomy in feline acromegaly

Coster, Chloe; Fenn, Joe; Glanemann, Barbara; Woolhead, Vanessa; Niessen, Stijn; Church, D B

doi:10.22233/9781910443774.53.2

BSAVA Congress Proceedings 2020 2020

DOI: 10.22233/9781910443774.53.2

|View full text |Cite

A retrospective study on hypophysectomy in feline acromegaly

Chloe Coster¹,

Joe Fenn²,

Barbara Glanemann³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2020

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Treatment options for feline pituitary adenoma include radiation, somatostatin analogs, dopaminergic agonists, and transsphenoidal hypophysectomy, 2,5,8,10,33,39,40,44,45 but depend on the endocrine functionality of the tumor. Hypophysectomy has the advantage of allowing antemortem histologic diagnosis.…”

mentioning

confidence: 99%

“…18,28,49 Insulin-resistant diabetes mellitus is an important and common complication of both feline hypersomatotropism and hypercortisolism. 1,4,18,35,49 Treatment options for feline pituitary adenoma include radiation, somatostatin analogs, dopaminergic agonists, and transsphenoidal hypophysectomy, 2,5,8,10,33,39,40,44,45 but depend on the endocrine functionality of the tumor. Hypophysectomy has the advantage of allowing antemortem histologic diagnosis.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Feline Pituitary Adenomas: Correlation of Histologic and Immunohistochemical Characteristics With Clinical Findings and Case Outcome

Miller

Piotrowski

Donovan³

et al. 2020

Vet Pathol

View full text Add to dashboard Cite

Pituitary glands from 141 feline autopsy cases were reviewed histologically. Adenoma and hyperplasia were the most common lesions at 13 cases each. Pituitary adenoma was more likely than hyperplasia to be associated with clinical evidence of endocrinopathy or an intracranial mass ( P < .001). A histochemical and immunohistochemical panel was applied to 44 autopsy- or hypophysectomy-derived pituitary adenomas in 43 cats from 2 diagnostic laboratories. Adenomas were differentiated from hyperplasia by the presence of disrupted reticulin fibers. One cat had a double (somatotroph and melanotroph) adenoma. Twenty somatotroph adenomas consisted of periodic acid-Schiff (PAS)-negative acidophils that expressed growth hormone; 16/20 had hypersomatotropism; 17/20 had diabetes mellitus. Eleven melanotroph adenomas consisted of PAS-positive basophils or chromophobes that expressed melanocyte-stimulating and adrenocorticotrophic hormones; 5/11 had hypercortisolism; 6/11 had diabetes mellitus. Eleven gonadotroph adenomas consisted of PAS-negative chromophobes that expressed follicle-stimulating and/or luteinizing hormones. Two thyrotroph adenomas consisted of PAS-negative basophils or chromophobes that expressed thyroid-stimulating hormone. Pituitary-dependent disease was not recognized in cats with gonadotroph or thyrotroph adenomas. The Ki-67 proliferation index in hypophysectomy specimens was lower in somatotroph than in melanotroph adenomas. Fourteen cats with hypophysectomy-treated somatotroph or melanotroph adenoma had an 899-day median survival time versus 173 days in 17 nonsurgical cases. After adjusting for age, adenoma size and type, hypophysectomized cats had an overall better survival time than nonsurgical cases ( P = .029). The study results underscore the value of hypophysectomy and trophic hormone immunohistochemistry in the treatment and classification of feline pituitary adenomas.

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

Feline Pituitary Adenomas: Correlation of Histologic and Immunohistochemical Characteristics With Clinical Findings and Case Outcome

Miller

Piotrowski

Donovan³

et al. 2020

Vet Pathol

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

A retrospective study on hypophysectomy in feline acromegaly

Cited by 1 publication

References 0 publications

Feline Pituitary Adenomas: Correlation of Histologic and Immunohistochemical Characteristics With Clinical Findings and Case Outcome

Feline Pituitary Adenomas: Correlation of Histologic and Immunohistochemical Characteristics With Clinical Findings and Case Outcome

Contact Info

Product

Resources

About