A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment

Lee, Joanna Jinling; Yazan, Latifah Saiful; Abdullah, Che Azurahanim Che

doi:10.2147/ijn.s127329

Cited by 83 publications

(59 citation statements)

References 84 publications

(65 reference statements)

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“…Several approaches have been investigated with regard to possible ways to improve cancer therapy. In the last decade, the most important archetype improvement in drug carriage was heralded by the use of nanomaterials (De Jong and Borm, 2008;Lee et al, 2017). Nanotechnology offers a variety of possibilities, including enhancement of drug delivery, facilitation of diagnostics, bioimaging, active implants, and direct therapeutic effects (Nune et al, 2009;Tomisa et al, 2011;Kadam et al, 2012;Laroui et al, 2013;Gmeiner and Ghosh, 2015).…”

Section: Introductionmentioning

confidence: 99%

Ti_0.8O₂Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

et al. 2019

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Recent research into the cancer stem cell (CSC) concept has driven progress in the understanding of cancer biology and has revealed promising CSC-specific targets for drug discovery efforts. As malignancies of lung cancer have been shown to be strongly associated with activities of CSCs, we examined the effects of Ti 0.8 O 2 nanosheets on these cells. Here we show that the nanosheets target lung CSCs but not normal primary dermal papilla (DP) stem cells. Whereas Ti 0.8 O 2 caused a dramatic apoptosis along with a decrease in CSC phenotypes, in primary human DP cells such effects of nanosheets have been minimal. Nanosheets reduced the ability of lung cancer cells to generate three-dimensional tumor spheroids, lung CSC markers (CD133 and ALDH1A1), and CSC transcription factors (Nanog and Oct-4). Ti 0.8 O 2 nanosheets reduced CSC signaling through mechanisms involving suppression of protein kinase B (AKT) and Notch-1 pathways. In addition, the nanosheets inhibited the migration and invasive activities of lung cancer cells and reduced epithelial-to-mesenchymal transition (EMT) markers as N-cadherin, vimentin, and Slug, as well as metastasis-related integrins (integrin-av and integrin-b1). Importantly, we found that the selectivity of the Ti 0.8 O 2 nanosheets in targeting cancer cells was mediated by induction of cellular superoxide anion in cancerous but not normal cells. Inhibition of nanosheet-induced superoxide anion restored the suppression of CSC and EMT in cancer cells. These findings demonstrate a promising distinctive effect of Ti 0.8 O 2 nanosheets on lung CSC that may lead to opportunities to use such a nanomaterial in cancer therapy.

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Section: Introductionmentioning

confidence: 99%

Ti_0.8O₂Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

et al. 2019

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“…Carbon nanotubes (CNTs), which are one of the most widely researched carbon nanomaterials for cancer therapy, have been reported to enhance the efficacy of cancer drugs such as doxorubicin by suppressing the drug’s toxic side effects and by bypassing chemoresistance. Despite these advantages, CNTs can induce undesirable cytotoxic side effects, and the lack of long-term studies on their toxicity in humans has prevented the study of this nanocarrier in the clinical setting [100]. However, a number of clinical studies have been conducted with more biocompatible carbon nanomaterials for cancer therapy, such as activated carbon nanoparticles, which were evaluated as nanocarriers for methotrexate in a 1996 clinical study for the treatment of gastric and esophageal cancers [101].…”

Section: Delivery Of Therapeuticsmentioning

confidence: 99%

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Whitlow

Pacelli

Paul

2017

Journal of Controlled Release

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With recent advances in the field of nanomedicine, many new strategies have emerged for diagnosing and treating diseases. At the forefront of this multidisciplinary research, carbon nanomaterials have demonstrated unprecedented potential for a variety of regenerative medicine applications including novel drug delivery platforms that facilitate the localized and sustained release of therapeutics. Nanodiamonds (NDs) are a unique class of carbon nanoparticles that are gaining increasing attention for their biocompatibility, highly functional surfaces, optical properties, and robust physical properties. Their remarkable properties have established NDs as an invaluable regenerative medicine platform, with a broad range of clinically relevant applications ranging from targeted delivery systems for insoluble drugs, bioactive substrates for stem cells, and fluorescent probes for long-term tracking of cells and biomolecules in vitro and in vivo. This review introduces the synthesis techniques and the various routes of surface functionalization that allow for precise control over the properties of NDs. It also provides an in-depth overview of the current progress made towards the use of NDs in the fields of drug delivery, tissue engineering, and bioimaging. Their future outlook in regenerative medicine including the current clinical significance of NDs, as well as the challenges that must be overcome to successfully translate the reviewed technologies from research platforms to clinical therapies will also be discussed.

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“…Качественный анализ взаимодействия проводили путем измерения оптической плотности суспензий на спектрофотометре Экрос ПЭ-5400ВИ на длине волны 315 нм, соответствующей максимум поглощения «Амоксициллина». Полученные изотермы соответствуют адсорбции типа IV, ассоциирующейся с капиллярной конденсацией в мезопорах, что являются одними из определяющих характеристик загрузочной способности НП в качестве системы доставки [10], поэтому для дальнейших экспериментов использовался образец с концентрацией допанта 3 %, имеющий максимальные размер и объем пор.…”

Section: Siounclassified

Properties Evaluation of Mesoporous Silica Nanopowders Doped With Manganese Dioxide Produced by a Pulsed Electron Beam Evaporation for Biomedical Applications

Zlygosteva¹,

Sokovnin²,

Il’ves³

2017

pcascnn

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A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment

Cited by 83 publications

References 84 publications

Ti_0.8O₂Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

Ti_0.8O₂Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Properties Evaluation of Mesoporous Silica Nanopowders Doped With Manganese Dioxide Produced by a Pulsed Electron Beam Evaporation for Biomedical Applications

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A review on current nanomaterials and their drug conjugate for targeted breast cancer treatment

Cited by 83 publications

References 84 publications

Ti0.8O2Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

Ti0.8O2Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

Multifunctional nanodiamonds in regenerative medicine: Recent advances and future directions

Properties Evaluation of Mesoporous Silica Nanopowders Doped With Manganese Dioxide Produced by a Pulsed Electron Beam Evaporation for Biomedical Applications

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Product

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Ti_0.8O₂Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion

Ti_0.8O₂Nanosheets Inhibit Lung Cancer Stem Cells by Inducing Production of Superoxide Anion