A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid

Mohamadi, Neda; Sharififar, Fariba; Pournamdari, Mostafa; Ansari, Mehdi

doi:10.1080/19390211.2017.1329244

Cited by 95 publications

(56 citation statements)

References 72 publications

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“…Furthermore, many common foods contain TGN such as barley, cantaloupes, corn, onions, soybeans, peas, and tomatoes 4 . Numerous reports on the biological activity of TGN have mentioned its role in protecting the liver and heart and in the treatment of hypercholesterolaemia, hyperglycaemia, and central nervous system disorders 5 . Only one report has suggested the potential role of TGN as an anti-Alzheimer’s drug.…”

Section: Introductionmentioning

confidence: 99%

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Farid

Yang

Kuboyama

et al. 2020

Sci Rep

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Trigonelline (TGN; 1-methylpyridin-1-ium-3-carboxylate) is a widely distributed alkaloid derived from plants. Since we previously found a neurite outgrowth effect of TGN, we hypothesised that TGN might help to improve memory deficits. Here, the efficacy of TGN in restoring amyloid β (Aβ)-induced axonal degeneration and in improving memory function was investigated in Alzheimer’s disease 5XFAD model mice that overexpress mutated APP and PS1 genes. Exposure of Aβ25-35 for 3 days induced atrophy of axons and dendrites. Post treatment of TGN recovered the lengths of axons and dendrites. Following oral administration of TGN in mice, TGN itself was detected in the plasma and cerebral cortex. Oral administration of TGN to 5XFAD mice for 14 days showed significant improvement in object recognition memory (P < 0.001) and object location memory (P < 0.01). TGN administration also normalised neurofilament light levels in the cerebral cortex (P < 0.05), which is an axonal damage-associated biomarker. Analysis of target proteins of TGN in neurons by a drug affinity responsive target stability (DARTS) method identified that creatine kinase B-type (CKB) is a direct binding protein of TGN. Treatment with a CKB inhibitor cancelled the TGN-induced axonal and dendritic growth. In conclusion, we found for the first time that TGN penetrates the brain and may activate CKB, leading to axonal formation. This study shows the potential of TGN as a new drug candidate, and a new target molecule, CKB, in memory recovery signalling.

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Section: Introductionmentioning

confidence: 99%

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Farid

Yang

Kuboyama

et al. 2020

Sci Rep

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“…These molecules have been selected because they are among the most attractive active molecules contained in the SCG for cosmetic purposes. In particular, caffeic acid is very well known as an antioxidant with free radical scavenging properties [16], while trigonelline is beneficial for its antimicrobial properties, and thus it could aid in preventing the microbial contamination of the extracts and cosmetic formulations [17]. Niacinamide possesses a stabilizing effect on epidermal barrier function, reducing the trans epidermal water loss and thus favoring the skin hydration.…”

Section: Introductionmentioning

confidence: 99%

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

et al. 2020

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The purpose of this work was the optimization of the extraction from spent coffee grounds, specifically 100% Arabica coffee blends, using a desirability approach. Spent coffees were recovered after the preparation of the espresso coffee under the typical conditions used in coffee bars with a professional machine. Spent coffee was subjected to different extraction procedures in water: by changing the extraction temperature (60, 80, or 100 °C) and the solvent extraction volume (10, 20, 30 mL for 1 g of coffee) and by maintaining constant the extraction time (30 min). The ranges of the process parameters, as well as the solvent to be used, were established by running preliminary experiments not reported here. The variables of interest for the experimental screening design were the content of caffeine, trigonelline, and nicotinic acid, quantitatively determined from regression lines of standard solutions of known concentrations by a validated HPLC-VWD method. Since solvent extraction volumes and temperatures were revealed to be the most significant process variables, for the optimization of the extraction process, an approach based on Response Surface Methodology (RSM) was considered. In particular, a Box-Wilson Central Composite Design, commonly named central composite design (CCD), was used to find the optimal conditions of the extraction process. Moreover, the desirability approach was then applied to maximize the extraction efficiency by searching the optimal values (or at least the best compromise solution) for all three response variables simultaneously. Successively, the best extract, obtained in a volume of 20 mL of water at an extraction temperature of 80 °C, was analyzed for total phenol content (TPC) through the Folin–Ciocalteu assay, and the antioxidant capacities (AC) through the trolox equivalent (TE) antioxidant capacity (DPPH), ferric-ion reducing antioxidant parameter (FRAP), and radical cation scavenging activity and reducing power (ABTS). The TPC and the AC for spent coffee were high and comparable to the results obtained in previous similar studies. Then, the extract was evaluated by inductively coupled plasma mass spectrometry (ICP–MS), revealing that potassium was the most abundant element, followed by phosphorus, magnesium, calcium, sodium, and sulfur, while very low content in heavy metals was observed. Preliminary in vitro assays in keratinocyte HaCaT cells were carried out to assess the safety, in terms of cytotoxicity of spent coffee, and results showed that cell viability depends on the extract concentration: cell viability is unmodified up to a concentration of 0.3 mg/mL, over which it becomes cytotoxic for the cells. Spent coffee extract at 0.03 and 0.3 mg/mL showed the ability to reduce intracellular reactive oxygen species formation induced by hydrogen peroxide in HaCaT cells, suggesting its antioxidant activity at intracellular levels.

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“…With an HPLC-florescence detector, aspartic acid has been found to be the main content along with arginine as a minor content. Trigonelline performs many biological activities that affect the brain, including but not limited to antinociception, the stimulation of dopamine release, and inhibition of the γ-aminobutyric acid (GABA) receptor response [ 37 ]. In addition, previous studies revealed that DL also contains amino acids such as arginine and aspartic acid [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model

et al. 2018

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Irritable bowel syndrome (IBS) is a common gastrointestinal disorder manifesting as unexplained abdominal pain and bowel habit changes. The pathogenesis of post-infectious IBS is associated with gut–brain axis dysfunction, including low-grade colonic inflammation and anxiety-related long-term brain changes. This study analyzed the efficacy of a standardized extract of Dolichos lablab L. extract (DL), a bean species, in an IBS mouse model resembling post-infectious, diarrhea-dominant IBS. Using a zymosan-induced animal IBS model, we found that oral administration of DL significantly attenuated zymosan-induced increases in colonic macroscopic scores and minimized weight loss without affecting food intake. In the DL-treated mice, the mast cell count and tumor necrosis factor-α level in the colon markedly decreased, similar to results in sulfasalazine-treated mice and in mice with lipopolysaccharide-stimulated bone marrow-derived mast cells. The number of visceral pain-related behaviors was much lower in the DL-treated mice. Anxiety-like behaviors significantly improved, comparable to that after treatment with amitriptyline. The c-Fos expression level in the prefrontal cortex was significantly reduced. Our data suggest that DL could be beneficial for treating IBS by acting on the gut and brain.

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A Review on Biosynthesis, Analytical Techniques, and Pharmacological Activities of Trigonelline as a Plant Alkaloid

Cited by 95 publications

References 72 publications

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Optimization of the Extraction from Spent Coffee Grounds Using the Desirability Approach

Alleviation of Irritable Bowel Syndrome-Like Symptoms and Control of Gut and Brain Responses with Oral Administration of Dolichos lablab L. in a Mouse Model

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