A review of plant characteristics, phytochemistry and bioactivities of the genus Glechoma

Zhou, Ying; He, Yun; Wang, Zhaojie; Hu, Bin‐Yuan; Xie, Tian-Zhen; Xiao, Xincai; Zhou, Zhong-Shun; Sang, Xu-Yan; Luo, Xiao‐Dong

doi:10.1016/j.jep.2021.113830

Cited by 12 publications

(10 citation statements)

References 49 publications

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“…The aerial parts of G. hederacea have been used in traditional medicine for centuries to treat colds, asthma, bronchitis, gastric diseases, diabetes, and inflammation [ 2 , 3 ]. G. hederacea provides anti-inflammatory, analgesic, antibacterial, antiviral, anticancer, diuretic, and antioxidant properties [ 4 , 5 , 6 ]. Its potential use in pharmacy applications [ 7 ] and as a food additive [ 8 ] has been studied.…”

Section: Introductionmentioning

confidence: 99%

“…Both the ethanol and water extracts possessed depigmenting activity in vitro and in vivo [ 2 , 11 ]. The study by Zhou et al [ 6 ] summarizes the various pharmacological uses of G. hederacea and its chemical components that exhibit clinically relevant biological activity. Industrial applications of its extracts to enrich food are possible since no toxicity was detected in the extracts at the tested concentrations (maximum concentration of 10 mg/mL) in the brine shrimp lethality assay [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…G. hederacea contains a variety of secondary metabolites, including terpenoids, flavonoids, phenolic acids, alkaloids, and essential oils, which leads to its pharmacological effects [ 6 ]. Phenolic compounds such as phenolic acids, flavonoids, and their derivatives are the main biologically active substances in polar solvent extracts [ 6 ]. Phenolic compounds have aroused significant interest due to their antiaging, anti-inflammatory, antioxidant, and antiproliferative activities [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

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Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Sīle

Krizhanovska

Nakurte

et al. 2022

Plants

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Glechoma hederacea L. is a medicinal plant that is known in traditional medicine for its anti-inflammatory, antibacterial, antiviral, and anticancer properties. This study evaluated the potential for commercial production of G. hederacea and compared the chemical composition and activity of 70% ethanol extracts and steam-distilled essential oils from wild-grown and cultivated G. hederacea collected in different harvesting periods. The main compounds identified in the 70% ethanol extracts were phenolic acids (chlorogenic and rosmarinic acids) and flavonoid O-glycosides. The essential oil varied in the three accessions in the range of 0.32–2.98 mL/kg−1 of dry weight. The extracts possessed potent antioxidant and anti-inflammatory properties in LPS-treated bone-marrow-derived macrophages. The results of flow cytometry show that extracts from different vegetation periods reduced the conversion of macrophages to the proinflammatory phenotype M1. The chemical composition varied the most with the different harvesting periods, and the most suitable periods were the flowering and vegetative phases for the polyphenolic compounds and essential oils, respectively. G. hederacea can be successfully grown under organic farming conditions, and cultivation does not significantly affect the chemical composition and biological activity compared to wild-grown plants.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Sīle

Krizhanovska

Nakurte

et al. 2022

Plants

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“…Glechoma hederacea L. (Lamiaceae) is herbal medicine in the Labiatae family. Glechoma species reportedly contain various pharmacologically active compounds including flavonoids, polyphenols, terpenoids, alkaloids, steroids, and fatty acids (Zhou et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Phenolic acids and flavonoids‐rich Glechoma hederacea L. (Lamiaceae) water extract against H ₂ O ₂ ‐induced apoptosis in PC12 cells

