A review about the development of fucoidan in antitumor activity: Progress and challenges

Wu, Lei; Sun, Jing; Su, Xitong; Qin, Yu; Yu, Qiuyang; Zhang, Peng

doi:10.1016/j.carbpol.2016.08.005

Cited by 171 publications

(130 citation statements)

References 103 publications

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“…Similar results have been reported for low molecular weight fucoidans from other seaweeds [110]. In fact, an in vivo study has already been carried out revealing that the combination of cyclophosphamide with medium molecular weight (20–40 kDa) fucoidan from F. evanescens significantly inhibits the number of metastases in C57BL/6 mice transplanted with Lewis lung carcinoma comparing to the administration of the drug alone [111]. In turn, native F. evanescens fucoidan but not their low molecular weight fragments exhibited anticancer activities in both human malignant melanoma cell lines SK-MEL-28 and SK-MEL-5, which was attributed to the lower sulfonation degree of the low molecular weight fragments compared to the native fucoidan [112].…”

Section: Nutrient Composition Of Fucus Sppsupporting

confidence: 77%

Phycochemical Constituents and Biological Activities of Fucus spp.

2018

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Seaweeds are known to be a good supply of key nutrients including carbohydrates, protein, minerals, polyunsaturated lipids, as well as several other health-promoting compounds capable of acting on a wide spectrum of disorders and/or diseases. While these marine macroalgae are deeply rooted in the East Asian culture and dietary habits, their major application in Western countries has been in the phycocolloid industry. This scenario has however been gradually changing, since seaweed consumption is becoming more common worldwide. Among the numerous edible seaweeds, members of the genus Fucus have a high nutritional value and are considered good sources of dietary fibers and minerals, especially iodine. Additionally, their wealth of bioactive compounds such as fucoidan, phlorotannins, fucoxanthin and others make them strong candidates for multiple therapeutic applications (e.g., antioxidant, anti-inflammatory, anti-tumor, anti-obesity, anti-coagulant, anti-diabetes and others). This review presents an overview of the nutritional and phytochemical composition of Fucus spp., and their claimed biological activities, as well as the beneficial effects associated to their consumption. Furthermore, the use of Fucus seaweeds and/or their components as functional ingredients for formulation of novel and enhanced foods is also discussed.

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Section: Nutrient Composition Of Fucus Sppsupporting

confidence: 77%

Phycochemical Constituents and Biological Activities of Fucus spp.

2018

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“…Mozuku fucoidan is mainly composed of fucose-enriched sulfated polysaccharide with a molecular weight of 28.8 kDa (Figure 2) [4]. Fucodan exhibits many different biological properties, including anti-inflammatory, anticoagulant, antithrombotic, antiadhesive, antiangiogenic, antiviral, antitumor and antioxidant activities [5,6,7,8,9,10]. Currently, the clinical trials of fucoidan have been reported in patients with osteoarthritis and malignant tumors [11,12,13,14] and in the immunocompromised elderly [15].…”

Section: Introductionmentioning

confidence: 99%

Absorption Study of Mozuku Fucoidan in Japanese Volunteers

et al. 2018

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We performed an oral administration study of fucoidan in 396 Japanese volunteers and investigated significant factors concerning the absorption of fucoidan. Urine samples were collected at 0, 3, 6, and 9 h after ingestion of 3 g of fucoidan. Fucoidan was detected in urine after ingestion in 385 out of 396 subjects. The maximum value (mean ± standard deviation (SD)) of urinary fucoidan was 332.3 ± 357.6 μg/gCr in subjects living in Okinawa prefecture, compared with 240.1 ± 302.4 μg/gCr in subjects living outside Okinawa. Compared with the estimated urinary excretion of fucoidan by place of residence, those of subjects living in Okinawa prefecture were significantly higher than those living outside Okinawa prefecture (p < 0.01). In addition, subjects living in Okinawa prefecture consumed significantly greater amounts of mozuku compared with those living outside Okinawa prefecture (p < 0.01). Multiple regression analysis showed that having Okinawa prefecture as a place of residence was a significant factor (p < 0.01) contributing to the estimated urinary excretion of fucoidan. Because the habit of eating mozuku was significantly higher (p < 0.01) in subjects living in Okinawa prefecture than in those living outside Okinawa prefecture, the habit of eating mozuku was speculated to be a factor in the absorption of fucoidan.

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“…The structure of fucoidan and its composition strongly depend on the extraction source (the type of algae) and the method of extraction, thereby affecting its effectiveness. Fucoidan extracted from different species has varied biological activities, including anti-coagulant [19], antioxidant [20], immunomodulatory [21], anti-inflammatory [22], antibacterial activity [23], and anti-obesity [24,25] properties. Alternatively, different processing methods are also important factors that influence the molecular conformational changes.…”

Section: Introductionmentioning

confidence: 99%

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression

Chen

Huang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Uterine leiomyomas (ULs) are benign uterine tumors, and the most notable pathophysiologic feature of ULs is excessive accumulation of extracellular matrix (ECM). Fucoidan is a polysaccharide extracted from brown seaweeds that has a wide range of pharmacological properties, including anti-fibrotic effects. We aimed to study the effect of fucoidan on the growth of ULs activated by transforming growth factor beta (TGFβ). Methods: We used ELT-3 (Eker rat leiomyoma tumor-derived cells) and HUtSMC (human uterine smooth muscle cells) as in vitro models. Cell viability was determined by the MTT assay. Cell colony formation was stained using crystal violet. The side population, cell cycle and apoptosis were analyzed using flow cytometry. Protein expression was assayed by western blot analysis. We also conducted in vivo experiments to confirm the inhibitory effects of fucoidan in nude mouse xenograft models. Tumor tissues were assayed by immunohistochemistry analysis. Results: In our study, fucoidan caused a 50% growth inhibition using a dose of 0.5 mg/ml and decreased the stem cell activity after 48 h. In addition, fucoidan induced sub-G1 cell cycle arrest and apoptosis. Fucoidan down-regulated fibronectin, vimentin, α-SMA and the COL1A1 protein levels in TGFβ3-induced ELT-3 cells. In the cellular mechanism, fucoidan abrogated TGFβ3-induced levels of p-Smad2 and p-ERK1/2, as well as β-catenin translocation into the nucleus. Furthermore, fucoidan suppressed xenograft tumor growth in vivo. Conclusion: Fucoidan displays anti-proliferation and anti-fibrotic effects and exerts protective effects against ULs development.

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A review about the development of fucoidan in antitumor activity: Progress and challenges

Cited by 171 publications

References 103 publications

Phycochemical Constituents and Biological Activities of Fucus spp.

Phycochemical Constituents and Biological Activities of Fucus spp.

Absorption Study of Mozuku Fucoidan in Japanese Volunteers

Fucoidan Inhibits the Proliferation of Leiomyoma Cells and Decreases Extracellular Matrix-Associated Protein Expression

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