A review on hydroxy anthraquinones from bacteria: crosstalk’s of structures and biological activities

Chandrasekhar, Cheemalamarri; Batchu, Uma Rajeswari; Thallamapuram, Nagendra Prasad; Katragadda, Suresh; Shetty, Prakasham Reddy

doi:10.1080/14786419.2022.2039920

Cited by 14 publications

(8 citation statements)

References 89 publications

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“…The presence of a single electronegative atom (OH) in the OMC will show less charge separation which ultimately improves the DMSO solubility of the compound [44] . On top of that, the reduced toxicity profile of OMC [14] compared to chrysophanol might excel in its utility as a therapeutic agent in future clinical studies.…”

Section: Resultsmentioning

confidence: 99%

“…The copyright holder for this preprint this version posted March 4, 2023. ; https://doi.org/10.1101/2023.03.04.531071 doi: bioRxiv preprint Researchers worldwide evaluated various biologically originated novel compounds as XO inhibitors and noticed that few hydroxyl anthraquinones (HAQ) and their derivatives viz., anthrarobin, anthragallol, aloe-emodin, and chrysophanol have been explored as potent XO inhibitors. Over the above, earlier literature reports explored the potent anti-inflammatory potential of HAQ along with other bio functionalities and observed to be promising with minimal side effects [13][14][15] . Maksimovic et al, 2010 reported that compounds having antioxidant and antiinflammatory potential are also competent to treat gout and associated inflammatory diseases owing to their ability to reduce uric acid & ROS levels [16] .…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Xanthine oxidase by 1-O-methyl chrysophanol, a hydroxyanthraquinone isolated fromAmycolatopsis thermoflavaICTA 103

Batchu¹,

Reddi

Surapaneni³

et al. 2023

Preprint

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Hyperuricemia caused by elevated levels of serum uric acid is responsible for implication of gout and other associated disorders that influence the human health. So far, Xanthine oxidase (XO) inhibitors are the choice of first line drugs for the treatment of hyperuricemia. The objective of the present study was to isolate a potent XO inhibitor from the actinobacteria and to evaluate its inhibitory mechanism. Initially, XO was isolated from bovine milk using standard protocol and enzyme kinetics were evaluated. Thereafter, culture filtrates of actinobacteria (Amycolatopsis thermoflavaICTA 103),Streptomyces luteireticuliICTA 16,Streptomyces kurssanoviiICTA165 andAmycolatopsis luridaICTA 194) were screened for XO inhibition usingin vitroqualitative NBT plate assay followed by extraction and purification of potent inhibitor 1-O-methyl chrysophanol (OMC), from the culture filtrate ofAmycolatopsis thermoflavaICTA 103, which belongs to hydroxy anthraquinones (HAQ) family. Further,in silicomolecular model building was performed to study the binding affinity of OMC towards XO followed by quantitativein vitrospectroscopic assays. The molecular building study explored the mechanistic view of binding interaction between inhibitor & enzyme and the results were corroborates with thein vitrokinetic study. Thein vitroresults revealed the significant enzyme inhibition potential of OMC with an IC50andKivalue of 24.8 ± 0.072 µM & 2.218 ± 0.3068 µM respectively. These results are comparable to standard allopurinol, however, more significant than its structural analog, chrysophanol. The kinetic analysis revealed that OMC is a reversible slow binding inhibitor and the Lineweaver - Burkplot analysis showed mixed type inhibition of OMC against XO. These results are in agreement with chrysophanol. Findings of this study proposed a new derivative of HAQ in the pipeline of hyperuricemia therapeutic drug candidates.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of Xanthine oxidase by 1-O-methyl chrysophanol, a hydroxyanthraquinone isolated fromAmycolatopsis thermoflavaICTA 103

Batchu¹,

Reddi

Surapaneni³

et al. 2023

Preprint

Self Cite

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“…Anthraquinones have been used as relevant antibiotics and antitumor agents. , Functionalization of hydroxy anthraquinones with propargyl bromide generates planar, conjugated ligands to form C(sp)–Au bonds, leading to complexes that are luminescent. A key optical advantage in the context of metal complexes is the added emissive property from the anthraquinone chromophore in the visible region.…”

Section: Gold Complexes For Biomedical Imaging and Sensingmentioning

confidence: 99%

Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

et al. 2023

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The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of inflammatory arthritis including rheumatoid and juvenile arthritis; however, new gold agents have been slow to enter the clinic. Repurposing of auranofin in different disease indications such as cancer, parasitic, and microbial infections in the clinic has provided impetus for the development of new gold complexes for biomedical applications based on unique mechanistic insights differentiated from auranofin. Various chemical methods for the preparation of physiologically stable gold complexes and associated mechanisms have been explored in biomedicine such as therapeutics or chemical probes. In this Review, we discuss the chemistry of next generation gold drugs, which encompasses oxidation states, geometry, ligands, coordination, and organometallic compounds for infectious diseases, cancer, inflammation, and as tools for chemical biology via gold–protein interactions. We will focus on the development of gold agents in biomedicine within the past decade. The Review provides readers with an accessible overview of the utility, development, and mechanism of action of gold-based small molecules to establish context and basis for the thriving resurgence of gold in medicine.

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“…Among the natural quinones, anthraquinones are the largest group, with about 700 reported compounds. Most of these molecules have been isolated from plants, lichens, and fungi, although they are also distributed in microorganisms, insects, and animals [ 91 , 92 ]. However, these organisms use different biosynthetic pathways for the production of anthraquinones.…”

Section: Quinonesmentioning

confidence: 99%

Quinones as Promising Compounds against Respiratory Viruses: A Review

2023

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Respiratory viruses represent a world public health problem, giving rise to annual seasonal epidemics and several pandemics caused by some of these viruses, including the COVID-19 pandemic caused by the novel SARS-CoV-2, which continues to date. Some antiviral drugs have been licensed for the treatment of influenza, but they cause side effects and lead to resistant viral strains. Likewise, aerosolized ribavirin is the only drug approved for the therapy of infections by the respiratory syncytial virus, but it possesses various limitations. On the other hand, no specific drugs are licensed to treat other viral respiratory diseases. In this sense, natural products and their derivatives have appeared as promising alternatives in searching for new compounds with antiviral activity. Besides their chemical properties, quinones have demonstrated interesting biological activities, including activity against respiratory viruses. This review summarizes the activity against respiratory viruses and their molecular targets by the different types of quinones (both natural and synthetic). Thus, the present work offers a general overview of the importance of quinones as an option for the future pharmacological treatment of viral respiratory infections, subject to additional studies that support their effectiveness and safety.

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A review on hydroxy anthraquinones from bacteria: crosstalk’s of structures and biological activities

Cited by 14 publications

References 89 publications

Inhibition of Xanthine oxidase by 1-O-methyl chrysophanol, a hydroxyanthraquinone isolated fromAmycolatopsis thermoflavaICTA 103

Inhibition of Xanthine oxidase by 1-O-methyl chrysophanol, a hydroxyanthraquinone isolated fromAmycolatopsis thermoflavaICTA 103

Next Generation Gold Drugs and Probes: Chemistry and Biomedical Applications

Quinones as Promising Compounds against Respiratory Viruses: A Review

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