A Retrospective Study to Evaluate Discrepancies in Urban Versus Rural Mortality Due to Brain Cancer in the United States

Abstract

Introduction: The study aims to examine the disparities in mortality rates attributed to brain cancer between urban and rural areas over a 22-year period, totaling 315,538 deaths. This investigation serves as a crucial step in identifying areas within healthcare that require improvement. By pinpointing the variations in mortality rates between urban and rural settings, healthcare authorities can strategically implement necessary interventions.Methodology: A retrospective study was conducted by analyzing the death certificate available on the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database from 1999 to 2020 to evaluate the mortality rate trends of brain cancer ( International Classification of Diseases (ICD)-10 C71.0-71.9).The data was grouped based on rural and urban death rates according to the 2013 urbanization classification and the variables that were used were age, gender and race. Data was analyzed using Microsoft Excel and R Studio 4.3.1. Significant associations between demographic variables and mortality rates were identified via Binomial tests.Results: From 1999 to 2020, urban areas recorded 259,402 deaths attributed to brain cancer, compared to 56,136 deaths in rural areas, indicating a higher mortality rate in urban settings. The mortality rate in both rural and urban areas exhibited an upward trend, except for a slight drop in 2010. The mortality rates were significantly higher in rural areas compared to urban areas for age groups 55-64 years and 65-74 years, males and caucasians.Conclusions: Our research underscores the differences in death rates from brain cancer between urban and rural areas, specifically among individuals aged 55-64 and 65-74, males and those of caucasian ethnicity. Future research must adopt a multifaceted approach, integrating more recent datasets and embracing a finer granularity of individual-level information. Moreover, there is a pressing need to explore the interplay of various factors such as access to healthcare, treatment modalities, genetic predispositions, and socioeconomic determinants on mortality outcomes.