A Review on Bioactive Iridoids in Edible Fruits – from Garden to Food and Pharmaceutical Products

Przybylska, Dominika; Kucharska, Alicja Z.; Sozański, Tomasz

doi:10.1080/87559129.2022.2117375

Cited by 13 publications

(11 citation statements)

References 190 publications

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“…One of the raw materials of natural origin that can provide compounds that are potentially effective in the prevention and treatment of atherosclerosis is Cornelian cherry ( Cornus mas L.) fruits, which are rich in substances from the group of polyphenols, flavonoids, anthocyanins, and iridoids [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Compounds from these groups are widely known for their potential antioxidant and anti-inflammatory effects.…”

Section: Introductionmentioning

confidence: 99%

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model

Danielewski

Gomułkiewicz

Kucharska

et al. 2023

IJMS

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Atherogenesis leads to the development of atherosclerosis, a progressive chronic disease characterized by subendothelial lipoprotein retention and endothelial impairment in the arterial wall. It develops mainly as a result of inflammation and also many other complex processes, which arise from, among others, oxidation and adhesion. Cornelian cherry (Cornus mas L.) fruits are abundant in iridoids and anthocyanins—compounds with potent antioxidant and anti-inflammatory activity. This study aimed to determine the effect of two different doses (10 mg and 50 mg per kg of body weight, respectively) of iridoid and anthocyanin-rich resin-purified Cornelian cherry extract on the markers that are important in the progress of inflammation, cell proliferation and adhesion, immune system cell infiltration, and atherosclerotic lesion development in a cholesterol-rich diet rabbit model. We used biobank blood and liver samples that were collected during the previous original experiment. We assessed the mRNA expression of MMP-1, MMP-9, IL-6, NOX, and VCAM-1 in the aorta, and the serum levels of VCAM-1, ICAM-1, CRP, PON-1, MCP-1, and PCT. The application of the Cornelian cherry extract at a dose of 50 mg/kg bw resulted in a significant reduction in MMP-1, IL-6, and NOX mRNA expression in the aorta and a decrease in VCAM-1, ICAM-1, PON-1, and PCT serum levels. The administration of a 10 mg/kg bw dose caused a significant decrease in serum ICAM-1, PON-1, and MCP-1. The results indicate the potential usefulness of the Cornelian cherry extract in the prevention or treatment of atherogenesis-related cardiovascular diseases, such as atherosclerosis or metabolic syndrome.

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Section: Introductionmentioning

confidence: 99%

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model

Danielewski

Gomułkiewicz

Kucharska

et al. 2023

IJMS

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“…Iridoids, natural heterocyclic monoterpenoids, are secondary metabolites of herbal Flora and nautical fauna, which are widely distributed in herbs, medicinal and ornamental plants, particularly in their green parts. They have also found in some edible fruits, such as berries, noni, olive, Japanese cornel, haskap berry, kousa dogwood, cornelian cherry, and guelder rose [3]. Iridoids are found in a large number of plant families usually as glycosides [4].…”

Section: Introductionmentioning

confidence: 99%

“…Their presence has also been reported in insects. Iridodial is a substance which are produced by the Iridomyrmex detectus ants, the source from which the name 'iridoids' is derived [3,5].…”

Section: Introductionmentioning

confidence: 99%

“…As safe materials, they can be used in healthy diet, disease treatment and prevention, which showed signi cance properties such as antioxidative, antidiabetic, neuroprotective, anti-in ammatory, antiatherogenic, antihypertensive, anti-depression, cardioprotective, liver-protecting, anti-cancer, antimicrobial activity and etc [3,[5][6][7][8][9][10][11]. In addition, they have a listed application in cosmetic preparations [12].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, they have a listed application in cosmetic preparations [12]. Moreover, in vitro, in vivo, and clinical studies suggests they may help limit the aging and general tissue damage [3].…”

Section: Introductionmentioning

confidence: 99%

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Identification of two new acetylated Iridoids from Scrophularia umbrosa rhizome

Nikkhah,

Delazar,

Saadat

2024

Preprint

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Scrophularia umbrosa is a medicinal plant used as a traditional herb. This plant is one of the native species of Iran and consists of about 200 species of herbaceous flowering plants, commonly known as ‘figwort’. Many iridoid glycosides have been found in the Scrophularia genus. In this research work the methanolic extracts of Scrophularia umbrosa (S. umbrosa) rhizome was studied. For this first methanolic extract of rhizome powder was subjected to the HPLC in which two materials was detected in 220 nm and was separated. In continue 1D and 2D NMR technique has been employed for the identification of the active components. finally phytochemical investigations of the S. umbrosa rhizome indicate the presence of two new acetylated iridoid glycosides, 6- O [2', 3'diacyl-4'-O-Trans-cynamoyl]-α-L-rhamnopyranosyl-aucubin and 6- O [2', 3’ diacyl-4'-O-Trans-p-methoxycinamoyl]-α-L-rhamnopyranosyl-aucubin. HNMR and CNMR were the main apparatuse to identification of these compounds which has been shown medicinal property, in rhizome of Scrophularia umbrosa.

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Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential

Sobhy,

AbouZid,

Kirollos

et al. 2024

Chemistry & Biodiversity

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There is an increasing interest in using iridoids and secoiridoids as major targets for chemical synthesis and biosynthesis. Iridoids can be found in numerous species of Lamiaceae, Verbenaceae, Scrophulariaceae, and other families. Iridoids possess a chemical structure characterized by a cyclopentane ring with oxidative substituents, forming a six‐membered ring. Various research groups have used these structures as valuable starting materials for regioselective and stereoselective synthesis. This approach has enormous potential for the production of bioactive alkaloids, prostaglandin analogues, and other bioactive natural compounds. Because there is currently no review on lamiide and ipolamiide, this review intends to pique researchers' interest in this vital topic of natural science for drug discovery from naturally occurring iridoids. Lamiide and ipolamiide have the potential to be useful tools in the pharmaceutical sector, enabling the use of these plant metabolites in a variety of medicinal compositions. Given that these molecules appear to be potential natural substances for treating human ailments, we get light on them as alternative therapeutic approaches using these compounds alone or in combination with other substances which will potentially lead to future (pre)‐clinical investigations.

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A Review on Bioactive Iridoids in Edible Fruits – from Garden to Food and Pharmaceutical Products

Cited by 13 publications

References 190 publications

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model

Cornelian Cherry (Cornus mas L.) Iridoid and Anthocyanin-Rich Extract Reduces Various Oxidation, Inflammation, and Adhesion Markers in a Cholesterol-Rich Diet Rabbit Model

Identification of two new acetylated Iridoids from Scrophularia umbrosa rhizome

Lamiide and Ipolamiide: A Comprehensive Review of Their Bioactive Properties and Therapeutic Potential

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