A Review of Isolation, Chemical Properties, and Bioactivities of Polysaccharides from Bletilla striata

Abstract

Recently, polysaccharides from Bletilla striata, a member of the orchidaceous family, aroused the wide interest of people, especially their isolation, chemical properties, and bioactivities. It is reported that these polysaccharides are the most important biologically active components of B. striata, exhibiting various biological activities, such as immunomodulatory, antioxidant, antifibrotic, and hemostatic effects. This review appraised the available literatures which described different aspects of B. striata polysaccharides, including the extraction, separation, purification, structural characterization, and biological activities. We expect to lay the foundation for further investigation of the application of B. striata polysaccharides in the field of functional foods and biomedicine.

Bletilla striata Polysaccharides: Structures and Functional Activities

“…After concentration, the purified BSPs were obtained from eluent. [2] Finally, purified BSPs have been widely studied in many aspects (Figure 1).…”

“…BSPs had significant antitumor activities in vivo and in vitro. [2] Li et al [53] found that previously investigated the in vivo and in vitro effects of paclitaxel nanoparticle-(PTX-) loaded BSPs on human gastric cancer cells. The results suggested that BSP-loaded paclitaxel nanoparticles could realize enhanced drug delivery and exert an antiproliferative effect on the human gastric gland cancer cell line (MKN45) effectively and safely both in vivo and in vitro.…”

“…[1] It is reported that these polysaccharides are the most important biologically active components of B. striata with various bioactivities. [2] Clinically, it is mainly used to treat hemoptysis, traumatic hemorrhage, gastrointestinal mucosal injury, ulcers, bruises and burns, anorectal diseases, gynecological fibroma, tumor embolization and prostate surgery, etc. [3][4][5][6] Polysaccharides were extracted from B. striata.…”

Organ-specific, integrated omics data-based study on the metabolic pathways of the medicinal plant Bletilla striata (Orchidaceae)

“…Especially in China, the dried tubers of B. striata , recorded as “Bai ji” in Chinese pharmacopoeia (2010), has been used as a traditional Chinese medicine (TCM) for thousands of years. In the modern times, many beneficial health effects of B. striata , such as healing, hemostasis, antioxidation, antiinflammation, antifibrotic and immunomodulatory activities, have been uncovered by the recent phytochemical and pharmacological studies [ 2 , 3 ]. Recently, China Food and Drug Administration has approved four patent medicines including “Bai ji” Pill, “Bai ji” Capsule, “Bai ji” Syrup, and “Bai ji” Granule, all of which contain B. striata as the unique medicinal ingredient [ 2 ].…”

Mucoadhesive Bletilla striata Polysaccharide-Based Artificial Tears to Relieve Symptoms and Inflammation in Rabbit with Dry Eyes Syndrome

“…Polysaccharides have attained limelight due to their various biologic properties, nontoxicity and biodegradable nature [ 21 ]. BSP is known to possess anti-inflammatory, antioxidant and antiviral properties [ 22 , 23 ]. Previous study showed that polysaccharides from Bletilla striata can successfully alleviate ROS generation and proinflammatory cytokines activation induced by Angiotensin II in human mesangial cells (HMCs), exhibiting antioxidant and anti-inflammatory properties of BSP [ 24 ].…”