A Review on Medicinal Plant Piper cubeba L. and Its Pharmaceutical Properties

Kumar, Pradeep

doi:10.26855/ijfsa.2021.03.022

Cited by 5 publications

(3 citation statements)

References 37 publications

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“…It isbeing cultivated worldwide and grows in dry warm climates. This plant is grown commercially in United States and Chile, as well as in Arabia, Persia, China, India, and Japan ( Kumar, 2021 ). It has a religious importance in Muslims and Christanity ( Slavin, 2006 ).…”

Section: Resultsmentioning

confidence: 99%

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

Ahmed

Jamil

Ismatullah

et al. 2023

Saudi Journal of Biological Sciences

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Section: Resultsmentioning

confidence: 99%

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

Ahmed

Jamil

Ismatullah

et al. 2023

Saudi Journal of Biological Sciences

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“…Berries, leaves, and stalks are widely exploited in spice market, and also used as food preservative, coloring aid and in cosmetics (9)(10)(11).…”

Section: Compound Name Referencesmentioning

confidence: 99%

Cubeb (Piper cubeba L.f.): A comprehensive review of its botany, phytochemistry, traditional uses, and pharmacological properties

et al. 2022

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Piper cubeba L.f. (Piperaceae), known as cubeb, is a popular traditional herbal medicine used for the treatment of many diseases, especially digestive and respiratory disorders. The plant is rich in essential oil, found mainly in fruits, and this makes it economically important. Many traditional utilizations have been also validated from the plant and its isolated compounds owing to their antioxidant, antibacterial, anti-inflammatory and anticancer effects. These biological activities are attributed to the phytochemicals (phenolic compounds, lignans and alkaloids) and the essential oil of the plant. The present work aims to provide an up-to-date review on the traditional uses, phytochemistry and pharmacology of the plant and discusses the future perspectives to promote its valorization for nutritional- and health-promoting effects.

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“…These include antioxidant, anti-cancer, anti-inflammatory, anti-diabetic, antiparasitic, antibacterial activities in addition to its ability to modulate melanogenesis ( 6 – 9 ). Furthermore, a recent study revealed promising hepato- and renoprotective activities by the plant ( 10 – 12 ).…”

Section: Introductionmentioning

confidence: 99%

Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties

Drissi,

Mahdi,

Ortaakarsu

et al. 2024

Front. Nutr.

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IntroductionCubeb, Piper cubeba L., has been used for centuries in traditional medicine and culinary practices, with a wide range of biological and pharmacological activities.ObjectiveHerein, we determined the phytochemical profile, mineral, fatty acids, and amino acid contents of P. cubeba berries and assessed the dermacosmeceutical properties of their water extract and essential oil (EO). These included assessing their antioxidant and antibacterial activities as well as their in vitro inhibitory activities against tyrosinase and elastase enzymes. In addition, molecular docking and molecular dynamics studies were performed on the major identified compounds of the EO.Results and discussionA total of forty-three compounds belonging to organic acids, phenolic acids and flavonoids were found in the water extract, while 36 volatile compounds were identified in the EO with Z-isoeugenol, dihydroeugenol, β-pinene, E-caryophyllene, and 1,8-cineole as major constituents. The berries were found to be rich in sodium and iron, have moderate zinc content along with low contents of total nitrogen, phosphorus, and potassium. Amino acid analysis revealed a considerable concentration of isoleucine and phenylalanine, whereas 11,14,17-eicosatrienoic acid and linoleic acid were identified as the major fatty acids. In the DPPH and FRAP assays, the water extract elicited considerable antioxidant activity compared to the reference compounds. Enzyme inhibitory assays revealed that the EO had a potential to inhibit tyrosinase and elastase enzymes with IC50 values of 340.56 and 86.04 μg/mL, respectively. The water extract and EO completely inhibited the bacterial growth at MIC of 50 mg/mL and 20%, respectively. At sub-MIC concentrations, the extract and the EO substantially reduced the biofilm formation by up to 26.63 and 77.77%, respectively, as well as the swimming and swarming motilities in a dose-dependent manner. Molecular docking and molecular dynamics showed that the five main components of P. cubeba EO could be the major contributors to the elastase and tyrosinase inhibitory effect.ConclusionThis study emphasizes the promising potential of P. cubeba as a valuable source of natural compounds that can be utilized for the development of innovative pharmaceuticals, dietary supplements, and dermacosmeceutical agents.

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A Review on Medicinal Plant Piper cubeba L. and Its Pharmaceutical Properties

Cited by 5 publications

References 37 publications

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

A comprehensive perspective of traditional Arabic or Islamic medicinal plants as an adjuvant therapy against COVID-19

Cubeb (Piper cubeba L.f.): A comprehensive review of its botany, phytochemistry, traditional uses, and pharmacological properties

Cubeb (Piper cubeba L.): nutritional value, phytochemical profiling and dermacosmeceutical properties

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