A review on Kaff Maryam (Anastatica hierochuntica L.): chemical constituents, pharmacological activities and role on fertility

Abstract

Anastatica hierochuntica L., a plant widely used in folkloric medicine in Arab countries, has gained attention for its therapeutic properties. The plant is employed as an herbal remedy to address various diseases, including gynecological health issues. Its pharmacological effects are attributed to a diverse array of phytoconstituents, including steroids, triterpenoids, flavonoids, tannins, fatty acids, coumarins, alkaloids and more. According to research, A. hierochuntica has a variety of useful properties, including anti-cancer, antioxidant, anti-diabetic, anti-inflammatory, gastroprotective, immunostimulant, hepatoprotective and antibacterial properties. Notably, the plant has been recognized for its role in infertility treatment, with several scientific studies supporting its therapeutic value in this regard. This review aims to provide a comprehensive overview of A. hierochuntica, covering aspects such as plant description, traditional uses, chemical constituents and pharmacological activities. Emphasis is placed on the plant’s potential in infertility treatment and this review work explores possible mechanisms behind this role. The article underscores the multifaceted potential of A. hierochuntica in offering a variety of health benefits and encourages further exploration for its application in the development of novel treatments.