A review on fabrication, actuation, and application of magnetic force driven, light driven and DNA nano/microrobots in modern theranostics

Pogu, Sunil Venkanna; Dehariya, Dheeraj; Yadav, Dokkari Nagalaxmi; Rengan, Aravind Kumar

doi:10.1039/d2me00247g

Cited by 6 publications

(7 citation statements)

References 113 publications

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“…This top-down origami approach is a simple yet powerful technique in the field of DNA nanotechnology. Initiated by origami techniques, various DNA structures have been elaborately fabricated, including DNA nanonetworks (Figure 2D), 45 DNA nanocapsules (Figure 2E), 46 DNA nanorobots (Figure 2F), 47 non-periodic 2D structures, 48 3D DNA structures (octahedron structures, tetrahedra DNA structures, etc. ), 42,49,50 structures with complex curvatures, 51 and dynamic DNA structures.…”

Section: Design and Assembly Of Dna Nanostructuresmentioning

confidence: 99%

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Advances of fluorescent DNA nanostructures in biomedical applications

Shen,

Cao,

Xing

et al. 2024

TIMS

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With the rapid development of DNA nanotechnology, the emergence of fluorescent DNA nanostructures (FDNs) has enlarged the biological applications. FDNs have great advantages of precise localization and real-time tracing in bioimaging. In this review, the recent biomedical developments of FDNs have been reviewed, including the design of FDNs, and the corresponding applications on biomarker sensing, bioimaging, cancer diagnosis and therapy. Firstly, the development of DNA nanostructures and the corresponding DNA-based nanomaterials were briefly introduced. Simultaneously, to make a better demonstration, the background and theory of the fluorescence detections were briefly introduced. Thereafter, the synthetic strategies of DNA nanostructure were summarized and classified, which facilitated the multiple functionalizations for sensing and bioimaging. Subsequently, the biomedical applications of FDNs are comprehensively summarized based on different detection strategies, including fluorescence resonance energy transfer (FRET), aggregation-induced emission (AIE), near-infrared (NIR)-photoactivation, nucleic acid amplification (NAT), small fluorescent dyes loading, and surface plasmon resonance (SPR) technologies. Finally, an insight into the challenges and future perspectives is provided. As reviewed, FDNs are important tools in precision medicine, showing great potential in both in vivo and in vitro cancer diagnosis and treatments. Undoubtedly, FDN-based technology is a promising strategy for constructing versatile nanodevices in biological applications and will excel in human healthcare.

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Section: Design and Assembly Of Dna Nanostructuresmentioning

confidence: 99%

Section: Fluorescence Resonance Energy Transfer (Fret)-based Dna Nano...mentioning

confidence: 99%

Advances of fluorescent DNA nanostructures in biomedical applications

Shen,

Cao,

Xing

et al. 2024

TIMS

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“…Unfortunately, the use of such treatment modalities is limited due to their adverse side effects such as higher toxic offtargeted effects on the body and the development of drug resistance. 2,3 According to recent research, utilizing combined treatment modalities will result in minimal side effects and greater efficacy than utilizing a single therapy. 4 Nanotechnology is used in various biomedical applications due to its excellent physicochemical and targeting properties.…”

Section: Introductionmentioning

confidence: 99%

“…Despite its advantages, chemotherapy is limited in solid tumors because of its penetration depth and poor targeting ability. Unfortunately, the use of such treatment modalities is limited due to their adverse side effects such as higher toxic off-targeted effects on the body and the development of drug resistance. , …”

Section: Introductionmentioning

confidence: 99%

Advances in Peptide-Decorated Targeted Drug Delivery: Exploring Therapeutic Potential and Nanocarrier Strategies

Buddhiraju,

Yadav,

Dey

et al. 2023

ACS Appl. Bio Mater.

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Peptides are ideal biologicals for targeted drug delivery and have also been increasingly employed as theranostic tools in treating various diseases, including cancer, with minimal or no side effects. Owing to their receptor-specificity, peptidemediated drug delivery aids in targeted drug delivery with better pharmacological biodistribution. Nanostructured self-assembled peptides and peptide−drug conjugates demonstrate enhanced stability and performance and captivating biological effects in comparison with conventional peptides. Moreover, they serve as valuable tools for establishing interfaces between drug carriers and biological systems, enabling the traversal of multiple biological barriers encountered by peptide−drug conjugates on their journeys to their intended targets. Peptide-based drugs play a pivotal role in the field of medicine and hold great promise for addressing a wide range of complex diseases such as cancer and autoimmune disorders. Nanotechnology has revolutionized the fields of medicine, biomedical engineering, biotechnology, and engineering sciences over the past two decades. With the help of nanotechnology, better delivery of peptides to the target site could be achieved by exploiting the small size, increased surface area, and passive targeting ability of the nanocarrier. Furthermore, nanocarriers also ensure safe delivery of the peptide moieties to the target site, protecting them from degradation. Nanobased peptide delivery systems would be of significant importance in the near future for the successful targeted and efficient delivery of peptides. This review focuses on peptide−drug conjugates and nanoparticle-mediated self-assembled peptide delivery systems in cancer therapeutics.

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“…Our findings will impact not only the microswimmer field but also the emerging field of nanoscale swimming robots that can use DNA nanotechnology in conjunction with other nanoscale materials such as spherical particles. 16,17 We note that fabrication and optimization of DNA-based nanoswimmers could open a new realm of possibilities for interacting with nanoscale environments.…”

Section: Introductionmentioning

confidence: 99%