A review on analytical methods with special reference to electroanalytical methods for the determination of some anticancer drugs in pharmaceutical and biological samples

Safaei, Mohadeseh; Shishehbore, M. Reza

doi:10.1016/j.talanta.2021.122247

Cited by 28 publications

(9 citation statements)

References 208 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The vast majority of these publications concern drug analysis, especially chiral separations. CDs are not only excellent chiral selectors but also have successful positional isomer-selector properties [41][42][43]. Due to its low reagent requirements, flexibility, and sensitivity, capillary electrophoresis (CE) is increasingly paving the way for analytical applications of CDs in pharmaceutical analyses.…”

Section: Cyclodextrins In Drug Analysismentioning

confidence: 99%

Cyclodextrins in the antiviral therapy

Jicsinszky

Martina

Cravotto

2021

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

The main antiviral drug-cyclodextrin interactions, changes in physicochemical and physiological properties of the most commonly used virucides are summarized. The potential complexation of antiviral molecules against the SARS-Cov2 also pointed out the lack of detailed information in designing effective and general medicines against viral infections. The principal problem of the current molecules is the 3D structures of the currently active compounds. Improving the solubility or bioavailability of antiviral molecules is possible, however, there is no universal solution, and the complexation experiments dominantly use the already approved cyclodextrin derivatives. This review discusses the basic properties of the different cyclodextrin derivatives, their potential in antiviral formulations, and the prevention and treatment of viral infections. The biologically active new cyclodextrin derivatives are also discussed.

show abstract

Section: Cyclodextrins In Drug Analysismentioning

confidence: 99%

Cyclodextrins in the antiviral therapy

Jicsinszky

Martina

Cravotto

2021

Journal of Drug Delivery Science and Technology

View full text Add to dashboard Cite

show abstract

“…Various analytical techniques have been used to detect and quantify the blood concentration levels of anticancer drugs. Among these analytical techniques, electrochemical methods, radioimmunoassays, immunohistochemistry, gas chromatography, and high-performance liquid chromatography can all detect specific anticancer drugs [ 11 , 12 , 13 , 14 ]. However, these methods have limitations, such as high equipment cost and complexity of operation.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

Guo

Liu

Tang

et al. 2022

IJMS

View full text Add to dashboard Cite

The clinical use of anticancer drugs necessitates new technologies for their safe, sensitive, and selective detection. In this article, lanthanide (Eu3+ and Tb3+)-loaded γ-cyclodextrin nano-aggregates (ECA and TCA) are reported, which sensitively detects the anticancer drug irinotecan by fluorescence intensity changes. Fluorescent lanthanide (Eu3+ and Tb3+) complexes exhibit high fluorescence intensity, narrow and distinct emission bands, long fluorescence lifetime, and insensitivity to photobleaching. However, these lanthanide (Eu3+ and Tb3+) complexes are essentially hydrophobic, toxic, and non-biocompatible. Lanthanide (Eu3+ and Tb3+) complexes were loaded into naturally hydrophilic γ-cyclodextrin to form fluorescent nano-aggregates. The biological nontoxicity and cytocompatibility of ECA and TCA fluorescent nanoparticles were demonstrated by cytotoxicity experiments. The ECA and TCA fluorescence nanosensors can detect irinotecan selectively and sensitively through the change of fluorescence intensity, with detection limits of 6.80 μM and 2.89 μM, respectively. ECA can safely detect irinotecan in the cellular environment, while TCA can detect irinotecan intracellularly and is suitable for cell labeling.

show abstract

“…Because of the ever-increasing number of new medicinal substances, the problem of their identification and determination both in individual samples and in living organisms is relevant and timely. The need for the accumulation, generalization and systematization of data on the methods of control and analysis of medicinal substances has led to the emergence of specialized scientific publications [5][6][7][8][9][10][11][12][13]. Judging by the methods of analysis of medicinal substances based on the materials of the original articles, we can say that chromatographic methods of analysis are still in the lead.…”

Section: Introductionmentioning

confidence: 99%

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

et al. 2022

View full text Add to dashboard Cite

The technology for manufacturing a film membrane of the metamizole-selective electrode containing ion associate metamizole-octadecylammonium ODAH+MT− as an electrode active component (EAC) has been proposed. The main potentiometric characteristics of the metamizole-selective electrode have been determined. The expediency of the proposed design of the metamizole selective electrode for the determination of metamizole in dosage forms has been substantiated. The best composition of the membrane (wt.%) of the metamizole-selective electrode has corresponded to: ODAH+MT−—5.3; 2-nitrophenyloctylether—63.1; poly(vinyl chloride)—31.6. Electrode-active component in the membrane phase functions as an ion associate ODAH+MT−. Potentiometric characteristics of metamizole-selective electrode have been determined, which corresponded to: linear range 1 × 10−2–1 × 10−4 with limit of detection 4.58 × 10−5 M, electrode function slope −48.5 mV/dec., working interval pH 4.5–7.3, response time 60 s. The potentiometric coefficients of selectivity of the metamizole-selective electrode with respect to various ions have been determined. The possibility of determining metamizole in a medicinal product has been tested. The results of the analyses show good agreement between the two methods (relative error less than 7.0%) with coefficients of variation less than 5% for MT-SE and iodometric methods.

show abstract

A review on analytical methods with special reference to electroanalytical methods for the determination of some anticancer drugs in pharmaceutical and biological samples

Cited by 28 publications

References 208 publications

Cyclodextrins in the antiviral therapy

Cyclodextrins in the antiviral therapy

Lanthanide (Eu3+/Tb3+)-Loaded γ-Cyclodextrin Nano-Aggregates for Smart Sensing of the Anticancer Drug Irinotecan

The Ionic Associate of Metamizole as an Electrode-Active Component of a PVC Plasticized Membrane Electrode

Contact Info

Product

Resources

About