A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer

Abstract

PurposeProton therapy is sensitive to anatomical changes, often occurring in head‐and‐neck (HN) cancer patients. Although multiple studies have proposed online adaptive proton therapy (APT), there is still a concern in the radiotherapy community about the necessity of online APT. We have performed a retrospective study to investigate the potential dosimetric benefits of online APT for HN patients relative to the current offline APT.MethodsOur retrospective study has a patient cohort of 10 cases. To mimic online APT, we re‐evaluated the dose of the in‐use treatment plan on patients’ actual treatment anatomy captured by cone‐beam CT (CBCT) for each fraction and performed a templated‐based automatic replanning if needed, assuming that these were performed online before treatment delivery. Cumulative dose of the simulated online APT course was calculated and compared with that of the actual offline APT course and the designed plan dose of the initial treatment plan (referred to as nominal plan). The ProKnow scoring system was employed and adapted for our study to quantify the actual quality of both courses against our planning goals.ResultsThe average score of the nominal plans over the 10 cases is 41.0, while those of the actual offline APT course and our simulated online course is 25.8 and 37.5, respectively. Compared to the offline APT course, our online course improved dose quality for all cases, with the score improvement ranging from 0.4 to 26.9 and an average improvement of 11.7.ConclusionThe results of our retrospective study have demonstrated that online APT can better address anatomical changes for HN cancer patients than the current offline replanning practice. The advanced artificial intelligence based automatic replanning technology presents a promising avenue for extending potential benefits of online APT.

Multi-institutional experimental validation of online adaptive proton therapy workflows

“…Considering the anthropomorphic phantom, which allows internal anatomical variations only within the nasal cavity, the choice of beam angles was deliberate as we aimed to measure the effect of these variations on the delivered dose. Furthermore, with a daily online adaptive approach, there exists flexibility to deviate from standard field arrangements in favor of fields that reduce the integral dose to the normal tissue (Nenoff et al 2021) and to reduce setup margins compared to standard non-adaptive treatment (Bobić et al 2023, Chang et al 2024.…”