A review on borate bioactive glasses (BBG): effect of doping elements, degradation, and applications

Abodunrin, Oluwatosin David; Mabrouk, Khalil El; Bricha, Meriame

doi:10.1039/d2tb02505a

Cited by 39 publications

(14 citation statements)

References 209 publications

(283 reference statements)

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“…BG composition and morphological characteristics affect network connectivity and dissolution rate/solubility. Ions present within a BG matrix are characterized as either network formers, network modifiers or intermediate oxides, as shown in Figure . , Silica, phosphorus pentoxide, and boron trioxide are the most common network formers. , These compounds can form glass networks on their own, without additional products . Network modifier ions alter the glass network structure created by network formers by bonding to nonbridging oxygen atoms .…”

Section: Discussionmentioning

confidence: 99%

“…For example, 45S5 Bioglass is a quaternary BG: SiO 2 (45 wt %), Na 2 O (24.5 wt %), CaO (24.5 wt %), and P 2 O 5 (6 wt %). ,,− However, binary BGs are also possible, for example 70S30C which contains two constituents: 70 mol % SiO 2 and 30 mol % CaO. , While Si-based BGs were traditionally most common, phosphate- and borate-based BGs have recently emerged in soft tissue applications . Phosphate- and borate-based BGs have been preferred for the faster rate at which the network dissolves in biological environments, due to having lower chemical stability and network connectivity compared to silica-BGs. ,,,− An important goal for developing BGs in soft tissue applications, is the rapid yet controlled release of biologically active ions into the physiological environment to induce an adequate tissue regenerative/wound healing response …”

Section: Discussionmentioning

confidence: 99%

“…The use of borate (BO 3 ) as the main network former in skin wound healing BGs has increased, as it results in faster matrix degradation rate, more rapid BG-tissue interface formation and earlier delivery of therapeutically active ions. ,,,,,,,, Similar to Si-based BGs, BO 3 -based BGs are commonly formulated for skin wound healing and some have FDA approval for such applications. Abodunrin; El Mabrouk and Bricha reviewed borate-based BGs and their applications. Stone-Weiss; Bradtmüller; Eckert; et al published an overview of soft tissue-specific design of borosilicate and borate-based BGs.…”

Section: Discussionmentioning

confidence: 99%

“…1,4 Silica, phosphorus pentoxide, and boron trioxide are the most common network formers. 1,15 These compounds can form glass networks on their own, without additional products. 4 Network modifier ions alter the glass network structure created by network formers by bonding to nonbridging oxygen atoms.…”

Section: Literature Search Methodologymentioning

confidence: 99%

See 3 more Smart Citations

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Harrop,

Tupally,

Pandey

et al. 2023

Mol. Pharmaceutics

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Bioactive glasses (BGs) are widely used in orthopedic and dental applications for their ability to stimulate endogenous bone formation and regeneration. BG applications more recently broadened to include soft tissue conditions, based on their ability to stimulate angiogenesis, soft tissue regeneration, and wound healing. Sol−gel synthesis has helped facilitate this expansion, allowing formulators to tailor the morphological characteristics of the BG matrix. The effectiveness of BGs in skin wound healing is viewed as a gateway for their use as both a therapeutic and drug delivery platform in other soft tissue applications, notably gastrointestinal (GI) applications, which form the focus of this review. Recent changes in international guidelines for GI conditions shifted clinical objectives from symptom management to mucosal wound healing. The additional scrutiny of proton pump inhibitor (PPI) safety, increasing burden of disease, and financial costs associated with gastroesophageal reflux disease (GERD), peptic ulcer disease (PUD), and inflammatory bowel disease (IBD) open new clinical possibilities for BG. This narrative literature review intersects materials engineering, formulation science, and clinical practice, setting it apart from prior literature. Broadly, current evidence for BG applications in GI conditions is sparse and under-developed, which this review directly addresses. It explores and synthesizes evidence that supports the potential use of sol− gel-derived BG for the efficacious treatment of soft tissue applications, with specific reference to GI conditions. An overview with comparative analysis of current BG synthesis techniques and associated challenges is presented, and influences of composition, biologically active ions, and morphological characteristics in soft tissue applications are explored. To contextualize this, sol−gelderived BGs are proposed as a dual, tailorable therapeutic and drug delivery platform for upper and lower GI conditions. Future directions for this largely untapped area of translational research are also proposed, based on extant literature.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Literature Search Methodologymentioning

confidence: 99%

See 2 more Smart Citations

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Harrop,

Tupally,

Pandey

et al. 2023

Mol. Pharmaceutics

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“…Borate-based glass utilizes boron as its primary network-forming element. In the human body, boron is an element present in the trace range of 3–20 mg . When compared to other glasses borate glass converts to hydroxyapatite (HAP) more quickly in the biological environment .…”

Section: Introductionmentioning

confidence: 99%

Investigation of Osteomyelitis Inducing Methicillin-Resistant Staphylococcus aureus Inhibition Effect by Strontium-Substituted Borate Bioactive Glasses

Mohan,

Ravindran,

Marudhamuthu

et al. 2024

ACS Appl. Bio Mater.

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Borate glass transforms into hydroxycarbonate apatite more rapidly than silicate glass. This research aims to evaluate strontium's structural and biological effects on borate bioactive glass (BBG) and the influence of strontium concentrations (0%, 5%, 10%, and 15% Sr) prepared via the sol−gel method. The study reveals significant findings related to the physicochemical properties of the glass. Immersion of the glass powders in a simulated body fluid (SBF) led to the development of a hydroxyapatite (HAP) layer on the glass surfaces. This transformation was verified through X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) analyses. In particular, 5% strontium exhibited gradual degradation, resulting in particle sizes below 100 nm. The BBG-15% Sr demonstrates heightened pathogenic activity as it shows a significant inhibition zone of 14 mm at 250 μg/mL, surpassing other substituted BBGs. It effectively combats Gram-positive bacteria, completely inhibiting MRSA growth at 50 μg/mL. This underscores its robust biofilm disruption capabilities, eradicating biofilms, even at minimal concentrations after prolonged exposure. C. elegans when subjected to BBG-15%Sr shows less ROS production when compared with the others. Moreover, the results suggest that the modified glass could be a potential material for the treatment of osteomyelitis-affected bone repair.

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Introduction

Thapliyal,

Tewari,

Verma

et al. 2024

Functional Coatings for Biomedical, Energy, and Environmental Applications

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A review on borate bioactive glasses (BBG): effect of doping elements, degradation, and applications

Abstract: Because of their excellent biologically active qualities, bioactive glasses (BGs) have been extensively used in the biomedical domain, leading to better tissue–implant interactions and promoting bone regeneration and wound healing....

Cited by 39 publications

References 209 publications

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Opportunities for Bioactive Glass in Gastrointestinal Conditions: A Review of Production Methodologies, Morphology, Composition, and Performance

Investigation of Osteomyelitis Inducing Methicillin-Resistant Staphylococcus aureus Inhibition Effect by Strontium-Substituted Borate Bioactive Glasses

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