A review of diffusion tensor magnetic resonance imaging computational methods and software tools

Hasan, Khader M.; Walimuni, Indika S.; Abid, Humaira; Hahn, Klaus

doi:10.1016/j.compbiomed.2010.10.008

Cited by 79 publications

(67 citation statements)

References 146 publications

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“…Third, in our study, the anisotropic voxels of DTI data were acquired because we attempted to retain whole-brain coverage in a shorter scanning time for the schizophrenic patients, while keeping a reasonably small in-plane resolution. However, although the anisotropic voxels of DTI data are commonly used [34,60] , it should be noted that their use may partially impact the accuracy of the directionality of the diffusion tensor [61][62][63] . In a future study, we will use isotropic voxel sizes to ensure the accuracy of the fi ber tractography.…”

Section: Discussionmentioning

confidence: 99%

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

et al. 2015

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Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their firstdegree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands (19 patients and 41 unaffected parents) and two unrelated groups of normal controls (24 controls matched with patients and 26 controls matched with relatives). The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global effi ciency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology.We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that (1) the global effi ciency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and (2) genetic vulnerability to schizophrenia may influence the anatomical organization of an individual's brain networks.

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Section: Discussionmentioning

confidence: 99%

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

et al. 2015

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“…Regional assessment can be enabled by region-ofinterest (ROI) analysis [73]. Whole brain analyses are performed using voxel-based analysis (VBA) or tract-based spatial statistics (TBSS; Fig.…”

Section: Dti-based White Matter Assessmentmentioning

confidence: 99%

“…Deterministic tractography uses the principal eigenvector information in combination with FA and anatomical knowledge through seed and target ROIs [73]. However, deterministic tractography methods are impeded by the limited knowledge on the possible error of deviance caused by the tracking procedure [73]. On the other hand, probabilistic tractography incorporates the uncertainty into the tracking algorithm and produces connectivity metric at each voxel ( Fig.…”

Section: Dti-based White Matter Assessmentmentioning

confidence: 99%

“…A selection of the different approaches, the related software and the study groups is shown in Table 3. Deterministic tractography uses the principal eigenvector information in combination with FA and anatomical knowledge through seed and target ROIs [73]. However, deterministic tractography methods are impeded by the limited knowledge on the possible error of deviance caused by the tracking procedure [73].…”

Section: Dti-based White Matter Assessmentmentioning

confidence: 99%

“…DTI measures the integrity and architecture of normalappearing CNS structures by estimating displacement of water molecules along and perpendicular to white matter tracts [13,73]. In each imaging voxel, DTI estimates a local diffusion profile as an ellipsoid (Fig.…”

Section: Diffusion Tensor Imaging Dti Indices and Their Correlations mentioning

confidence: 99%

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Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system

et al. 2017

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The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS. Since MS damage patterns are believed to depend on multiple factors, i.e., ON (anterior visual pathway damage), inflammatory lesions (posterior visual pathway damage), and global diffuse inflammatory and neurodegenerative processes, comprehensive knowledge on different contributing factors using DTI in vivo may advance our understanding of MS disease pathology. Combination of DTI measures and visual outcome parameters yields the potential to improve routine clinical diagnostic procedures and may further the accuracy of individual prognosis with regard to visual function and personalized disease outcome. However, due to the inherent limitations of DTI acquisition and post-processing techniques and the so far heterogeneous and equivocal data of previous studies, evaluation of the true potential of DTI as a possible biomarker for afferent visual pathway dysfunction is still substantially limited. Further research efforts with larger longitudinal studies and standardized DTI acquisition and post-processing validation criteria are needed to overcome current DTI limitations. DTI evaluation at different levels of the visual pathway has the potential to provide markers for individual damage evaluation in the future. As an imaging biomarker, DTI may support individual outcome prediction during personalized treatment algorithms in MS and other neuroinflammatory diseases, hereby leveraging the concept of predictive, preventive, and personalized medicine in the field of clinical neuroimmunology.

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Diffusion MRI

Demnitz¹,

Sexton²

2020

The Wiley Encyclopedia of Health Psychology

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A review of diffusion tensor magnetic resonance imaging computational methods and software tools

Cited by 79 publications

References 146 publications

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system

Diffusion MRI

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