A review of the properties and applications of bioadhesive hydrogels

Xiong, Yingshuo; Zhang, Xiaoran; Ma, Xintao; Wang, Wenqi; Yan, Feiyan; Zhao, Xiaohan; Chu, Xiaoxiao; Xu, Wenlong; Sun, Changmei

doi:10.1039/d1py00282a

Cited by 109 publications

(64 citation statements)

References 211 publications

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“…Bioadhesive hydrogel formulations through adhesion to the skin, prolong the contact time of the formulation at the site of application, which improves penetration and the efficiency of the local therapy. In addition, through skin hydration, hydrogels improve drug permeation [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Does the Freeze–Thaw Technique Affect the Properties of the Alginate/Chitosan Glutamate Gels with Posaconazole as a Model Antifungal Drug?

Szekalska

Sosnowska

Wróblewska

et al. 2022

IJMS

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Hydrogels are semi-solid systems with high flexibility, which, due to holding large amounts of water, are similar to natural tissues and are very useful in the field of biomedical applications. Despite the wide range of polymers available to form hydrogels, novel techniques utilized to obtain hydrogels with adequate properties are still being developed. The aim of this study was to evaluate the impact of the freeze–thaw technique on the properties of cryogels based on sodium alginate and chitosan glutamate with posaconazole as a model antifungal substance. The effect of the freezing and thawing process on the physicochemical, rheological, textural and bioadhesive properties of prepared cryogels was examined. Additionally, the antifungal activity against Candida albicans, Candida parapsilosis and Candida krusei of designed formulations was examined. It was shown that the freeze–thaw technique significantly improved viscosity, bioadhesiveness, textural properties and prolonged the in vitro posaconazole release. Moreover, alginate/chitosan glutamate cryogels exhibited higher values of inhibition zone in C. parapsilosis culture than traditional hydrogel formulations.

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Section: Resultsmentioning

confidence: 99%

Does the Freeze–Thaw Technique Affect the Properties of the Alginate/Chitosan Glutamate Gels with Posaconazole as a Model Antifungal Drug?

Szekalska

Sosnowska

Wróblewska

et al. 2022

IJMS

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“…Overall, hydrogel-based wound dressings offer promising solutions in broad aspects for the treatment of chronic wounds [ 43 , 44 ]. In the next section, the functionalities of these hydrogels are discussed in detail with recent literature examples for chronic wound healing.…”

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

“…Drug or therapeutic agent releasing hydrogels can provide controlled and sustained delivery in response to the environmental stimuli. Overall, hydrogel-based wound dressings offer promising solutions in broad aspects for the treatment of chronic wounds [43,44]. In the next section, the functionalities of these hydrogels are discussed in detail with recent literature examples for chronic wound healing.…”

Section: Functional Hydrogels For Chronic Wound Healingmentioning

confidence: 99%

Functional Hydrogels for Treatment of Chronic Wounds

Firlar

Altunbek

McCarthy

et al. 2022

Gels

107

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Chronic wounds severely affect 1–2% of the population in developed countries. It has been reported that nearly 6.5 million people in the United States suffer from at least one chronic wound in their lifetime. The treatment of chronic wounds is critical for maintaining the physical and mental well-being of patients and improving their quality of life. There are a host of methods for the treatment of chronic wounds, including debridement, hyperbaric oxygen therapy, ultrasound, and electromagnetic therapies, negative pressure wound therapy, skin grafts, and hydrogel dressings. Among these, hydrogel dressings represent a promising and viable choice because their tunable functional properties, such as biodegradability, adhesivity, and antimicrobial, anti-inflammatory, and pre-angiogenic bioactivities, can accelerate the healing of chronic wounds. This review summarizes the types of chronic wounds, phases of the healing process, and key therapeutic approaches. Hydrogel-based dressings are reviewed for their multifunctional properties and their advantages for the treatment of chronic wounds. Examples of commercially available hydrogel dressings are also provided to demonstrate their effectiveness over other types of wound dressings for chronic wound healing.

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“…Furthermore, these membranes must be non-toxic and biocompatible to minimize the risk of epithelialization or allergic reactions. In this context, the use of enzymes [54][55][56][57], hydrogels [6,41,[58][59][60], and conductive polymers such as polyaniline (PANI) [61][62][63][64], polypyrrole (PPy) [65][66][67], polythiophene (PT) [68][69][70], or polyethylene dioxide thiophene (PEDOT) [43,[71][72][73][74] has been reported for the development of bioelectrodes due to their biocompatibility, conductivity, and the presence of tunable functionalities. However, its application in the development of biosensors is limited by different reasons and challenges to overcome, such as its relative fragility; its decrease in properties against variations in the pH of the medium, possible degradation in toxic or reactive compounds; and in some cases the use of synthesis processes and complex manufacturing procedures that are difficult to implement outside the laboratory scale [70][71][72][73][74][75][76].…”

Section: Wearable Membranes Sensormentioning

confidence: 99%

Advanced Functional Membranes for Sensor Technologies

Hernández-Martínez

2022

Advanced Functional Membranes

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Sensors are modern data acquisition devices intended for detecting a specific change in the surrounding area and responding with an output signal. Among them, biological sensors (or biosensors) are of great interest due to their capacity for detecting molecules that indicate changes in people's health. This chapter provides an overview of the polymeric membranes that have novel or advanced functions in applications for the development of lab-on-chip or sensor technologies. Important approaches in this matter include the improvement of membranes as supporting medium of recognition element of the sensor, advances in membrane composition for protecting the integrity of target molecules, or the option to filter undesired components. The chapter is divided into three sections: membrane fabrication, molecular probes and platforms for reading sensor devices.

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A review of the properties and applications of bioadhesive hydrogels

Abstract: Due to their outstanding properties, bioadhesive hydrogels have been extensively studied by researchers in recent years. By designing the properties of bioadhesive hydrogel, it can be reasonably applied to biomedicine....

Cited by 109 publications

References 211 publications

Does the Freeze–Thaw Technique Affect the Properties of the Alginate/Chitosan Glutamate Gels with Posaconazole as a Model Antifungal Drug?

Does the Freeze–Thaw Technique Affect the Properties of the Alginate/Chitosan Glutamate Gels with Posaconazole as a Model Antifungal Drug?

Functional Hydrogels for Treatment of Chronic Wounds

Advanced Functional Membranes for Sensor Technologies

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