A review article on nanotechnology in aquaculture sustainability as a novel tool in fish disease control

Nasr-Eldahan, Sameh; Nabil-Adam, Asmaa; Shreadah, Mohamed A.; Maher, A.; Ali, Tamer El-Sayed

doi:10.1007/s10499-021-00677-7

Cited by 85 publications

(37 citation statements)

References 102 publications

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“…They showed that oral nanovaccines can be used in fish aquaculture (Angulo et al 2020 ). Another recent study reported that selenium nanoparticles have proven to be a novel tool for controlling various bacterial as well as viral fish diseases (Nasr-Eldahan et al 2021 ).…”

Section: Types Of Vaccines For Fish Pathogens In Aquaculture and Thei...mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

2022

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Globally, aquaculture has faced serious economic problems due to bacterial, viral, and various other infectious diseases of different origins. Even though such diseases are being detected and simultaneously treated with several therapeutic and prophylactic methods, the broad-spectrum activity of vaccines plays a vital role as a preventive measure in aquaculture. However, treatments like use of antibiotics and probiotics seem to be less effective when new mutant strains develop and disease causing pathogens become resistant to commonly used antibiotics. Therefore, vaccines developed by using recent advanced molecular techniques can be considered as an effective way of treating disease causing pathogens in aquatic organisms. The present review emphasizes on the current advances in technology and future outlook with reference to different types of vaccines used in the aquaculture industries. Beginning with traditional killed/inactivated and live attenuated vaccines, this work culminates in the review of modern new generation ones including recombinant, synthetic peptides, mucosal and DNA, subunit, nanoparticle-based and plant-based edible vaccines, reverse vaccinology, and monovalent and polyvalent vaccines.

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Section: Types Of Vaccines For Fish Pathogens In Aquaculture and Thei...mentioning

confidence: 99%

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

2022

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“…In this study, chitosan was remarkably noticed as a proper biomolecule for derivatizing nanotubes. The biological function of chitosan and its derivatives (such as glycated chitosan, sulfated chitosan and trimethyl chitosan) have contributed to the immunostimulatory effect, and thus, it has been applied as a vaccine adjuvant and biologics delivery system [ 62 , 63 , 64 , 65 ]. However, even though HACF also contains chitosan, its immunostimulation and protection were not as similar as HCF.…”

Section: Discussionmentioning

confidence: 99%

A Novel Efficient Piscine Oral Nano-Vaccine Delivery System: Modified Halloysite Nanotubes (HNTs) Preventing Streptococcosis Disease in Tilapia (Oreochromis sp.)

et al. 2022

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Generally, the injection method is recommended as the best efficient method for vaccine applications in fish. However, labor-intensive and difficult injection for certain fish sizes is always considered as a limitation to aquatic animals. To demonstrate the effectiveness of a novel oral delivery system for the piscine vaccine with nano-delivery made from nano clay, halloysite nanotubes (HNTs) and their modified forms were loaded with killed vaccines, and we determined the ability of the system in releasing vaccines in a mimic digestive system. The efficaciousness of the oral piscine vaccine nano-delivery system was evaluated for its level of antibody production and for the level of disease prevention in tilapia. Herein, unmodified HNTs (H) and modified HNTs [HNT-Chitosan (HC), HNT-APTES (HA) and HNT-APTES-Chitosan (HAC)] successfully harbored streptococcal bivalent vaccine with inactivated S. agalactiae, designated as HF, HAF, HCF and HACF. The releasing of the loading antigens in the mimic digestive tract demonstrated a diverse pattern of protein releasing depending on the types of HNTs. Remarkably, HCF could properly release loading antigens with relevance to the increasing pH buffer. The oral vaccines revealed the greatest elevation of specific antibodies to S. agalactiae serotype Ia in HCF orally administered fish and to some extent in serotype III. The efficacy of streptococcal disease protection was determined by continually feeding with HF-, HAF-, HCF- and HACF-coated feed pellets for 7 days in the 1st and 3rd week. HCF showed significant RPS (75.00 ± 10.83%) among the other tested groups. Interestingly, the HCF-treated group exhibited noticeable efficacy similar to the bivalent-vaccine-injected group (RPS 81.25 ± 0.00%). This novel nano-delivery system for the fish vaccine was successfully developed and exhibited appropriated immune stimulation and promised disease prevention through oral administration. This delivery system can greatly support animals’ immune stimulation, which conquers the limitation in vaccine applications in aquaculture systems. Moreover, this delivery system can be applied to carrying diverse types of biologics, including DNA, RNA and subunit protein vaccines.

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“…Nanotechnology, as a novel and revolutionary technique, offers a wide range of applications and enormous potential in aquaculture and seafood preservation. It has the potential to develop new technologies for drug management and vaccine development, ensuring the protection of fisheries resources against disease-causing microorganisms (Nasr-Eldahan et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Antibiotic resistance in aquaculture and aquatic organisms: a review of current nanotechnology applications for sustainable management

Okeke

Chukwudozie

Nyaruaba

et al. 2022

Environ Sci Pollut Res

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Aquaculture has emerged as one of the world’s fastest-growing food industries in recent years, helping food security and boosting global economic status. The indiscriminate disposal of untreated or improperly managed waste and effluents from different sources including production plants, food processing sectors, and healthcare sectors release various contaminants such as bioactive compounds and unmetabolized antibiotics, and antibiotic-resistant organisms into the environment. These emerging contaminants (ECs), especially antibiotics, have the potential to pollute the environment, particularly the aquatic ecosystem due to their widespread use in aquaculture, leading to various toxicological effects on aquatic organisms as well as long-term persistence in the environment. However, various forms of nanotechnology-based technologies are now being explored to assist other remediation technologies to boost productivity, efficiency, and sustainability. In this review, we critically highlighted several ecofriendly nanotechnological methods including nanodrug and vaccine delivery, nanoformulations, and nanosensor for their antimicrobial effects in aquaculture and aquatic organisms, potential public health risks associated with nanoparticles, and their mitigation measures for sustainable management. Graphical abstract

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A review article on nanotechnology in aquaculture sustainability as a novel tool in fish disease control

Cited by 85 publications

References 102 publications

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

A review on the recent advances and application of vaccines against fish pathogens in aquaculture

A Novel Efficient Piscine Oral Nano-Vaccine Delivery System: Modified Halloysite Nanotubes (HNTs) Preventing Streptococcosis Disease in Tilapia (Oreochromis sp.)

Antibiotic resistance in aquaculture and aquatic organisms: a review of current nanotechnology applications for sustainable management

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