A review on fast dissolving tablet

Abstract

These tablets are distinguished from conventional sublingual tablets, lozenges, and buccal tablets which require more than a minute to dissolve in the mouth. In the literature, ODTs also are called orally disintegrating, orodisperse, mouth-dissolving, quick-dissolve, fast-melt, and rapid-disintegrating tablets. Over the past three decades, orally disintegrating tablets (ODTs) have gained much attention as a preferred alternative to conventional oral dosage forms such as tablets and capsules. An ODT is a solid dosage form that disintegrates and dissolves in the mouth (either on or beneath the tongue or in the buccal cavity) without water within 60 seconds or less. The desire of improved palatability in orally administered products has prompted the development of numerous formulations with improved performance and acceptability, and the field has become a rapidly growing area in the pharmaceutical industry. The unique property of mouth dissolving tablet is that they are rapidly disintegrating and/or dissolving and release the drug as soon as they come in contact with saliva, thus obviate the requirement of water during administration. This article reviews the earlier applications and methodologies of taste masking and also emphasize on the recent developments and approaches of bitterness reduction for orally used pharmaceuticals. Apart from the conventional methods of fabrication, this review also provides the detailed concept of some unique patents; technologies developed and marketed formulations of Mouth Dissolving Tablets (MDTs).

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“…This binder possesses dual action by increasing physical strength, it also increases disintegration. The characteristics of compaction method is that it rapidly melts in the mouth, thus, leaving no residue 15 .…”

Review of Fast-dissolving Tablets - A New Era in Brand-new Drug Delivery Systems

“…Fast dissolving tablets are taken by the pregastric area, such as the throat and oesophagus, resulting in a rapid commencement of action [5,6]. This could result in higher bioavailability of active pharmacological drugs by dose reduction and clinical effectiveness with a reduced risk of side effects [7].…”

Development and Evaluation of Fast Dissolving Liquisolid Haloperidol Tablets

“…Pre compression tests Table (4) shows that all prepared formulas have good angle of repose, Carrʼs index %, Hausner ratio, void volume and porosity compared to pure drug, so all prepared formulas were then compressed and tested for post compression test. FTIR of tween 20 (80%) showed in Fig.…”

“…Salt formation, solubilization, particle size reduction have been used to increase dissolution rate, and thereby oral absorption and bioavailability of low water soluble drugs. Liquisolid technique has been utilized as effective strategy to improve the dissolution and bioavailability of poorly watersoluble drugs [4]. Haloperidol belongs to a class of drugs called Antipsychotics, 1 st generation CYP3A4 inhibitor, prescribed to treat the symptoms of schizophrenia and psychosis.…”