A Review on Green Synthesis of Zinc Oxide Nanoparticles Using Plant Extracts and Its Biomedical Applications

Akintelu, Sunday Adewale; Folorunso, Aderonke Similoluwa

doi:10.1007/s12668-020-00774-6

Cited by 147 publications

(66 citation statements)

References 131 publications

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“…ZnO NPs are one of the most widely used metal oxide NPs in a variety of sectors and research institutions since they possess significant applications [ 43 ]. Because of the small particle size of nano-ZnO, the human body can easily absorb zinc.…”

Section: Zinc Oxide Nanoparticles (Zno Nps): Potential Candidate For Fighting Cancermentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anjum

Hashim

Malik

et al. 2021

Cancers

281

102

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Cancer is regarded as one of the most deadly and mirthless diseases and it develops due to the uncontrolled proliferation of cells. To date, varieties of traditional medications and chemotherapies have been utilized to fight tumors. However, their immense drawbacks, such as reduced bioavailability, insufficient supply, and significant adverse effects, make their use limited. Nanotechnology has evolved rapidly in recent years and offers a wide spectrum of applications in the healthcare sectors. Nanoscale materials offer strong potential for curing cancer as they pose low risk and fewer complications. Several metal oxide NPs are being developed to diagnose or treat malignancies, but zinc oxide nanoparticles (ZnO NPs) have remarkably demonstrated their potential in the diagnosis and treatment of various types of cancers due to their biocompatibility, biodegradability, and unique physico-chemical attributes. ZnO NPs showed cancer cell specific toxicity via generation of reactive oxygen species and destruction of mitochondrial membrane potential, which leads to the activation of caspase cascades followed by apoptosis of cancerous cells. ZnO NPs have also been used as an effective carrier for targeted and sustained delivery of various plant bioactive and chemotherapeutic anticancerous drugs into tumor cells. In this review, at first we have discussed the role of ZnO NPs in diagnosis and bio-imaging of cancer cells. Secondly, we have extensively reviewed the capability of ZnO NPs as carriers of anticancerous drugs for targeted drug delivery into tumor cells, with a special focus on surface functionalization, drug-loading mechanism, and stimuli-responsive controlled release of drugs. Finally, we have critically discussed the anticancerous activity of ZnO NPs on different types of cancers along with their mode of actions. Furthermore, this review also highlights the limitations and future prospects of ZnO NPs in cancer theranostic.

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Section: Zinc Oxide Nanoparticles (Zno Nps): Potential Candidate For Fighting Cancermentioning

confidence: 99%

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Anjum

Hashim

Malik

et al. 2021

Cancers

281

102

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“…From the IR compared to that of the citrus peel, it is obvious that the functional group responsible for the three desired roles of bioreduction, capping and stabilization by electron donation, corresponds to that of flavonoids, proteins, esters, soluble sugars, carboxylic acid from phenolic acids, alcohol and carbonyl groups. A typical IR absorption bands for the OPE and LPE mediated NPs showed common strong peaks at 493 cm −1 for all CuONPs/CPE, typical of Cu-O stretching vibration [ 55 , 56 ] and diversified band of, 620 cm −1 for ZnO NPs of both BiONPs, 622 and 627 cm −1 for the, ZnO/LPE and ZnO/OPE, respectively, which is typical to that of ZnO band [ 57 , 58 , 59 ].…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Characterization and Detection of Lead in Water Using SPCE Modified with BiONPs/PANI

et al. 2021

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The need for constant assessment of river water qualities for both aquatic and other biological survival has emerged a top priority, due to increasing exposure to industrial pollutants. A disposable screen print carbon electrode was modified with a conductive polymer (PANI) and Zn and/or Cu oxides NPs, obtained through bioreduction in citrus peel extracts (lemon and orange), for ultra-sensitive detection of PB2+, in the Crocodile River water sample. The synthesized materials were characterized with Fourier-transform infra-red spectroscopy (FTIR), ultra-violet visible spectroscopy (UV-Vis), and scanning electron microscopy (SEM). The SPC-modified electrodes designated as SPCE/LPE/BiONPs/PANI and SPCE/OPE/BiONPs/PANI were characterized using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) and eventually deployed in the electrochemical detection of PB2+ in water using square wave voltammetry (SWV) technique. The electrochemical responses of the modified electrodes for both CV and EIS in 0.1 M HCl demonstrated enhanced performance relative to the bare SPCE. A detection and quantification limit of 0.494 ppb and 1.647 were obtained at SPCE/LPE/BiONPs/PANI, respectively, while a detection and quantification limit of 2.79 ppb and 8.91 ppb, respectively, were derived from SPCE/OPE/BiONPs/PANI. The relative standard deviations (RSD) for SPC electrode at a 6.04 µM PB2+ analyte concentration was 4.76% and 0.98% at SPCE/LPE/BiONPs/PANI and SPCE/LPE/BiONPs/PANI, respectively. The effect of copper, zinc, iron, cobalt, nickel, and magnesium on the stripping peaks of PB2+ at SPCE/OPE/BiONPs/PANI, showed no significant change except for cobalt, with about 17.67% peak current drop. The sensors were assessed for possible determination of PB2+ in spiked river water samples. The average percentage recovery and RSD calculated were 94.25% and 3.74% (n = 3) at SPCE/LPE/BiONPs/PANI and, 96.70% and 3.71% (n = 3) at SPCE/OPE/BiONPs/PANI, respectively. Therefore, the fabricated sensor material could be used for environmental assessment of this highly toxic heavy metal in the aquatic system

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“…In thermal decomposition process the size of synthesized AuNPs is been determined by reaction temperature, time and surfactant [ 21 ]. However, literatures have reported the chemical approaches of AuNPs synthesis using several reducing agents, but some findings revealed that nanoparticles formed from chemical methods show some threats on human health [ 29 ].…”

Section: Methods Of Synthesizing Aunpsmentioning

confidence: 99%

Bioremediation and pharmacological applications of gold nanoparticles synthesized from plant materials

Akintelu

Yao

Folorunso

2021

Heliyon

Self Cite

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Nanotechnology and nanoscience are gaining remarkable attention in this era due to their distinctive properties and multi applications. Gold nanoparticles (AuNPs) is one of the most relevant metal nanoparticles with enormous applications in various field of research and industries. The demand for AuNPs is increasing rapidly. Extensive awareness has been allotted to the development of novel approaches for the synthesis of AuNPs with quality morphological properties using biological sources due to the limitations associated with the chemical and physical methods. Several factors such as contact time, temperature, pH of solution media, concentration of gold precursors and volume of plant extract influences the synthesis, characterization and applications of AuNPs. Characterization of synthesized AuNPs is important in evaluating the morphological properties of AuNPs since the morphological properties of AuNPs affect their potential use in various applications. This review highlights various methods of synthesizing AuNPs, parameters influencing the biosynthesis of AuNPs from plant extract, several techniques used for AuNPs characterization and their potential in bioremediation and biomedical applications.

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A Review on Green Synthesis of Zinc Oxide Nanoparticles Using Plant Extracts and Its Biomedical Applications

Cited by 147 publications

References 131 publications

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Recent Advances in Zinc Oxide Nanoparticles (ZnO NPs) for Cancer Diagnosis, Target Drug Delivery, and Treatment

Electrochemical Characterization and Detection of Lead in Water Using SPCE Modified with BiONPs/PANI

Bioremediation and pharmacological applications of gold nanoparticles synthesized from plant materials

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