A review on bovine hydroxyapatite; extraction and characterization

Moradi, Ali; Pakizeh, Majid; Ghassemi, Toktam

doi:10.1088/2057-1976/ac414e

Cited by 9 publications

(6 citation statements)

References 212 publications

(265 reference statements)

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“…The XRD profiles of the mineralized hydrogels supplemented with TDM and nHA were largely similar to that of the added mineral matrix. The diffraction peaks of nHA and TDM at 2θ were 25.7°, 28.6°, 31.5°, 34.2°, 40.1°, 47.1°, 49.8°, and 53.2°, which are consistent with the values specified in the XRD standard card of HA (JCPDS: 72-1243) 46 .…”

Section: Physicochemical Characterization Of Mineralized Hydrogelsupporting

confidence: 84%

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

et al. 2023

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Maxillofacial hard tissue defects caused by trauma or infection often affect craniofacial function. Taking the natural hard tissue structure as a template, constructing an engineered tissue repair module is an important scheme to realize the functional regeneration and repair of maxillofacial hard tissue. Here, inspired by the biomineralization process, we constructed a composite mineral matrix hydrogel PAA-CMC-TDM containing amorphous calcium phosphates (ACPs), polyacrylic acid (PAA), carboxymethyl chitosan (CMC) and dentin matrix (TDM). The dynamic network composed of Ca2+·COO− coordination and ACPs made the hydrogel loaded with TDM, and exhibited self-repairing ability and injectability. The mechanical properties of PAA-CMC-TDM can be regulated, but the functional activity of TDM remains unaffected. Cytological studies and animal models of hard tissue defects show that the hydrogel can promote the odontogenesis or osteogenic differentiation of mesenchymal stem cells, adapt to irregular hard tissue defects, and promote in situ regeneration of defective tooth and bone tissues. In summary, this paper shows that the injectable TDM hydrogel based on biomimetic mineralization theory can induce hard tissue formation and promote dentin/bone regeneration.

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Section: Physicochemical Characterization Of Mineralized Hydrogelsupporting

confidence: 84%

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

et al. 2023

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“…More specifically, the characteristic absorptions bands of the υ2 (PO4 3− ) and OH − groups are observed at 474 cm −1 , the υ4 (PO4 3− ) at 570 and 602 cm −1 , υ1 (PO4 3− ) at 962 cm −1 , and υ3 (PO4 3− ) at 1051 and 1092 cm −1 . The band at 633 cm −1 is attributed to the OH-groups and can be considered proof of the presence of HA [45][46][47]. The intensity of this band does not change with the increasing amount of MgO, which indicates that Mg does not enter the HA structure [48].…”

Section: Resultsmentioning

confidence: 99%

An Eco-Friendly Process to Extract Hydroxyapatite from Sheep Bones for Regenerative Medicine: Structural, Morphologic and Electrical Studies

Gavinho,

Bozdag,

Kalkandelen

et al. 2023

JFB

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Hydroxyapatite (HA) promotes excellent bone regeneration in bone-tissue engineering, due to its similarity to bone mineral and its ability to connect to living tissues. These factors promote the osteointegration process. This process can be enhanced by the presence of electrical charges, stored in the HA. Furthermore, several ions can be added to the HA structure to promote specific biological responses, such as magnesium ions. The main objective of this work was to extract hydroxyapatite from sheep femur bones and to study their structural and electrical properties by adding different amounts of magnesium oxide. The thermal and structural characterizations were performed using DTA, XRD, density, Raman spectroscopy and FTIR analysis. The morphology was studied using SEM, and the electrical measurements were registered as a function of frequency and temperature. Results show that: (i) an increase of MgO amount indicates that the solubility of MgO is below 5%wt for heat treatments at 600 °C; (ii) the rise of MgO content increases the capacity for electrical charge storage; (iii) sheep hydroxyapatite presents itself as a natural source of hydroxyapatite, environmentally sustainable and low cost, and promising for applications in regenerative medicine.

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“…In addition, based on the results of this study, it may be possible to enhance the bone regeneration of the hydrogel by doping different components in future research. Hydroxyapatite (HAP), for example, is the important inorganic component of human bone tissue [33,34]. It can dissolve and release some harmless ions in the body and can participate in metabolism in the body.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal Stem Cells–Hydrogel Microspheres System for Bone Regeneration in Calvarial Defects

Teng

Tong

et al. 2022

Gels

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The repair of large bone defects in clinic is a challenge and urgently needs to be solved. Tissue engineering is a promising therapeutic strategy for bone defect repair. In this study, hydrogel microspheres (HMs) were fabricated to act as carriers for bone marrow mesenchymal stem cells (BMSCs) to adhere and proliferate. The HMs were produced by a microfluidic system based on light-induced gelatin of gelatin methacrylate (GelMA). The HMs were demonstrated to be biocompatible and non-cytotoxic to stem cells. More importantly, the HMs promoted the osteogenic differentiation of stem cells. In vivo, the ability of bone regeneration was studied by way of implanting a BMSC/HM system in the cranial defect of rats for 8 weeks. The results confirmed that the BMSC/HM system can induce superior bone regeneration compared with both the HMs alone group and the untreated control group. This study provides a simple and effective research idea for bone defect repair, and the subsequent optimization study of HMs will provide a carrier material with application prospects for tissue engineering in the future.

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A review on bovine hydroxyapatite; extraction and characterization

Cited by 9 publications

References 212 publications

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

Biomineralization-inspired mineralized hydrogel promotes the repair and regeneration of dentin/bone hard tissue

An Eco-Friendly Process to Extract Hydroxyapatite from Sheep Bones for Regenerative Medicine: Structural, Morphologic and Electrical Studies

Mesenchymal Stem Cells–Hydrogel Microspheres System for Bone Regeneration in Calvarial Defects

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