Chao

Chan

et al. 2021

Journal of Food Biochemistry

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Reactive oxygen species (ROS)-induced oxidative stress is reportedly associated with progressive neuronal cell damage. Glechoma hederacea L. (Lamiaceae), belonging to the Labiatae family, has demonstrated several biologic activities including depigmentation, antimelanogenic, antitumor, antioxidative, hepatoprotective, and antiinflammatory activities. Previously, we reported that rosmarinic acid, chlorogenic acid, caffeic acid, rutin, genistin, and ferulic acids were the most abundant phytochemicals detected in hot water extracts of G. hederacea L. (HWG). This study aimed to study the neuroprotective effects of phenolic acids and flavonoid-rich HWG against hydrogen peroxide (H 2 O 2 )-induced oxidative damage in PC12 cells and its inhibitory effect on acetylcholinesterase (AChE). The experiment analyzed cytotoxicity, ROS production, mitochondrial transmembrane potential (MMP) level, and caspase-3 activity and used comet assay and antioxidant enzyme activity to determine the redox status of PC12 cells. Results showed that the inhibitory effect of HWG on AChE was in a competitive pattern (IC 50 , 23.23 mg/ml). HWG antagonized H 2 O 2 -mediated cytotoxicity and DNA damage, reduced ROS production, stabilized MMP, and inhibited caspase-3 activity and apoptosis. Furthermore, HWG inhibited the release of cytochrome C and apoptosis-inducing factors (AIF) and decreased the malondialdehyde levels in PC12 cells. Collectively, HWG rich in antioxidant phenolic acids and flavonoids may have neuroprotective effects. Practical applicationsPolyphenolic compounds are one of the most important natural products, known to possess a range of health-promoting effects. In this study, it was found that HWG, which is rich in antioxidant phenolic acids and flavonoids, can protect PC12 cells from oxidative stress induced by H 2 O 2 and may have neuroprotective effects.

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“…Over the years, medicinal plants have been used in many human populations all over the world [3] in the treatment of different ailments and diseases. This is largely due to their health benefits, effectiveness [4], affordability, and little or no side effects when compared to synthetic drugs that are expensive and may have adverse effects [5].…”

Section: Introductionmentioning

confidence: 99%

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Olatunji

Adetunji

Olisah

et al. 2021

Plants

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The genus Merremia Dennst. ex Endl. (Convolvulaceae) is a rich source of structurally diverse phytochemicals with therapeutic relevance. This review presents the first comprehensive, up-to-date information and research progression on the nutritional value, ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicity of the genus Merremia. Using the key search term “Merremia”, relevant documents and information were retrieved from electronic databases. Relevant documents were uploaded in RStudio with installed bibliometric software packages and used for data retrieval, tabulation, and network visualization. Bibliometric analysis revealed that ca. 55% of the studies related to Merremia were published in the last decade, which can be grouped into four thematic areas: (i) drug formulation, (ii) taxonomy, (iii) chemical analysis, and (iv) treatment of diseases. Ethnomedicinal uses, phytochemistry, and biological activities studies showed that species in the genus are promising medicinal plants with various pharmaceutical potentials. However, clinical studies to validate the efficacy of the reported bioactivities and the mechanisms underlying the various activities are lacking and should constitute a future research focus. Additionally, reports on the nutritional and antinutritional constituents of Merremia species revealed that the species meet high nutritional quality criteria for animals and are therefore suitable for inclusion in livestock diets. The few available investigations on toxicity indicated that most Merremia species are safe for human and animal use but not with prolonged chronic administration.

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A review of plant characteristics, phytochemistry and bioactivities of the genus Glechoma

Cited by 12 publications

References 49 publications

Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Phenolic acids and flavonoids‐rich Glechoma hederacea L. (Lamiaceae) water extract against H ₂ O ₂ ‐induced apoptosis in PC12 cells

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

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A review of plant characteristics, phytochemistry and bioactivities of the genus Glechoma

Cited by 12 publications

References 49 publications

Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Wild-Grown and Cultivated Glechoma hederacea L.: Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Phenolic acids and flavonoids‐rich Glechoma hederacea L. (Lamiaceae) water extract against H 2 O 2 ‐induced apoptosis in PC12 cells

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

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Phenolic acids and flavonoids‐rich Glechoma hederacea L. (Lamiaceae) water extract against H ₂ O ₂ ‐induced apoptosis in PC12 cells