A Review on Analytical Method for Determination of Venlafaxine HCl in Bulk and Pharmaceutical dosage form

Dighe, S.; Siddheshwar, Suhas; Shinde, Ganesh S.

doi:10.52711/2349-2988.2021.00032

RJST

2021

DOI: 10.52711/2349-2988.2021.00032

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A Review on Analytical Method for Determination of Venlafaxine HCl in Bulk and Pharmaceutical dosage form

S. Dighe

Suhas Siddheshwar

Ganesh S. Shinde

Abstract: Venlafaxine HCl is one of the antidepressant agent which comes under the category of serotonin-norepinephrine reuptake inhibitor i.e SNRI. This medication is usually used to treat major depressive disorder in adult. It may help to improve the mood and energy level and also to regain the interest in daily activities in the depressed person. The present review focus on various approaches for the analysis on Venlafaxine in bulk and pharmaceutical dosage forms. The review represents the various analytical method l… Show more

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2024

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Cited by 3 publications

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High-performance liquid chromatography-based analytical techniques for simultaneous determination of Naltrexone hydrochloride (NTX) and Bupropion hydrochloride (BUP): a comprehensive review

Zehra,

Saeed,

Zaman

et al. 2024

Discov Appl Sci

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The confluence of Bupropion Hydrochloride and Naltrexone Hydrochloride within a composite pharmaceutical formulation has garnered the prestigious endorsement of the U.S. Food and Drug Administration (FDA) for its targeted application in addressing the pervasive issue of obesity. Naltrexone hydrochloride, a semi-synthetic opioid compound, exerts its therapeutic influence through competitive antagonism of the mu receptors, while Bupropion hydrochloride, a tricyclic antidepressant, operates by impeding the reuptake of dopamine, thus amplifying its activity in distinctive cerebral domains. Notably, Naltrexone's impact is modulated through the intricate manipulation of pro-opiomelanocortin neurons within the hypothalamus, underscoring the amalgamated efficacy of this unique tandem in the protracted management of obesity. This scholarly exposition focalizes on the meticulous delineation of high-performance liquid chromatography (HPLC)-based analytical methodologies, meticulously tailored for the concurrent quantification of naltrexone hydrochloride (NTX) and bupropion hydrochloride (BUP). This comprehensive review scrutinizes an array of analytical strategies, traversing from archetypal HPLC (high performance liquid chromatography) methodologies to the burgeoning realm of environmentally conscious chromatographic approaches. Each method undergoes scrupulous examination, elucidating the nuanced applications, from the constitution of the mobile phase and judicious column selection to the refinement of optimal flow rates. Moreover, the review orchestrates a comprehensive evaluation of the validation parameters intrinsic to these analytical approaches, fortifying the reliability and precision of their findings. This erudite exploration not only encapsulates the diversity of chromatographic techniques but also expounds on the methodological robustness that underpins the determination of these pharmacologically significant compounds. In doing so, it elevates the pursuit of scientific excellence in pharmaceutical analysis, contributing significantly to the ongoing discourse in this critical field. Graphical abstract

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High-performance liquid chromatography-based analytical techniques for simultaneous determination of Naltrexone hydrochloride (NTX) and Bupropion hydrochloride (BUP): a comprehensive review

Zehra,

Saeed,

Zaman

et al. 2024

Discov Appl Sci

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Implementation of Quality by Design approach for Development of Optimized Drug Delivery System of Antidepressant Drug

Sharma,

Singh,

Jaiswal

et al. 2024

RJPT

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The work presented aimed to implement of “Quality by Design” (QbD) approach to develop optimized fast dissolving tablet (FDT) of Fluoxentine. A face centered Central composite design was employed to develop optimized dosage form. FDTs were prepared by direct compression followed using sublimation technique with additive effect of super disintegrants. Impact of independent variables such as concentration of super-disintegrant and sublimating agent was determined on dependent variables i.e. wetting time, disintegration time and drug release. Data optimization was done by developing validation check batches as well as overlay plot developed by statistical software. Optimized formulation shows 18.08 s wetting time (WT), 19.84 s disintegration time (DT) and the drug release was found to be 85.82 % in 5 m. The accelerated stability studies for optimized FDTs shows no significant changes during one month stability studies. In conclusion, the optimized fast dissolving tablets for Fluoxentine was successfully developed employing by QbD approach with least utilization of man, money and efforts.

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Quantitative Estimation of Flavonoid Quercetin from Borassus flabellifer (L) Germinated Sprout using Validated HPTLC Method

Majumder,

Saha

2024

RJST

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Introduction: Borassus flabellifer L. known as Tal in West Bengal belongs to the Arecaceae family. In the present experiment, we used the endosperm part (germinated sprout). The edible sprout part is a familiar food of the people. However, its flavonoid profiling is not yet reported. Aim: This study aimed to explore the presence of quercetin and its quantitative analysis in the endosperm of Borassus flabellifer. Method: TLC was carried out with an established solvent system toluene: ethyl acetate: formic acid (5:4:0.2, v/v/v), to detect quercetin. A validated HPTLC method was devolved by using silica gel plates with the established solvent system used in TLC.HPTLC analysis was carried out with the same solvent system toluene: ethyl acetate: formic acid (5:4:0.2, v/v/v). Quantitative estimation was done from the AUC obtained in the plot. Results: The method was confirmed to be specific, and accurate across different measurements. Recovery studies showed recovery 108.50 with RSD (relative standard deviation) % 0.84 of quercetin is retrieved accurately. The germinated sprout was found 0.98mg/100g of quercetin. Conclusion: The HPTLC is an efficient and sensitive tool for the analysis of quercetin in the sample extracts in available products. This is the first-ever described method for this specific purpose, potentially paving the way for quality control and standardization of herbal products of B. flabellifer.

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A Review on Analytical Method for Determination of Venlafaxine HCl in Bulk and Pharmaceutical dosage form

Cited by 3 publications

References 18 publications

High-performance liquid chromatography-based analytical techniques for simultaneous determination of Naltrexone hydrochloride (NTX) and Bupropion hydrochloride (BUP): a comprehensive review

High-performance liquid chromatography-based analytical techniques for simultaneous determination of Naltrexone hydrochloride (NTX) and Bupropion hydrochloride (BUP): a comprehensive review

Implementation of Quality by Design approach for Development of Optimized Drug Delivery System of Antidepressant Drug

Quantitative Estimation of Flavonoid Quercetin from Borassus flabellifer (L) Germinated Sprout using Validated HPTLC Method

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