A review of normal concentrations of mercury in human blood

Brune, Dag; Nordberg, Gunnar F.; Vesterberg, Olof; Gerhardsson, Lars; Wester, Per

doi:10.1016/0048-9697(91)90380-w

Cited by 86 publications

(46 citation statements)

References 67 publications

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“…Brune et al reviewed Hg biomarker studies -published from 1976 to 1990 -of general populations exposed through various sources and found the highest values among seafood consumers in Greenland and Japan. 197 Sioen et al estimated contaminant and nutrient intake in general populations based on global seafood availability data and found the estimated MeHg intake to be highest in Japan and the Pacific islands, followed by the Nordic and Mediterranean regions. 198 A recent European regional study examining biomarkers showed the highest MeHg exposure to be in Mediterranean countries.…”

Section: Discussionmentioning

confidence: 99%

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

Sheehan

Burke

Navas‐Acien

et al. 2014

Bull. World Health Organ.

238

124

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Section: Discussionmentioning

confidence: 99%

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

Sheehan

Burke

Navas‐Acien

et al. 2014

Bull. World Health Organ.

238

124

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“…Vitamin E would be playing a leading role in protecting cellular membranes from methylmercury 17 . The main problem presented by the determination of mercury is the possible contamination that may occur as a result of reagents and the environment during the sample preparation process and in the subsequent chemical analysis 42 . The negative results found in the mercury determination tests performed on straws and different solutions used in the processing of biological samples exclude a possible confusion factor.…”

Section: Discussionmentioning

confidence: 99%

Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain

Sanzo

Dorronsoro²,

Amiano³

et al. 2001

Public Health Nutr.

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Objective: To estimate mercury intake due to fish consumption among the individuals from Gipuzkoa participating in the European Prospective Investigation into Cancer (EPIC), and to validate the estimation of mercury exposure through diet, by measuring blood mercury level. Design and setting: The population for the EPIC Gipuzkoa cohort was recruited from 1992 to 1995. Each individual's diet was assessed regarding habitual intake over the previous year, using the diet history method. Blood samples were taken at the time of the interview. The mercury content of the fish species consumed was supplied by the Food Chemical Surveillance Programme in the Basque Country. Subjects: For the estimation, 8417 volunteers, men and women, aged 35±65 years, of the EPIC cohort; for the validation, a random sample of 120 individuals stratified by fish intake was taken.

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“…Recently, the scope of the project has been widened to include the most essential and nonessential elements. In the course of the work by the Tracy group, tentative reference intervals have been presented, for example, for mercury (7) and chromium (8). A thorough description of the principles for the work of this expert group has recently been given by Vesterberg et a1 (9).…”

mentioning

confidence: 99%

Evaluation of selected publications on reference values for lead in blood

Gerhardsson

Kazantzis²,

Schütz³

1996

Scand J Work Environ Health

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. Evaluation of selected publications on reference values for lead in blood. 1996;22:325-31. Scand J Work Environ HealthAs a part of the global Tracy project, whose aim is to define metal concentrations in tissues and body fluids of reference populations, more than 1000 papers published from 1980 to 1994 were scrutinized that presented tentative reference values for lead in blood in occupationally unexposed adult populations. Ten studies exemplifying criteria for proper sampling, analysis and data treatment are presented and discussed. Levels of lead in blood are influenced by numerous factors. Accordingly, a wide variation in blood lead concentrations was observed. As an example, in a global study in 1983 of nonsmoking female schoolteachers, the geometric mean value for lead in blood varied from 52 yg . I-' in Tolcyo, Japan, up to 193 yg . I-' in Mexico City. The Tracy survey de~uonstrates the importance of factors such as age, gender, ethnicity, food, drinking and smoking habits, hobbies, season and year of sampling, residential area, and geographic location. Lead in blood was shown to be both time and area specific. Thus it was not possible to establish a general reference value for lead in blood.Key terms inorganic lead.Lead has many uses in society. World-wide emission of lead occurs through the use of leaded gasoline (1). Industrial emissions may also contribute, in some areas, to increased lead levels in air, food, and water. Lead has been a constituent in house paint in some countries (2). Furthermore, the use of lead pipes in fresh water systems and the use of lead-glazed household ceramics may substantially increase lead intake (3).The absorption of lead from the gastroi~ltestinal tract is about 10% in adults, but can be considerably higher in children (4). It increases when a person's diet is deficient in calcium and iron. In occupational settings, the main intake is through inhalation. Absorption through the respiratory tract is influenced by the size and solubility of the inhaled particles.After absorption into blood plasma, lead is quicltly taken up by the red blood cells, which contain about 99% of the lead in whole blood (5). Thus far, lead in whole blood (B-Pb) has been the main indicator medium used for the biological ~nonitoring of humans. As an indicator of exposure and of internal dose, B-Pb is a mandatory requirement for the biological monitoring of lead-exposed worl

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A review of normal concentrations of mercury in human blood

Cited by 86 publications

References 67 publications

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

Global methylmercury exposure from seafood consumption and risk of developmental neurotoxicity: a systematic review

Estimation and validation of mercury intake associated with fish consumption in an EPIC cohort of Spain

Evaluation of selected publications on reference values for lead in blood

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